A5107988223- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Mercury impact and mitigation studies
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- Liver Disease Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Atrial Fibrillation Management and Outcomes
- Ginkgo biloba and Cashew Applications
- Drug-Induced Hepatotoxicity and Protection
- Sexual Differentiation and Disorders
- Hormonal Regulation and Hypertension
- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- Traditional Chinese Medicine Analysis
- Heavy Metal Exposure and Toxicity
- Phytochemistry and Biological Activities
- Retinal Development and Disorders
- Pain Mechanisms and Treatments
- Cardiac Fibrosis and Remodeling
- Sirtuins and Resveratrol in Medicine
- Electron Spin Resonance Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Tracheal and airway disorders
Guangzhou University of Chinese Medicine
2011-2025
Guangdong Pharmaceutical University
2025
Shaanxi University of Chinese Medicine
2023
Air Force Medical University
2023
Shanxi Eye Hospital
2023
China Automotive Technology and Research Center
2023
Beijing Luhe Hospital Affiliated to Capital Medical University
2023
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2020-2021
China Medical University
2014-2021
Dezhou University
2007-2020
Recent work has highlighted the potential of puerarin (PU) as a valuable compound to treat Parkinson's disease (PD), but its undesirable water solubility and bioavailability have constrained utility. In this study, we sought develop nanoparticles (NPs) that could be used encapsulate PU, thereby extending in vivo half-life improving accumulation brain symptoms PD. We prepared spherical NPs (88.36 ± 1.67 nm) from six-armed star-shaped poly(lactide-co-glycolide) (6-s-PLGA) were PU (PU-NPs) with...
Salvianolate is the main water-soluble bioactive compound of Salvia Miltiorrhiza Bunge and now clinically used in treatment cardiovascular diseases China. However, its applications prevention atrial interstitial fibrosis (AIF) fibrillation (AF) are not fully revealed. To investigate preventive effect salvianolate on pathogenesis AF post-myocardial infarction (MI) rats to elucidate potential mechanisms. Rats underwent left anterior descending coronary artery ligation were randomized into four...
Resveratrol (RES), a non-flavonoid polyphenol extracted from wide variety of plants, exhibits neuroprotective activities against Parkinson's disease (PD). However, undesirable water solubility RES reduces its oral bioavailability and demonstrates low efficacy in blood brain, thus limiting application. In present study, nanocrystal formulation (RES-NCs) was developed to enhance delivery into brain for PD treatment. RES-NCs were fabricated with hydroxypropyl methylcellulose (HPMC) stabilizer...
Puerarin (PU) has emerged as a promising herb-derived anti-Parkinsonism compound. However, the undesirable water solubility well unwanted bioavailability of PU limit its application. Therefore, this study aimed to develop and characterize nanocrystals (PU-NCs) with enhanced oral improved brain accumulation for treatment Parkinson's disease (PD). The fabricated PU-NCs were approximately spherical, mean size 83.05 ± 1.96 nm, PDI 0.047 0.009, drug loading 72.7%, rapid dissolution rate in vitro....
The purpose of this research was to evaluate whether maltol could protect from hepatic injury induced by carbon tetrachloride (CCl4) in vivo inhibition apoptosis and inflammatory responses. In work, administered at a level 100 mg/kg for 15 days prior exposure single injection CCl4 (0.25%, i.p.). results clearly indicated that the intrapulmonary resulted sharp increase serum aspartate transaminase (AST) alanine (ALT) activities, tumor necrosis factor-α (TNF-α), irreducible nitric oxide...
A new FRET probe has been prepared and successfully used for imaging hydroxyl radicals generated by drug activation endogenous in zebrafish.
Background & Aims: Metabolic dysfunction-associated steatohepatitis (MASH) and its related liver fibrosis represent a substantial public health burden with limited treatment options. Although MASH is associated enhanced neutrophil infiltration in the liver, mediators mechanisms underlying neutrophil-driven progression of remain largely unknown. This study aimed to investigate role serine proteases elastase (NE) proteinase 3 (PR3) development fibrosis. Approach: Liver biopsies from 121...
Chronic kidney disease (CKD) causes atrial structural remodeling and subsequently increases the incidence of fibrillation (AF). Atrial connexins inflammatory responses may be involved in this process. In study, nephrectomy was used to produce CKD rat model. Three months post-nephrectomy, cardiac structure, function AF vulnerability were quantified using echocardiography electrophysiology methods. The left tissue tested for quantification fibrosis inflammation, distribution expression...
