A5012452462- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Pregnancy and preeclampsia studies
- Reproductive Physiology in Livestock
- MicroRNA in disease regulation
- Estrogen and related hormone effects
- Uterine Myomas and Treatments
- Pregnancy and Medication Impact
- Endometrial and Cervical Cancer Treatments
- COVID-19 Impact on Reproduction
- Circular RNAs in diseases
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Ovarian cancer diagnosis and treatment
- Organ and Tissue Transplantation Research
- RNA Research and Splicing
- Prenatal Substance Exposure Effects
- Cancer Mechanisms and Therapy
- Adrenal Hormones and Disorders
- Effects and risks of endocrine disrupting chemicals
- Chromatin Remodeling and Cancer
- Viral Infections and Immunology Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Connective tissue disorders research
- Urological Disorders and Treatments
South China Agricultural University
2017-2024
Key Laboratory of Guangdong Province
2020
Grand Rapids Community College
2016-2019
Michigan State University
2016-2019
Xiamen University
2008-2012
Northeast Agricultural University
2007-2012
Shantou University
2011-2012
MicroRNAs (miRNAs) are 21-24-nucleotide non-coding RNAs found in diverse organisms. Although hundreds of miRNAs have been cloned or predicted, only very few functionally characterized. Embryo implantation is a crucial step mammalian reproduction. Many genes shown to be significantly changed mouse uterus during embryo implantation. However, miRNA expression profiles the between sites and inter-implantation still unknown. In this study, microarray was used examine differential sites. Compared...
ARID1A and PI3-Kinase (PI3K) pathway alterations are common in neoplasms originating from the uterine endometrium. Here we show that monoallelic loss of mouse endometrial epithelium is sufficient for vaginal bleeding when combined with PI3K activation. Sorted mutant epithelial cells display gene expression promoter chromatin signatures associated epithelial-to-mesenchymal transition (EMT). We further bound to promoters open chromatin, but leads increased accessibility EMT genes. activation...
Does a single intrauterine infusion of human chorionic gonadotropin (hCG) at the time corresponding to Day 3 embryo transfer in oocyte donors induce favorable molecular changes endometrium for implantation? Intrauterine hCG was associated with endometrial synchronization between glands and stroma following ovarian stimulation induction early decidual markers stromal cell survival. The clinical potential increasing IVF success rates using an prior remains unclear based on previously reported...
Polyamines are key regulators in cell growth and differentiation. It has been shown that ornithine decarboxylase (Odc) was essential for post-implantation embryo development, overexpression of spermidine/spermine N1-acetyltransferase will lead to ovarian hypofunction hypoplastic uteri. However, the expression function polyamine-related genes mouse uterus during early pregnancy still unknown. In this study we investigated expression, regulation, peri-implantation period. Odc strongly detected...
Abstract Context NOTCH signaling is activated in endometriotic lesions, but the exact mechanisms remains unclear. IL-6, which increased peritoneal fluid of women with endometriosis, induces NOTCH1 through E-proteins including E2A and HEB cancer. Objective To study role inducing expression under regulation IL-6 endometriosis. Setting Design The was first investigated endometrium endometriosis baboon model Regulation examined after stimulation siRNA mediated inhibition or/and human epithelial...
Malayan pangolin SARS-CoV-2-related coronavirus (SARSr-CoV-2) is closely related to SARS-CoV-2. However, little known about its pathogenicity in pangolins. Using CT scans we show that SARSr-CoV-2 positive pangolins are characterized by bilateral ground-glass opacities lungs a similar manner COVID-19 patients. Histological examination and blood gas tests indicative of dyspnea. infected multiple organs pangolins, with the major target, histological expression data revealed ACE2 TMPRSS2 were...
Endometriosis is a chronic, inflammatory, estrogen-dependent gynecological disease characterized by the growth of endometrial stromal cells and glands outside uterine cavity in response to hormones, which commonly occurs reproductive-age women. Zearalenone (ZEA) toxic metabolite produced Fusarium, acts as estrogen activity because similarity its structure estrogen. In this study, we used an endometriosis mouse model: 15 days after ovariectomy, fragments were sutured on pelvic wall, exogenous...
