A5101923367- Immune Cell Function and Interaction
- Organ Transplantation Techniques and Outcomes
- Drug Transport and Resistance Mechanisms
- Natural product bioactivities and synthesis
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- Synthesis and Characterization of Heterocyclic Compounds
- Cytomegalovirus and herpesvirus research
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Photodynamic Therapy Research Studies
- Liver Disease and Transplantation
- Nanocomposite Films for Food Packaging
- Gastroesophageal reflux and treatments
- Hepatitis B Virus Studies
- Plant Toxicity and Pharmacological Properties
- Cancer Cells and Metastasis
- Advancements in Transdermal Drug Delivery
- RNA modifications and cancer
- Chromatography in Natural Products
- Berberine and alkaloids research
- Thyroid and Parathyroid Surgery
- Biological Activity of Diterpenoids and Biflavonoids
Zhejiang Chinese Medical University
2018-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2015-2024
Sun Yat-sen University
2010-2024
National Institutes for Food and Drug Control
2008-2024
First Affiliated Hospital of Bengbu Medical College
2024
National Medical Products Administration
2022
Beijing Friendship Hospital
2020
Capital Medical University
1995-2020
Beijing Children’s Hospital
2020
Pharmaceutical Biotechnology (Czechia)
2020
Exploring the mechanism through which berberine (Ber) reverses multidrug resistance (MDR) of breast cancer is great importance. Herein, we used methyl thiazolyl tetrazolium assay to determine drug and cytotoxicity Ber doxorubicin (DOX) alone or in combination on cell line MCF-7/DOXFluc. The results showed that could synergistically enhance inhibitory effect DOX tumor proliferation vitro, optimal ratio was Ber/DOX = 2:1. Using a luciferase reporter system combined with bioluminescence imaging...
Two new unusual natural pigments were first isolated from the whole herbs of Selaginella tamariscina. The structure selaginellin A (1) was established as (R,S)-4-[(4'-hydroxy-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene]-2,5-cyclohexadien-1-one and B (2) (R,S)-4-[(4'-methoxy-4-(methyl)-3-((4-methoxyphenyl)ethynyl)biphenyl-2-yl)(4-methoxyphenyl)methylene]-2,5-cyclohexadien-1-one, along with four known biflavonoids, amentoflavone (3), hinokiflavone (4), heveaflavone...
MicroRNA-messenger RNA (miRNA-mRNA) regulatory networks are essential factors that regulate tumor development and metastasis in various cancers including gallbladder carcinoma (GBC). Here, we identified the miR-195-5p/Fos-like antigen-1 (FOSL1) axis GBC by bioinformatics analysis aimed to investigate its role mechanism progression of GBC.Bioinformatics was used construct a miRNA-mRNA network. Real-time quantitative polymerase chain reaction (qRT-PCR), western blot, dual luciferase reporter...
AMAP1 was a GTPase‐activating protein that regulates cytoskeletal structures in focal adhesions, circular dorsal ruffles, and promote cell differentiation tumor cells. But the activation function of breast cancer remain largely unexplored. Here we show phosphorylated translocated to plasma membrane formed stable complex with Pyk2 response CCL18. Moreover, CCL18‐dependent translocation interfered AMAP1‐IKK‐β interaction, resulting nuclear factor‐kappaB (NF‐κB) activation. Depletion expression...
Colorectal cancer (CRC) is the third and second most common type of diagnosed in males females, respectively, fourth leading cause cancer-associated mortality worldwide. Liver metastasis primary patients with CRC, therefore requires therapeutic focus. Regulatory T cells (Tregs) hepatic stellate (HSCs) are potentially involved regulating immune response during liver metastasis. The aim present study was to evaluate influence CD4+ forkhead box p3 (Foxp3)+ Tregs HGF/c-Met signaling pathway CRC....
The mitochondrial GTPase mitofusin-2 (MFN2) gene can suppress the cell cycle and regulate proliferation in a number of types. However, its function hepatic fibrosis remains largely unexplored. We attempted to understand mechanism MFN2 stellate (HSC) development fibrosis. Rat HSC-T6 HSC were cultured transfected by adenovirus- (Ad-) Mfn2 or negative control (NC) vector (Ad-green fluorescent protein (GFP)); rat liver cirrhosis model was established via subcutaneous injection with carbon...
Metabolomics is an essential discipline in industrial biotechnology. Sample preparation approaches dramatically influence data quality and, ultimately, interpretation and conclusions from metabolomic experiments. However, standardized protocols for highly reproducible metabolic datasets are limited, especially the fungal cell factory Aspergillus niger. Here, improved liquid chromatography-tandem mass spectrometry-based pipeline A. niger metabolomics developed. It found that fast filtration...
