A5101799271- Pancreatic function and diabetes
- Ion Transport and Channel Regulation
- Cytokine Signaling Pathways and Interactions
- Cystic Fibrosis Research Advances
- Genetics and Neurodevelopmental Disorders
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Lipids, and Metabolism
- Trace Elements in Health
- Advanced Steganography and Watermarking Techniques
- Chaos-based Image/Signal Encryption
- Advanced Drug Delivery Systems
- Nanoparticles: synthesis and applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Computational and Text Analysis Methods
- Clinical Reasoning and Diagnostic Skills
- Cloud Data Security Solutions
- Medical and Biological Ozone Research
- Traditional Chinese Medicine Analysis
- Sirtuins and Resveratrol in Medicine
- Drug Transport and Resistance Mechanisms
- Pharmaceutical Practices and Patient Outcomes
- Ginseng Biological Effects and Applications
- Heavy Metal Exposure and Toxicity
- Digital Media Forensic Detection
University of Idaho
2024-2025
Jouf University
2025
National Guard Health Affairs
2021-2024
King Saud University
2017-2024
Ministry of Health
2024
King Abdulaziz Medical City
2023
Imam Abdulrahman Bin Faisal University
2023
King Saud bin Abdulaziz University for Health Sciences
2020-2022
Wright State University
2014-2020
University of Kansas
2015-2020
Hepatocellular carcinoma (HCC) exhibits high mortality rates in the advanced stage (>90 %). Sorafenib (SORA) is a targeted therapy approved for treatment of HCC; however, reported response rate to such therapeutic suboptimal (<3%). Piperine (PIP) an alkaloid demonstrated exert direct tumoricidal activity HCC and improve pharmacokinetic profiles anticancer drugs including SORA. In this study, we developed strategy efficacy outcomes using PIP as add-on support first-line SORA biodegradable...
The increasing prevalence of antimicrobial-resistant (AMR) bacteria along with the limited development antimicrobials warrant investigating novel antimicrobial modalities. Emerging inorganic engineered nanomaterials (ENMs), most notably silver nanoparticles (AgNPs), have demonstrated superior properties. However, AgNPs, particularly those small size, could exert overt toxicity to mammalian cells. This study investigated whether combining AgNPs and conventional would produce a synergistic...
Ransomware is a type of malware that leverages encryption to execute its attacks. Its continuous evolution underscores dynamic and ever-changing nature. The evolving variants use varying timelines launch attacks associate them with attack patterns. Detecting early also leads incomplete To develop an detection model for behavioral drifting ransomware attacks, should be able detect variants. consider the problem generalize behavior significant features comprehensively. Existing solutions were...
The confluence of the Internet Things (IoT) and cloud computing heralds a paradigm shift in data-driven applications, promising unprecedented insights automation across critical sectors like healthcare, smart cities, industrial automation. However, this transformative synergy introduces complex tapestry security vulnerabilities stemming from intrinsic resource limitations IoT devices inherent complexities infrastructures. This survey delves into escalating threats—from conventional data...
Radix Salviae Miltiorrhizae (RSM), a well-known traditional Chinese medicine, has been shown to inhibit tumorigenesis in various human cancers. However, the anticancer effects of RSM on hepatocellular carcinoma (HCC) and underlying mechanisms action remain be fully elucidated. In this study, we aimed elucidate molecular treatment HCC using network pharmacology approach. vivo vitro experiments were also performed validate therapeutic HCC. total, 62 active compounds from 72 HCC-related targets...
Abstract Intracellular chloride concentration ([Cl − ] i ) in pancreatic β-cells is kept above electrochemical equilibrium due to the predominant functional presence of Cl loaders such as Na + K 2Cl co-transporter 1 ( Slc12a2 over extruders unidentified nature. Using molecular cloning, RT-PCR, Western blotting, immunolocalization and vitro assays, we establish that “neuron-specific” 2 (KCC2, Slc12a5 expressed several endocrine cells islet, including glucagon secreting α-cells, but...
