A5067658463- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- RNA Research and Splicing
- Gene expression and cancer classification
- Cancer, Hypoxia, and Metabolism
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Esophageal Cancer Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Esophageal and GI Pathology
- Estrogen and related hormone effects
- Bioinformatics and Genomic Networks
- Immune Response and Inflammation
- Cancer, Lipids, and Metabolism
- Biomedical Text Mining and Ontologies
- Sodium Intake and Health
- Airway Management and Intubation Techniques
- Chromatin Remodeling and Cancer
- Transplantation: Methods and Outcomes
Huazhong University of Science and Technology
2014-2024
Tongji Hospital
2014-2024
Wuhan University
2023-2024
Renmin Hospital of Wuhan University
2023-2024
Harbin Medical University
2016-2023
University of Pittsburgh
2020
Super-enhancers are important for controlling and defining the expression of cell-specific genes. With research on human disease biological processes, H3K27ac ChIP-seq datasets accumulating rapidly, creating urgent need to collect process these data comprehensively efficiently. More importantly, many studies showed that super-enhancer-associated single nucleotide polymorphisms (SNPs) transcription factors (TFs) strongly influence processes. Here, we developed a comprehensive super-enhancer...
Super-enhancers (SEs) are cell-specific DNA cis-regulatory elements that can supervise the transcriptional regulation processes of downstream genes. SEdb 2.0 (http://www.licpathway.net/sedb) aims to provide a comprehensive SE resource and annotate their potential roles in gene transcriptions. Compared with 1.0, we have made following improvements: (i) Newly added mouse SEs expanded scale human SEs. contained 1 167 518 from 1739 H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq)...
Abstract Long non-coding RNAs (lncRNAs) have a critical role in cancer initiation and progression, thus may mediate oncogenic or tumor suppressing effects, as well be new class of therapeutic targets. We performed high-throughput sequencing RNA (RNA-seq) to investigate the expression level lncRNAs protein-coding genes 30 esophageal samples, comprised 15 squamous cell carcinoma (ESCC) samples their paired non-tumor tissues. further developed an integrative bioinformatics method, denoted...
Non-small cell lung cancer (NSCLC) patients with sensitive epidermal growth factor receptor (EGFR) mutations are successfully treated EGFR tyrosine kinase inhibitors (EGFR-TKIs); however, resistance to treatment inevitably occurs. Given lipid metabolic reprogramming is widely known as a hallmark of and intimately linked EGFR-stimulated growth. Activation signal pathway increased monounsaturated fatty acids (MUFA) metabolism key enzyme Stearoyl-CoA Desaturase 1 (SCD1) expression. However the...
Enhancers are a class of cis-regulatory elements that can increase gene transcription by forming loops in intergenic regions, introns and exons. Enhancers, as well their associated target genes, factors (TFs) bind to them, highly with human disease biological processes. Although some enhancer databases have been published, most only focus on enhancers identified high-throughput experimental techniques. Therefore, it is desirable construct comprehensive resource manually curated related...
Septic cardiomyopathy is one of the most severe and common complications in patients with sepsis poses a great threat to their prognosis. However, potential mechanisms effective therapeutic drugs need be explored. The control cardiac cell death by miRNAs has emerged as prominent area scientific interest diagnosis treatment heart disorders recent times. In present investigation, we discovered that overexpression miR-31-5p prevented LPS-induced damage H9C2 cells could inhibit BAP1 production...
In non-small cell lung cancer (NSCLC), estrogen (E2) significantly promotes NSCLC growth via receptor beta (ERβ). Discovery and elucidation of the mechanism underlying estrogen-promoted progression is critical for effective preventive interventions. IL6 has been demonstrated to be involved in development, metastasis several cancers overexpression associated with poor prognosis NSCLC. However, exact role played by progress remain unknown. Here, we evaluated expression biological effects cells...
Accessible chromatin is a highly informative structural feature for identifying regulatory elements, which provides large amount of information about transcriptional activity and gene mechanisms. Human ATAC-seq datasets are accumulating rapidly, prompting an urgent need to comprehensively collect effectively process these data. We developed comprehensive human accessibility database (ATACdb, http://www.licpathway.net/ATACdb), with the aim providing publicly available resources on data,...
