A5083533801- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Health, Environment, Cognitive Aging
- Child Development and Digital Technology
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Language Development and Disorders
- Bladder and Urothelial Cancer Treatments
- Colorectal Cancer Screening and Detection
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- Genetic Syndromes and Imprinting
- Children's Physical and Motor Development
Erasmus MC Cancer Institute
2022-2024
Erasmus MC
2022-2024
Max Planck Institute for Psycholinguistics
2022-2024
Radboud University Nijmegen
2023
Radboud University Medical Center
2023
University Medical Center Utrecht
2021
Abstract Neurological and psychiatric disorders, including substance use share a range of symptoms, which could be the result shared genetic background. Many loci have been identified for these disorders using genome-wide association studies, but conclusive evidence about cell types wherein are active is lacking. We aimed to uncover implicated brain in neuropsychiatric traits assess consistency results across RNA datasets methods. therefore comprehensively employed type enrichment methods by...
Background The number of words children produce (expressive vocabulary) and understand (receptive changes rapidly during early development, partially due to genetic factors. Here, we performed a meta-genome-wide association study vocabulary acquisition investigated polygenic overlap with literacy, cognition, developmental phenotypes neurodevelopmental conditions, including Attention-Deficit/Hyperactivity Disorder (ADHD). Methods We studied 37,913 parent-reported size measures (English,...
Mastering developmental milestones such as infant motor and personal-social skills (including social routines pretend-play) can initiate a cascade of changes that may affect language learning. Specifically, development represent an important, but little understood “gateway” enabling children to interact with their environment. Here, we investigate how abilities link toddler performance, using genetic perspective. For this, studied measures (6 15 months) predictors development, captured by...
Abstract Neurological and psychiatric disorders, including substance use disorders share a range of symptoms, which could be the result shared genetic background. Many loci have been identified for these using genome-wide association studies, but conclusive evidence about cell types wherein are active is lacking. We aimed to uncover implicated brain in neuropsychiatric traits assess consistency results across RNA datasets methods. therefore comprehensively employed cell-type enrichment...
Abstract Background The number of words children produce (expressive vocabulary) and understand (receptive changes rapidly during early development, partially due to genetic factors, although mechanisms are not well understood. Here, we performed a meta-genome-wide association study within the EAGLE consortium investigated polygenic overlap with later-life traits, including Attention-Deficit/Hyperactivity Disorder (ADHD) cognition. Methods We studied 37,913 parent-reported vocabulary size...