A5055007746- Drug Transport and Resistance Mechanisms
- Berberine and alkaloids research
- Nanoparticle-Based Drug Delivery
- Magnolia and Illicium research
- Cancer therapeutics and mechanisms
- Spectroscopy and Chemometric Analyses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Pharmacological Effects and Toxicity Studies
- Computational Drug Discovery Methods
Zhejiang Chinese Medical University
2020-2022
Exploring the mechanism through which berberine (Ber) reverses multidrug resistance (MDR) of breast cancer is great importance. Herein, we used methyl thiazolyl tetrazolium assay to determine drug and cytotoxicity Ber doxorubicin (DOX) alone or in combination on cell line MCF-7/DOXFluc. The results showed that could synergistically enhance inhibitory effect DOX tumor proliferation vitro, optimal ratio was Ber/DOX = 2:1. Using a luciferase reporter system combined with bioluminescence imaging...
To improve the solubility of Honokiol (HNK), nanoparticles (HNK-NPs) were prepared using a new biodegradable polysaccharide polymer as its carrier.HNK-NPs by hydrophilic coagulation method, and processing parameters optimized according to average particle size PDI single factor experiment. The morphology was investigated TEM, in vitro release carried out evaluate HNK-NPs.The encapsulation efficiency drug loading HNK-NPs 77.75 ± 2.63% 13.46 0.39%, respectively. obtained spherical-like under...