A5056417543- Heavy Metal Exposure and Toxicity
- Mercury impact and mitigation studies
- Biochemical effects in animals
- Heme Oxygenase-1 and Carbon Monoxide
- Selenium in Biological Systems
- Air Quality and Health Impacts
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Trace Elements in Health
- Biochemical Acid Research Studies
- Endoplasmic Reticulum Stress and Disease
- Parkinson's Disease Mechanisms and Treatments
- Genomics, phytochemicals, and oxidative stress
- Alzheimer's disease research and treatments
- Sirtuins and Resveratrol in Medicine
- Aquaculture disease management and microbiota
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Energy and Environment Impacts
- Mitochondrial Function and Pathology
- Immune Response and Inflammation
- Connexins and lens biology
- Alcoholism and Thiamine Deficiency
China Medical University
2016-2025
The First People's Hospital of Tianmen
2019-2025
Ministry of Education of the People's Republic of China
2017-2023
Second Affiliated Hospital of Dalian Medical University
2022
Second Affiliated Hospital of Zhejiang University
2019
Northwest Normal University
2017
China Agricultural University
2005-2010
Hospital for Sick Children
2010
Methyl-mercury (MeHg) is a dangerous environmental contamination biotransformed from mercury or inorganic compounds in waterways, which induces severe toxic effects central nervous system. Oxidative stress involved various ways of intracellular physiological pathological processes including neuronal apoptosis. For understanding the that oxidative participating MeHg-induced apoptosis, current study attempted to explore on endoplasmic reticulum (ER) and mitochondria function, especially...
Mercury (Hg) represents a ubiquitous environmental heavy metal that could lead to severe toxic effects in variety of organs usually at low level. The present study focused on the liver oxidative stress, one most important roles playing Hg hepatotoxicity, by evaluation different concentrations mercuric chloride (HgCl 2 ) administration. Moreover, protective potential curcumin against hepatotoxic was also investigated. Eighty-four rats were randomly divided into six groups for three-days...
UV-B radiation may be an important risk factor in cataract etiology. After exposure to radiation, cells show imbalances the repair of DNA damage, which induce changes levels certain proteins, including alpha-crystallin, is most abundant protein lens and crucial for maintenance transparency. Lanosterol synthase (LSS), essential rate-limiting enzyme cholesterol biosynthesis, might play significant roles oxidative stress However, LSS UV-B-induced apoptosis are not well understood. Therefore, we...
While the pernicious effects of outdoor air pollution on cognitive ability have been previously examined, evidence regarding household is scarce. Using data from Chinese Longitudinal Healthy Longevity Survey, we explored relationship between cooking with biomass fuel and impairment decline using a Cox proportional hazards model. We further assessed correlation fuels score generalized estimating equation. Cognitive was measured based version Mini-Mental State Examination (MMSE) defined as...
Methylmercury (MeHg) is a ubiquitous environmental contaminant that could induce oxidative stress and an indirect glutamate (Glu)-mediated excitotoxicity. However, the underlying mechanisms through which MeHg affects central nervous system have not been fully elucidated, little has known of interaction between Glu dyshomeostasis in neurotoxicity. Therefore, rats were administrated with different concentrations (0, 4, 12 μmol/kg) to evaluate neurotoxic effects cerebral cortex. Moreover, we...
Abstract Overexposure to manganese (Mn) has been known induce nitrosative stress. The dysregulation of autophagy implicated in nitric oxide (NO) bioactivity alterations. However, the mechanism Mn‐induced autophagic is unclear. protein Bcl‐2 was considered as a key role that could participate signaling regulation. To further explore whether S‐nitrosylation involved dysregulation, we treated human neuroblastoma (SH‐SY5Y) cells with Mn and pretreated 1400 W, selective iNOS inhibitor. After were...
Abstract Overexposure to manganese (Mn) has been known induce alpha‐synuclein (α‐Syn) oligomerization, which is degraded mainly depending on endoplasmic reticulum stress (ER stress) and autophagy pathways. However, little data reported the cross‐talk between ER Mn‐induced α‐Syn oligomerization. To explore relationship autophagy, we used 4‐phenylbutyric acid (4‐PBA, inhibitor), rapamycin (Rap, activator) 3‐methyladenine (3‐MA, inhibitor) in mice model of manganism. After 4 weeks treatment...