To establish a dynamic nomogram based on preoperative clinical data for prediction of lateral lymph node metastasis (LLNM) papillary thyroid carcinoma.Retrospective study.The Sixth Affiliated Hospital Sun Yat-Sen University.The 477 patients from 2 centers formed the training group and validation were retrospectively reviewed. Preoperative factors influencing LLNM identified by univariable multivariable analysis to construct predictive LLNM. Receiver operating characteristic calibration...
BackgroundLncRNA HOXB-AS3 are associated with tumor progression in several types of carcinomas, yet, its possibly biological role gallbladder carcinoma(GBC) remains unclear. Therefore, this study aimed to investigate the function GBC.MethodsTo know potential carcinoma, real-time polymerase chain reaction was used detected expression carcinoma cells. The colony formation assay and cell counting kit-8 performed measured viability. Flow cytometry analyse apoptosis cycle. Cell invasion migration...
The neutrophil-to-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) level are inflammatory markers related to tumor growth metabolism. This study investigated the value of preoperative NLR, LDH combination NLR (NLR-LDH) for predicting colorectal cancer liver metastasis (CRLM) prognosis in early stages (CRC).Three hundred patients undergoing CRC resection were included. Logistic regression analysis was used estimate correlation between CRLM time markers, Kaplan-Meier survival Cox...
The mechanism of Renshen Shouwu Decoction (RSSW) in treating Alzheimer's disease (AD) remains unknown.
The activation of endoplasmic reticulum (ER) stress is an early pathological hallmark Alzheimer's disease (AD) brain, but how ER contributes to the onset and development AD remains poorly characterized. Mesencephalic astrocyte-derived neurotrophic factor (MANF) a non-canonical inducible protein. Previous studies reported that MANF increased in brains both pre-symptomatic symptomatic patients, consequence rise protein unknown.
Inflammatory myofibroblastic tumor (IMT), previously named inflammatory pseudotumor, is a benign lesion, the exact etiology of which remains obscure; immunosuppression and infections have been speculated to be responsible for development pseudotumor. IMT associated with transplantation rarely reported; we report first case liver in renal patient, who presented symptoms abdominal pain. The findings computed tomography suggested hepatocellular carcinoma or abscess, surgical resection was...
Backgrounds Embolic stroke is one of the main mechanisms ischaemic stroke. Even if treated with recommended antithrombotic agents, recurrence remains high. The Shuxuetong injection, a purified extract traditional Chinese medicine widely used for thrombus diseases in clinical practice China, could be promising agent to prevent recurrence. Aims To describe design injection prevention acute embolism mechanisms. Design Prevention Acute Cerebrovascular events Embolism (SPACE) trial multicentre,...
To investigate how to reduce the incidence of biliary complications in rat orthotopic liver transplantation.A total 165 male Wistar rats were randomly divided into three groups: Group A, orthotropic transplantation with modified "two-cuff" technique; B, bile duct was cut and reconstructed without transplantation; C, only laparotomy performed. Based on approaches used for reconstruction, A two sub-groups:A1 (n = 30), duct-duct A2 duct-duodenum reconstruction. study influence artery...
In this study, a liposomal gel based on pH-gradient method was used to increase the skin-layer retention of monocrotaline (MCT) for topical administration.Using Box-Behnken design, different formulations were designed form liposome suspensions with optimal encapsulation efficiency (EE%) and stability factor (KE). order keep MCT in liposomes accumulate skin slowly selectively, engineered into gels.A prepare suspensions. The formulation (encapsulation efficiency: 83.10 ± 0.21%) as follows: 12...
Ready-made Chinese herbal medicine (RMCHM) is one of the most common types synergistic used worldwide. It based on composite formulae (CHF), which makes quality control this kind traditional (TCM) difficult, let alone distinguishing good from bad. Taking Niuhuang Qingwei Pills (NHQWP) as an example, study reported development a novel principle analysis multiple components in RMCHM. Experimental procedures involved selection high-quality materia medica (CMM, individual medicinal plant parts...
Pyrrolizidine alkaloids (PAs) are secondary metabolites produced by plants. At present, more than 660 PAs have been identified in 6000 plants, mainly belonging to the families Boraginaceae, Compositae, Leguminosae, and so forth. their corresponding nitrogen oxides variedtoxicities, including hepatotoxicity, pulmonary toxicity, genotoxicity. The long-term intake of can lead cancer. This study aimed review literature on tea derived from C. sinensis only. Tea is one most frequently items usedas...