A5100431998- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Nerve injury and regeneration
- Nuclear Receptors and Signaling
- Neuroscience and Neuropharmacology Research
- Ginkgo biloba and Cashew Applications
- Cellular transport and secretion
- Angiogenesis and VEGF in Cancer
- Cholinesterase and Neurodegenerative Diseases
- Lysosomal Storage Disorders Research
- Public Health and Nutrition
- Enhanced Recovery After Surgery
- Collagen: Extraction and Characterization
- Botulinum Toxin and Related Neurological Disorders
- Silk-based biomaterials and applications
- Gastric Cancer Management and Outcomes
- Cancer Research and Treatments
- Pain Mechanisms and Treatments
- Cell Adhesion Molecules Research
- Heavy Metal Exposure and Toxicity
- Conducting polymers and applications
- Neurological disorders and treatments
- Biochemical and biochemical processes
- biodegradable polymer synthesis and properties
Wuhan Polytechnic University
2024
Henan University of Science and Technology
2024
Zhengzhou University
2022-2023
First People’s Hospital of Jingmen
2018-2022
China Medical University
2013-2021
Xian Yang Central Hospital
2018
Zhengzhou Central Hospital
2015
Abstract Manganese (Mn) overexposure produces long-term cognitive deficits and reduces brain-derived neurotrophic factor (BDNF) in the hippocampus. However, it remains elusive whether Mn-dependent enhanced alpha-synuclein (α-Syn) expression, suggesting a multifaceted mode of neuronal toxicities, accounts for interference with BDNF/TrkB signaling. In this study, we used C57BL/6J WT α-Syn knockout (KO) mice to establish model manganism found that Mn-induced impairments spatial memory synaptic...
Abstract Overexposure to manganese (Mn) has been known induce alpha‐synuclein (α‐Syn) oligomerization, which is degraded mainly depending on endoplasmic reticulum stress (ER stress) and autophagy pathways. However, little data reported the cross‐talk between ER Mn‐induced α‐Syn oligomerization. To explore relationship autophagy, we used 4‐phenylbutyric acid (4‐PBA, inhibitor), rapamycin (Rap, activator) 3‐methyladenine (3‐MA, inhibitor) in mice model of manganism. After 4 weeks treatment...
Objective. The objective is to explore the effect of comprehensive nursing on recovery gastrointestinal function in patients undergoing an abdominal operation. Methods. Sixty surgery our hospital from January 2019 April 2021 were enrolled. arbitrarily assigned into control group and research group. former received routine latter nursing. Nursing satisfaction, function, POMS-SF score, nutrition risk incidence adverse reactions, quality life scores compared. Results. satisfaction was higher...
The aim of this study was to investigate the effect lysosomal and ubiquitin-proteasome system dysfunction on abnormal aggregation α-synuclein, analyze its role in pathogenesis Parkinson's disease (PD). PC12 cells subjected nerve growth factor-induced differentiation were used as cell model dopaminergic neurons, proteasomal inhibitors trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane (E64) and, respectively, exclusively combination treat cells. viability metabolic state assessed using...
Abstract Overexposure to manganese (Mn) is widely known induce alpha‐synuclein (α‐Syn) oligomerization, which has been attributed the oxidative damage of α‐Syn protein. Trehalose shown autophagy and serve as a chemical chaperone, but little information reported about its effect on Mn‐induced oligomerization. In this study, we investigate whether trehalose can effectively interfere with using different concentrations (2% 4% (g/vol [mL])) in mouse model manganism. After 6 weeks exposure Mn,...
At present, the effect of ganglioside combined with Jiaji electroacupuncture (Jiaji EA) on SCI still remains unclear. This study explores Nogo/NgR signal pathway in spinal cord tissue injury (SCI) rats. Basso Beattie Bresnahan (BBB) score was used to evaluate function after modeling and 14 days post treatment. RT-qPCR western blot were performed expression levels targets tissue. After treatment, BBB scores EA group, group combination all improved. The IL-1β, IL-6 TNF-α significantly lower...
Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive neuronal loss in different brain regions, including the dopaminergic (DA) neurons of substantia nigra pars compacta (SNc). The aggregation α-synuclein (α-Syn) plays an essential role progression PD-related neuron toxicity. In this study, bioinformatic analysis was used to confirm differentially expressed genes between patients with PD and healthy donors. Immunofluorescence study α-Syn. Flow cytometry...
Abstract Parkinson’s disease is a chronic neurodegenerative condition accompanied by variety of motor and non-motor clinical symptoms. Diagnosing presents many challenges, such as excessive reliance on subjective scale scores lack objective indicators in the diagnostic process. Developing efficient convenient methods to assist doctors diagnosing necessary. In this paper, we study skeleton sequences obtained from gait videos Parkinsonian patients for early detection disease. We designed...
Objective To compare the short-term effects of FOLFOXIRI and SOX chemotherapy regimens in treatment advanced colorectal cancer. Methods A retrospective study was conducted. The clinical data 71 patients with cancer admitted from January 2013 to 2015 Jingmen Second People's Hospital were analyzed. According different regimens, divided into two groups. group treated regimen (oxaliplatin+S-1), (oxaliplatin + irinotecan 5-fluorouracil). After 4 courses treatment, efficacy adverse...