Endometriosis is an estrogen-dependent chronic inflammatory gynecological disease defined by the presence of endometrial glands and mesenchyme outside uterine cavity, named ectopic endometrium. Recent studies showed that endometriosis associated with hormone imbalance, inflammation oxidative stress. As main component vanilla bean extract, vanillin widely used as a flavoring agent in food, pharmaceutical, cosmetic industries. It known for its anti-inflammatory, antibacterial, antitumor...
Embryo implantation is an intricate interaction between receptive uterus and active blastocyst. The mechanism underlying embryo still unknown. Although histamine putrescine are important for decidualization, excess amount of harmful. Amiloride binding protein 1 (Abp1) a membrane-associated amine oxidase mainly metabolizes putrescine. In this study, we first showed that Abp1 strongly expressed in the decidua on d 5–8 pregnancy. expression not detected during pseudopregnancy under delayed but...
Background Delayed implantation is a developmental arrest at the blastocyst stage and good model for embryo implantation. MicroRNAs (miRNAs) have been shown to be involved in mouse through regulating uterine gene expression. This study was an integrative analysis on global miRNA mRNA expression uterus under delayed activation Illumina sequencing. Methodology/Principal Findings By deep sequencing analysis, we found that there are 20 miRNAs up-regulated 42 down-regulated least 1.2 folds, 268...
The establishment of endometrial receptivity is a prerequisite for successful pregnancy, which controlled by complex mechanism. MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as important regulators gene expression. However, the contribution miRNAs in still unknown. Here we used rhesus monkey an animal model and compared miRNA expression profiles during early-secretory (pre-receptive) phase mid-secretory (receptive) deep sequencing. A set differentially expressed were...
Unexplained recurrent pregnancy loss (uRPL) is associated with repeated embryo and endometrial repair elevated expression of inflammatory cytokines, including IFN-γ. Notch signaling through its transcription factor recombination signal binding protein Jκ (RBPJ) regulates mechanisms the immune response after tissue injury. Initially, null mutation RBPJ in mouse uterus ( Pgrcre/+Rbpjf/f; Rbpj c-KO) results subfertility, but we have found that these mice become infertile as a result...
The blastocyst-induced release of ATP by uterine epithelial cells stimulates decidualization and implantation in mice.
High level of uric acid (UA) is the major origin gout, and highly associated with various pregnant complications, such as preeclampsia gestational diabetes. However, UA’s role in very early stage pregnancy has not been uncovered. This study aims to investigate relevance serum UA decidualization, an essential process for establishment maintenance women mice during pregnancy. In this study, we first proved that expression synthase xanthine dehydrogenase (XDH) increased along decidualization...
Fibrosis is a pathological process characterized by abnormal activation of fibroblasts with increased synthesis extracellular matrix components, including collagens. It may lead to loss proper tissue architecture and organ function in clinical diseases such as systemic sclerosis liver fibrosis. Excess accumulation collagens considered the primary indicator Notch signaling has been reported be involved fibrosis many different organs, liver. Our previous study showed that uterine-specific...
Autoimmune Regulator (AIRE) regulates central immune tolerance by inducing expression of tissue-restricted antigens in thymic medullary epithelial cells, thereby ensuring elimination autoreactive T cells. Aire mutations humans and targeted deletion mice result multiorgan autoimmune disease, known as polyglandular syndrome type 1 (APS-1). APS-1 is characterized the presence adrenal insufficiency, chronic mucosal candidiasis, and/or hypoparathyroidism. Additionally, females often present with...
Background Junctional adhesion molecule 2 (Jam2) is a member of the JAM superfamily. JAMs are localized at intercellular contacts and participated in assembly maintenance junctions, control cell permeability. Because Jam2 highly expressed luminal epithelium on day 4 pregnancy, this study was to determine whether plays role uterine receptivity blastocyst attachment mouse uterus. Methodology/Principal Findings days 3 pregnancy. Progesterone induces expression ovariectomized mice, which blocked...