A5100376029- Metabolomics and Mass Spectrometry Studies
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Pediatric health and respiratory diseases
- Computational Drug Discovery Methods
- Traditional Chinese Medicine Analysis
- Chemical Synthesis and Analysis
- Cancer, Lipids, and Metabolism
- Tryptophan and brain disorders
- Liver Disease Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Enzyme Structure and Function
- Ferroptosis and cancer prognosis
- Medicinal Plants and Bioactive Compounds
- Glycosylation and Glycoproteins Research
- Cytokine Signaling Pathways and Interactions
- Asthma and respiratory diseases
- Nutrition, Genetics, and Disease
- Drug-Induced Hepatotoxicity and Protection
- Plant biochemistry and biosynthesis
- Diet, Metabolism, and Disease
- Fatty Acid Research and Health
Guangzhou University of Chinese Medicine
2011-2025
Third Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2025
Guangdong Institute for Drug Control
2023-2024
University of Hong Kong - Shenzhen Hospital
2024
University of Hong Kong
2024
Jinzhou Medical University
2023
Xiamen University
2022
Merck & Co., Inc., Rahway, NJ, USA (United States)
2022
Chaohu University
2021
The pathogenesis of depression remains largely unknown. Accumulating evidence demonstrates the existence a complex relationship between gut microbiome composition and brain functions. Jia Wei Xiao Yao San (JWXYS) is considered potential antidepressant. However, pharmacological mechanisms JWXYS have not yet been clarified. This study aimed to explore effects on chronic stress-induced depression-like behaviors in mice. A restraint stress mouse model was established. administered, responses...
Mountain-cultivated ginseng (MCG) and cultivated (CG) both belong to Panax have similar ingredients. However, their pharmacological activities are different due significantly growth environments. An ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS)-based approach was developed distinguish MCG CG. Multivariate statistical methods, such as principal component analysis supervised orthogonal partial-least-squares discrimination were used select...
Hyperlipidemia refers to a chronic disease caused by systemic metabolic disorder, and its pathophysiology is very complex. Shanmei capsule (SM) famous preparation with long tradition of use for anti-hyperlipidemia treatment in China. However, the regulation mechanism SM on hyperlipidemia has not been elucidated so far. In this study, combination UPLC-Q-TOF/MS techniques 16S rDNA gene sequencing was performed investigate effects plasma metabolism-mediated change intestinal homeostasis. The...
Xanthoceras sorbifolia Bunge oil (XSBO) has garnered significant interest from researchers due to its distinctive anti-Alzheimer's disease (AD) properties. However, the underlying molecular mechanism remain unclear. This study aims investigate potential mechanisms by which XSBO may exert therapeutic effects on AD employing a combination of network pharmacology analysis and experimental validation. The chemical composition absorbed compounds were identified using GC-MS LC-MS. Network was...
The recently discovered antibiotic burnettramic acid A (1) and three new congeners, acids C–E (2–4), were identified from the co-cultures of two marine Aspergillus strains. structure was revised on basis reinterpretation nuclear magnetic resonance (NMR) data chemical derivatization. full absolute configurations established using Mosher ester method Marfey's analysis, combined with density functional theory calculation NMR electric circular dichroism data.
Zhenwu decoction (ZWD) is a promising traditional Chinese prescription against renal fibrosis, while its underlying mechanism remains unclear. Rat model of fibrosis were established and divided into control group, ZWD treatment group enalapril maleate group. Metabolic profiles on serum samples from each acquired by using ultra performance liquid chromatography coupled with quadrupole time-of-flight high-resolution mass spectrometry. Metabolomics combined molecular biology comparatively...
BACKGROUND: Shanmei Capsule is a famous preparation in China. However, the related mechanism of against hyperlipidemia has yet to be revealed. OBJECTIVE: To elucidate underlying through network pharmacology approach and molecular docking. METHODS: Active ingredients, targets as well for were screened based on database. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment performed via Database Annotation, Visualization, Integrated Discovery (DAVID) 6.8...
The functional study and application of an intact glycoprotein require the structural characterization both protein backbone glycan moiety; former has been successfully demonstrated with selective fragmentation in CID ExD; whether latter can be achieved moiety remains to explored.RNase B solution was electrosprayed its glycoforms GlcNAc2 Mann (n = 5-9) highest abundance (charge state z 16) were isolated individually fragmented using CID, ETD, HCD, ETciD, EThcD on Orbitrap Fusion Lumos...
