A5048676521- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- Colorectal Cancer Surgical Treatments
- Lymphoma Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Treatment and Pharmacology
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Phagocytosis and Immune Regulation
- Epigenetics and DNA Methylation
Guangdong Pharmaceutical University
2024-2025
Sun Yat-sen University
2017-2024
Sun Yat-sen University Cancer Center
2017-2024
State Key Laboratory of Oncology in South China
2024
Key Laboratory of Guangdong Province
2024
Background & Aims: Metabolic dysfunction-associated steatohepatitis (MASH) and its related liver fibrosis represent a substantial public health burden with limited treatment options. Although MASH is associated enhanced neutrophil infiltration in the liver, mediators mechanisms underlying neutrophil-driven progression of remain largely unknown. This study aimed to investigate role serine proteases elastase (NE) proteinase 3 (PR3) development fibrosis. Approach: Liver biopsies from 121...
We aimed to compare combined intraoperative chemotherapy and surgical resection with curative alone in colorectal cancer patients.
Colorectal cancer (CRC) patients with mismatch repair (MMR)-deficient (dMMR) but not MMR-proficient (pMMR) tend to benefit from immune checkpoint blockade (ICB) therapy. To profile the tumor microenvironments (TME) underlying these varied therapeutic responses, we integrate spatial enhanced resolution omics-sequencing (Stereo-seq), single-cell RNA sequencing, and multiplexed imaging analysis create high-definition maps of tumors treatment-naïve ICB-treated CRC patients. Our results identify...
Cancer immunotherapy restores or enhances the effector function of T cells in tumor microenvironment, but efficacy has been hindered by therapeutic resistance. Here, we identify proto-oncogene serine/threonine protein kinase PIM2 as a novel negative feedback regulator IFNγ-elicited inflammation, thus endowing cancer with aggressive features. Mechanistically, IL1β derived from IFNγ-polarized macrophages triggered expression via p38 MAPK/Erk and NF-κB signaling pathways. PIM2+ generated...
The role of collagen and its receptor, discoidin domain receptor 1 (DDR1) in immune response colorectal cancer (CRC) remains unclear. We identified DDR1 as a promising target immunotherapy resistance using pooled vivo CRISPR/sgRNA screening microsatellite stable (MSS) CRC mouse models. Our findings demonstrated that knockdown or inhibition could enhance infiltration CD8
Abstract According to the EPOC study, chemotherapy could improve 5-year disease-free survival of stage IV colon cancer patients by 8.1%. However, more molecular biomarkers are required identify who need neoadjuvant chemotherapy. DENND2D expression was evaluated immunohistochemistry in 181 patients. The prognosis better for with than without (5-year overall [OS]: 42% vs. 12%, p = 0.038; survival: 20% 10%, 0.001). Subgroup analysis DENND2D-negative group showed that treated achieved longer OS...
3615 Background: Molecular residual disease (MRD) using circulating tumor DNA (ctDNA) may identify recurrent risk and guide adjuvant chemotherapy (ACT) in colorectal cancer (CRC). This study explored the feasibility of a tumor-informed personalized approach to predict recurrence, comparing with (TI) naïve (TN) fixed panel approaches. Methods: Patients stage I-IV CRC eligible for R0 resection were recruited. Blood samples collected preoperatively, at postoperative day 7 30 (POD7/30), every...
C10orf90, a tumor suppressor, can inhibit the occurrence and development of tumors. Therefore, we investigated gene function C10orf90 in various tumors using multiple pan-cancer datasets. Pan-cancer analysis results reveal that expression levels vary across different hold significant value clinical diagnosis prognosis patients with In some cancers, level is correlated CNV, DNA methylation, immune subtypes, cell infiltration, drug sensitivity particular, COAD, implicated processes associated...
e15002 Background: The safety and efficacy of intraoperative chemotherapy in colorectal cancer have not yet been extensively investigated. This randomized control trial was designed to compare the combination with surgical resection those traditional alone. Patients Methods: From January 2011 2016, 696 patients were enrolled this study: 341 randomly assigned plus surgery group receive (portal vein, intraluminal, intraperitoneal resection), whereas 344 undergo Eleven withdrew consent....
<div>Abstract<p>Cancer immunotherapy restores or enhances the effector function of T cells in tumor microenvironment, but efficacy has been hindered by therapeutic resistance. Here, we identify proto-oncogene serine/threonine protein kinase PIM2 as a novel negative feedback regulator IFNγ-elicited inflammation, thus endowing cancer with aggressive features. Mechanistically, IL1β derived from IFNγ-polarized macrophages triggered expression via p38 MAPK/Erk and NF-κB signaling...