A core transcription regulatory circuitry (CRC) is an interconnected self-regulatory that formed by a group of factors (TFs). These TFs collectively regulate gene expression binding not only to their own super enhancers (SEs) but also the SEs one another. For most human tissue/cell types, global view CRCs and has been generated. Here, we identified numerous using two identification methods detailed landscape driven in large cell/tissue samples. The comprehensive biological analyses,...
Abstract With the study of human diseases and biological processes increasing, a large number non-coding variants have been identified facilitated. The rapid accumulation genetic epigenomic information has resulted in an urgent need to collect process data explore regulation variants. Here, we developed comprehensive variation annotation database for (VARAdb, http://www.licpathway.net/VARAdb/), which specifically considers VARAdb provides 577,283,813 variations novel variants, prioritizes...
// Sheng Fan 1 , Yongde Liao Changyu Liu Quanfu Huang Huifang Liang 2 Bo Ai Shegnling Fu and Zhou 3 Department of Thoracic Surgery, Tongji Hospital, Medical College, Huazhong University Science Technology, Wuhan 430030, Hubei Province, China Hepatic Surgery Center, Pathology, Correspondence to: Liao, email: liaotjxw@126.com Keywords: non-small cell lung cancer (NSCLC), estrogen, estrogen receptor beta (ERβ), matrix-metalloproteinase (MMP), metastasis Received: September 14, 2016 Accepted:...
Competing endogenous RNA (ceRNA) have received wide attention because they are a novel way to regulate genes through sharing microRNAs (miRNAs) that crucial for complex processes in many diseases. However, no systematic analysis of ceRNA mechanism cardiovascular disease (CVD) is known. To gain insights into the global properties ceRNAs multi-CVDs, we constructed view mRNA-related cross-talk eight major CVDs from ~2,800 samples. We found common features could be used uncover similarities...
Thoracoscopic mobilization of esophagus and laparoscopic stomach with cervical anastomosis is employed widely in minimally invasive esophagectomy (MIE) for esophageal carcinoma. However, it associated high incidence complications, including recurrent laryngeal nerve injury anastomotic leak. This paper summarizes the key techniques total thoracoscopic intrathoracic MIE 62 patients middle or lower cancer between March 2012 August 2013. Total was performed to treat cancer. Laparoscopic...
Transcription factors (TFs) play key roles in biological processes and are usually used as cell markers. The emerging importance of TFs related markers identifying specific types human diseases increases the need for a comprehensive collection sets. Here, we developed TF-Marker database (TF-Marker, http://bio.liclab.net/TF-Marker/), aiming to provide cell/tissue-specific human. By manually curating thousands published literature, 5905 entries including information about were classified into...
Resumo Fundamento: O antibiótico quimioterápico antraciclina doxorrubicina (DOX) pode induzir cardiotoxicidade cumulativa e levar à disfunção cardíaca. RNAs não codificantes longos (lncRNAs) podem funcionar como importantes reguladores na lesão miocárdica induzida por DOX. Objetivo: Este estudo tem objetivo investigar o papel funcional mecanismo molecular do RNA antisense lncRNA OXCT1 1 (OXCT1-AS1) celular DOX in vitro. Métodos: Cardiomiócitos humanos (AC16) foram estimulados com para um...
Abstract Background Advanced non‐small cell lung cancer (NSCLC) accounts for a high proportion of cases. Targeted therapy improve the survival in these patients, but acquired drug resistance will inevitably occur. If tumor downstaging is achieved after targeted therapy, could surgical resection before clinical benefits patients with advanced NSCLC? Here, we conducted trial showing that driver gene mutant NSCLC who did not progress salvage surgery (SS) progression‐free (PFS). Herein,...
Abstract Cardiac hypertrophy (CH) is a common disease that originates from long‐term heart pressure overload and finally leads to failure. Recently, long non‐coding RNAs (lncRNAs) have attracted attention because they broad crucial functions in regulating complex biological processes. Some studies had found lncRNAs play vital roles cardiovascular diseases. However, the function mechanism of CH not been elucidated. In our study, investigate potential CH, Hypertrophy‐associated LncRNAs‐Protein...
Abstract Metabolic pathway analysis is a popular strategy for comprehensively researching metabolites and genes of interest associated with specific diseases. However, the traditional identification methods do not accurately consider combined effect these interesting molecules neglects expression correlations or topological features embedded in pathways. In this study, we propose powerful method, Subpathway-CorSP, identifying metabolic subpathway regions. This method improved on original by...