A5017263139- Phytochemistry and biological activity of medicinal plants
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Fungal Biology and Applications
- Ginseng Biological Effects and Applications
- Identification and Quantification in Food
- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Phytochemistry and Biological Activities
- Bioactive Compounds and Antitumor Agents
- Food Quality and Safety Studies
- Analytical Chemistry and Chromatography
- Plant-based Medicinal Research
- Mass Spectrometry Techniques and Applications
- Plant-derived Lignans Synthesis and Bioactivity
- Meat and Animal Product Quality
- Advanced Proteomics Techniques and Applications
- Biological and pharmacological studies of plants
- Phytochemicals and Antioxidant Activities
- Plant and fungal interactions
- Traditional Chinese Medicine Studies
- Protein Hydrolysis and Bioactive Peptides
- Drug-Induced Hepatotoxicity and Protection
- Plant biochemistry and biosynthesis
National Institutes for Food and Drug Control
2016-2025
China Southern Power Grid (China)
2023-2024
Civil Aviation University of China
2024
Shenzhen Institute of Information Technology
2023
Harbin Institute of Technology
2023
National Medical Products Administration
2005-2022
United States Food and Drug Administration
2011-2015
Beijing University of Chinese Medicine
2011-2015
Environmental Molecular Sciences Laboratory
1996
Pacific Northwest National Laboratory
1996
Abstract Alternative medicines are commonly used for the disease prevention and treatment worldwide. Aristolochic acid (AAI) nephropathy (AAN) is a common rapidly progressive interstitial caused by ingestion of Aristolochia herbal medications. Available data on pathophysiology molecular mechanisms AAN limited were explored here. SD rats randomized to control groups. group was treated with AAI oral gavage 12 weeks observed additional weeks. Kidneys processed histological evaluation, Western...
Abstract Chronic kidney disease (CKD) is a major public health problem worldwide. Rhubarb has been shown to have nephroprotective and anti-fibrotic activities in patients with CKD. However, bioactive fractions biochemical mechanism of properties rhubarb remain unclear. Here we applied ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry together univariate multivariate statistical analyses investigate the urinary metabolite profile rats adenine-induced CKD...
Chronic kidney disease (CKD) is becoming a worldwide public health problem. In this study, metabonomics method based on the ultra performance liquid chromatography/high-sensitivity mass spectrometry with MS(E) data collection technique was undertaken to explore excretion pattern of low molecular metabolites in rat model adenine-induced chronic renal failure (CRF). Coupled blood biochemistry and histopathology results, significant difference metabolic profiling between CRF group control by...
Chronic renal failure (CRF) is a major public health problem worldwide. Earlier studies have revealed salutary effects of rhubarb extracts in CRF. In this study, we employed lipidomic and metabolomic approaches to identify the plasma biomarkers determine effect treatment with petroleum ether, ethyl acetate n-butanol rat model CRF adenine-induced chronic tubulointerstitial nephropathy. addition, clinical biochemistry, histological evaluation pro-fibrotic protein expression were analyzed....
An ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC Q-TOF MS) metabonomics approach was employed to study the serum metabolic profiling of adenine-induced chronic renal failure (CRF) rats. Acquired data were subjected principal component analysis (PCA) for differentiating CRF and normal control groups. Potential biomarkers screened by using S-plot identified accurate mass, isotopic pattern MS/MS fragments information obtained from UPLC MS...
Chronic renal failure (CRF) is a major challenge for the public healthcare problem. A novel UPLC Q-TOF/MS method with MSE data collection mode was developed as very effective biochemical analytical tool precise identification of important biomarkers in adenine-induced CRF rats. Nine endogenous metabolites were identified by using metabonomic combined multivariate analysis, accurate mass, isotopic pattern, fragments information and MassLynx i-FIT algorithm. The indicated perturbations bile...
Mountain-cultivated ginseng (MCG) and cultivated (CG) both belong to Panax have similar ingredients. However, their pharmacological activities are different due significantly growth environments. An ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS)-based approach was developed distinguish MCG CG. Multivariate statistical methods, such as principal component analysis supervised orthogonal partial-least-squares discrimination were used select...
The binding stoichiometry of gene V protein from bacteriophage f1 to several oligonucleotides was studied using electrospray ionization-mass spectrometry (ESI-MS). Using mild mass spectrometer interface conditions that preserve noncovalent associations in solution, observed as dimer ions a 10 mM NH4OAc solution. Addition resulted formation protein-oligonucleotide complexes with approximately four nucleotides (nt) per monomer. A 16-mer oligonucleotide gave predominantly 4:1 (protein monomer:...
Two new unusual natural pigments were first isolated from the whole herbs of Selaginella tamariscina. The structure selaginellin A (1) was established as (R,S)-4-[(4'-hydroxy-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene]-2,5-cyclohexadien-1-one and B (2) (R,S)-4-[(4'-methoxy-4-(methyl)-3-((4-methoxyphenyl)ethynyl)biphenyl-2-yl)(4-methoxyphenyl)methylene]-2,5-cyclohexadien-1-one, along with four known biflavonoids, amentoflavone (3), hinokiflavone (4), heveaflavone...