A5062397906- Single-cell and spatial transcriptomics
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
BGI Research
2024
BGI Group (China)
2024
The preexistence of immune cells in the tumor microenvironment substantiates efficacy immunotherapy cancer patients. Although complex intratumoral heterogeneity has been extensively studied single cell resolution, hi-res spatial investigations are limited. In this study, we performed a transcriptome analysis 4 colorectal adenocarcinoma specimens and 2 paired distant normal to identify molecular pattern involved discontinuous inflammatory response pathologically annotated regions. Based on...
Colorectal cancer (CRC) patients with mismatch repair (MMR)-deficient (dMMR) but not MMR-proficient (pMMR) tend to benefit from immune checkpoint blockade (ICB) therapy. To profile the tumor microenvironments (TME) underlying these varied therapeutic responses, we integrate spatial enhanced resolution omics-sequencing (Stereo-seq), single-cell RNA sequencing, and multiplexed imaging analysis create high-definition maps of tumors treatment-naïve ICB-treated CRC patients. Our results identify...
<title>Abstract</title> Colorectal cancer (CRC) patients with mismatch repair (MMR)-deficient (dMMR) but not MMR-proficient (pMMR) tend to benefit from immune checkpoint blockade (ICB) therapy. To uncover the rules governing these varied therapeutic responses, we integrated spatial enhanced resolution omics-sequencing (Stereo-seq), single-cell RNA sequencing, and multiplexed imaging analysis create high-definition maps of tumors treatment-naïve ICB-treated CRC patients. Our results...