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown strong and explicit cancer cell-selectivity, which results in little toxicity toward normal tissues, been recognized as a potential, relatively safe anticancer agent. However, several cancers are resistant to the apoptosis induced by TRAIL. A recent study found that shikonin b (alkannin, 5,8-dihydroxy-2-[(1S)-1-hydroxy-4-methylpent-3-en-1-yl]naphthalene-1,4-dione) might induce TRAIL-resistant cholangiocarcinoma...
Autism spectrum disorders (ASD) are neurobehavioral disabilities characterized by impaired social interactions, poor communication skills, and restrictive/repetitive behaviors. Cadmium is a common heavy metal implicated in ASD. In this study, we investigated the effects of Cd exposure on BTBR T+ Itpr3tf/J (BTBR) mice, an ASD model. We looked for changes repetitive behaviors sociability through experiments. also explored molecular mechanisms underlying exposure, focusing proinflammatory...
The Na + K 2Cl − cotransporter-1 ( Slc12a2 , NKCC1) is widely distributed and involved in cell volume/ion regulation. Functional NKCC1 locates the plasma membrane of all cells studied, particularly basolateral most polarized cells. Although mechanisms sorting are poorly understood, it assumed that N-glycosylation necessary. Here, we characterize expression, N-glycosylation, distribution COS7 We show ~25% complex N-glycosylated whereas rest corresponds to core/high-mannose hybrid-type forms....
Recent studies have demonstrated that trans-3, 5, 4'-Trimethoxystilbene (TMS), a novel derivative of resveratrol, may suppress the foam cells formation and restrain atherosclerosis in vitro vivo. Herein, molecular mechanisms underlying protective effects TMS against are further delineated.In present study, cholesterol-lowering macrophage-derived cell by animal studies, Oil Red O staining, lipid uptake as well efflux analysis, explored. Real-time PCR, western blotting luciferase reporter...
Cystic fibrosis (CF) is due to mutations in the CF-transmembrane conductance regulator ( CFTR ) and CF-related diabetes (CFRD) its most common co-morbidity, affecting ~50% of all CF patients, significantly influencing pulmonary function longevity. Yet, complex pathogenesis CFRD remains unclear. Two non-mutually exclusive underlying mechanisms have been proposed CFRD: i damage endocrine cells secondary severe exocrine pancreatic pathology ii intrinsic β-cell impairment secretory response...
The incorporation of engineered nanomaterials (ENMs) in biomedical and consumer products has been growing, leading to increased human exposure. Previous research was largely focused on studying direct ENM toxicity unrealistic high-exposure settings. This could result overlooking potential adverse responses at low subtoxic exposure levels. study investigated cellular outcomes concentrations zinc oxide (ZnONPs) or nickel (NiONPs) nanoparticles the Raw 264.7 cells, a macrophage-like cell model....
Steganography has become one of the most significant techniques to conceal secret data in media files. This paper proposes a novel automated methodology achieving two levels security for videos, which comprise encryption and steganography techniques. The enhances level without affecting accuracy capacity videos. In first level, is encrypted based on Advanced Encryption Standard (AES) algorithm using Java language, renders unreadable. second concealed video frames (images) FPGA hardware...
Abstract Background To establish children-specific reference values for the Y-balance test (YBT) and Isometric muscle strength in school children of Saudi Arabia to elucidate relationship between YBT performance lower limb strength. Materials & Methods Healthy School (51 males) aged 12–15 years volunteered participate this study. Participants completed maximal isometric testing knee extensors flexors a single session. Descriptive statistics were used compute values. Paired t-tests...
This study provides a comprehensive review and comparative analysis of existing Information Flow Tracking (IFT) tools which underscores the imperative for mitigating data leakage in complex cloud systems. Traditional methods impose significant overhead on Cloud Service Providers (CSPs) management activities, prompting exploration alternatives such as IFT. By augmenting consumer subsets with security tags deploying network monitors, IFT facilitates detection prevention leaks among tenants....
Big conductance potassium (BK) channels contribute to K+ flow and electrical behavior in many cell types. Mice made null for the gene (Kcnma1) producing BK channel (BKKO) exhibit numerous deficits physiological functions. Breeding mice lacking a single allele of Kcnma1 (C57BL/6J background) had litter sizes approximately eight pups. For period maternal care (P0–P21), pup deaths peaked at P1 with second less severe interval death peaking near P13. Early were twice as likely during 20-month...