An integrated workflow is described that combines micromole-scale high-throughput experimentation (HTE) reaction screening and solid-phase peptide synthesis (SPPS) to enable rapid synthetic method development for on-resin diversification. Using this new approach, we have identified several sets of robust Suzuki–Miyaura coupling conditions with complementary scope collectively display broad coverage respect both resin-bound substrates containing aryl halide side chains (hetero)arylboronic...
BACKGROUND: Ginkgo Folium has a favorable effect on non-alcoholic fatty live disease (NAFLD), but its mechanism remains unclear. OBJECTIVE: The aim of this study is to reveal the underlying in treatment NAFLD. METHODS: Ingredients and ingredients-related genes were collected from TCMSP database SwissTargetPrediction website, respectively. Genecards was used obtain NAFLD-related genes. Next, protein-protein interaction network key ingredients-genes constructed via Cytoscape3.7.0. Based...
Panax ginseng, known as the "king of herbs", is a highly valued medicinal plant, and its parts include roots, stems, leaves, flowers, fruits, among which roots are most commonly used. The main active components this plant triterpenoid saponins, polysaccharides, peptides, volatile oils. chemical metabolites endow herb with variety pharmacological effects, thus used to treat various diseases play healthcare roles. Currently, wide range preparations P. ginseng have been officially...
Cetuximab, used to treat head and neck squamous cell carcinoma metastatic colorectal cancer, can cause severe infusion reactions.
The present study was designed to simultaneously isolate the less polar ginsenosides from flower buds of Panax ginseng (FBPG). Five ginsenosides, including a pair new 20-methoxyl isomers, were extracted FBPG and purified through five-step integrated strategy, by combining ultrasonic extraction, Diaion Hp-20 macroporous resin column enrichment, solid phase extraction (SPE), reversed-phase high-performance liquid chromatography (RP-HPLC) analysis preparation, nuclear magnetic resonance (NMR)...
Blood stasis syndrome (BSS) is one of the most common symptoms cardiovascular diseases (CVDs) in traditional Chinese medicine (TCM) theory. Previous studies have identified that Salvia miltiorrhiza (Danshen) has beneficial effects on BSS, but there no relevant research from perspective lipidomics to study mechanism Danshen against BSS since hyperlipidemia been widely accepted risk factor CVDs. In this study, technology combined with network pharmacology was applied investigate pathological...
In this paper, one-step hydrothermal and electrodeposition methods were used to prepare a MoS2 quantum dot (QD) solid-phase electrochemiluminescent (ECL) electrode for the detection of melamine residues in milk powder. With assistance chitosan, QDs fixed by method show better ECL performance than those traditional deposition due dispersibility stability. Based on quenching signal melamine, quantitative sample was performed. The structure morphology MoS2-CHIT/indium tin oxide (ITO)...
Abstract Background In our previous study it was found that CENPL overexpressed in hepatocellular carcinoma and significantly predicted patient's prognosis. However, the expression prognostic value of other gastrointestinal tumors remain unknown. Therefore, we investigated esophageal (ESCA), stomach adenocarcinoma (STAD), pancreatic (PAAD), colon (COAD) rectum (READ). Methods this study, Oncomine, GEPIA, OncoLnc, TIMER, cBioPortal, miRWalk ENCORI databases were used to analyze level mRNA,...
Conventional disease animal models have limitations on the conformity to actual clinical situation. Disease-syndrome combination (DS) modeling may provide a more efficient strategy for biomedicine research. Disease model and DS of renal fibrosis in chronic kidney were established by ligating left ureter unilateral ureteral combined with exhaustive swimming, respectively. Serum metabolomics was conducted evaluate using ultra performance liquid chromatography coupled quadrupole time-of-flight...
Gastric cardia adenocarcinoma (GCA) has a high mortality rate worldwide; however, current early diagnostic methods lack efficacy. Therefore, the aim of present study was to identify potential biomarkers for diagnosis GCA. Global metabolic profiles were obtained from plasma samples collected 21 patients with GCA and 48 healthy controls using ultra‑performance liquid chromatography/quadrupole‑time‑of‑flight mass spectrometry. The orthogonal partial least squares discrimination analysis model...
Many studies demonstrated that Zhenwu decoction (ZWD) is effective in the treatment of kidney fibrosis, whereas mechanism remains unclear. In this work, a microbiomics-based strategy was used to investigate protective effects ZWD on fibrosis. Unilateral ureteral obstruction replicate rat model renal and rats were divided into prophylactic, early, progression stages according timing administration. Feces collected perform microbiota evaluation by high-throughput 16S DNA sequencing. The...