Gastric cancer, one of the most common types cancers, develops over a series consecutive histopathological stages. As such, analysis and research gastric precancerous lesions (GPLs) play an important role in preventing occurrence cancer. Ginsenoside Rg3 (Rg3), herbal medicine, plays prevention treatment various cancers. Studies have demonstrated correlation between glycolysis cancer progression. Herein, aim present study was to clarify potential for pathogenesis Rg3-treated GPL Atp4a-/-...
OBJECTIVES: The purpose of this study was to isolate the secondary metabolites endophytic fungi from Ginkgo biloba (SMEFGB) and investigate their anti-cervical cancer activity. METHODS: SMEFGB were cultured. extracted, purified identified. Th e effects on proliferation, apoptosis migration human cervical HeLa cells determined. In addition, growth Hela implanted tumor in mice investigated. RESULTS: 9 stains successfully isolated leaves biloba, stain J-1, J-2 J-3 could produce podophyllotoxin....
The roles of minerals in obesity received increasing attention recently due to its oxidant or antioxidant functions and effects on insulin glucose metabolism that may be associated with obesity. Herein, this study aims explore the association between body mass index (BMI) children different ages, hope provide some references for prevention management high-risk obesity.Data aged 2-17 years old were extracted from National Health Nutrition Examination Survey (NHANES) database 2007-2014...
Parietal cells of the gastric mucosa contain a complex and extensive secretory membrane system that harbors H+, K+-adenosine triphosphatase (ATPase), enzyme primarily responsible for lumen acidification. Here, we describe characterization mice deficient in K+-ATPase α subunit (Atp4a-/-) to determine role this protein biosynthesis biology mucosa. Atp4a-/- were produced by gene targeting. Wild-type (WT) mice, paired age, examined at 10, 12, 14 16 weeks histopathology, expression mucin 2...
Objective: Synaptic plasticity is critical for neurorehabilitation after focal cerebral ischemia. Connexin 43 (Cx43), the main component of gap junction, has been shown to be pivotal synaptic plasticity. The objective this study was investigate role Cx43 inhibitor (Gap26) and junction modifier (GAP-134) in their contribution Methods: Time course expression both total phosphorylated (p-Cx43) were detected by western blotting at 3, 7, 14 d Gap26 GAP-134 administered starting from 3 post...
Ginsenoside Rg3 is a steroidal saponin isolated from Panax ginseng. Previous studies have shown that treatment downregulates the activity of rapamycin complex 1 (mTORC1) and inhibits growth cancer cells. However, inhibitory effect on cells associated with high concentrations are difficult to achieve in vivo. The human cervix adenocarcinoma HeLa were treated Rg3. protein levels AMP-activated kinase alpha (AMPKα), B(Akt), ribosomal S6 protein(S6), Erk determined by immunoblotting analyses. We...
Recent studies have demonstrated that Buyang Huanwu Decoction (BYHWD) decreased glutamate levels subsequent to cerebral ischemia. Glutamate transporter‑1 (GLT‑1) and glutamine synthetase (GS), which are located in astrocytes, mainly contribute transportation, thus reducing concentration. BYHWD has previously been upregulate GLT‑1 GS following ischemia vivo. However, whether can directly influence astrocytic GLT‑1/GS remains unknown. In the present study, effect of containing serum (BYHWD‑CS)...
<b>Rationale:</b> Stimulator of Interferon Genes (STING) is an essential mediator innate immune recognition cytosolic DNA, which plays important roles in cancer, cytotoxic therapies, and infections with certain pathogens. While pharmacological STING activation stimulates potent anti-tumor responses animal models, clinically applicable pharmacodynamic biomarkers that inform on the magnitude, duration, location elicited by systemic agonists are yet to be described. We investigated whether...
The neuroprotective role of Buyang Huanwu decoction (BYHWD) in focal ischemia is associated with decreasing glutamate concentration. However, the mechanisms are not fully understood. present study aimed to explore whether transporter‑1 (GLT‑1) and glutamine synthetase (GS) participated decreased level pituitary adenylate cyclase‑activating polypeptide‑38 (PACAP‑38) was involved this process. BYHWD found significantly upregulate expression GLT‑1 GS hippocampal CA1 area compared group,...