Picolinamide has first been employed as a traceless directing group for the cobalt-catalyzed oxidative annulation of benzylamides with alkynes to synthesize isoquinolines through C–H/N–H bonds activation. Oxygen is used terminal oxidant. This protocol exhibits good functional tolerance and excellent regioselectivity. Both internal can be efficiently applied this catalytic system substrates.

A novel strategy to 4(3<italic>H</italic>)-quinazolinones from ketoalkynes and <italic>o</italic>-aminobenzamides through C–C triple bond fragmentation two C–N formations under external oxidant metal free conditions.

A method for the regiodivergent and stereoselective hydrosilylation of basic industrial feedstock isoprene with unactivated silanes has been developed using earth-abundant iron catalysts. The manipulation regioselectivity relies on fine modification coordination geometry center. While a bidentate pyridine imine ligand promoted formation allylic through 4,1-addition, selectivity 3,4-adduct homoallylic was observed tridentate nitrogen ligand. Experimental studies analysis were carried out to...

A convenient "one-pot" base-promoted synthesis of polysubstituted pyridines from 1-arylethylamines and ynones through the direct β-C(sp(3))-H functionalization enaminones under metal-free conditions has been developed. An intermolecular Michael addition reaction an intramolecular condensation were involved in this procedure, which features high regioselectivity, efficiency, environmental friendliness. Various provided up to 92% yield for 34 examples.

Multicomponent reactions, particularly those entailing four or more reagents, have presented a longstanding challenge due to the inherent complexities associated with balancing reactivity, selectivity, and compatibility. In this study, we describe palladium-catalyzed multi-component fluoroalkylative carbonylation of 1,3-enynes. A series products featuring three active functional groups-allene, fluoroalkyl, carboxyl, were efficiently selectively integrated in single chemical operation....

Abstract Compared to the methods that rely on complex and structurally unique substrates for synthesis of heterocyclic compounds through intra‐ intermolecular cyclization, strategies starting from simple readily available substrates, combined with finely tuned catalytic system achieve different chemoselectivity, offer significant advantages in terms efficiency, cost‐effectiveness, versatility. Herein, we present a palladium‐catalyzed carbonylation strategy enables selective efficient...

Efficiently constructing structurally diverse and complex organic molecules through selective catalytic functionalization is a central goal in synthetic chemistry, yet achieving precise control over multiple reactive centers multisite substrates remains formidable challenge. Building on foundational advances single- dual-selective transformations, we report multimodal strategy for the carbonylation of 1,3-enynes, versatile class substrates. Through meticulous fine-tuning conditions, our...

α,β-Unsaturated amides play a vital role in natural products, pharmaceuticals, organic synthesis, and functional materials. Herein, we disclosed regio- stereoselective hydroaminocarbonylation of unsymmetrical internal alkynes via palladium catalysis to synthesize α,β-unsaturated amides. This protocol features excellent exclusive (E)-stereoselectivity, high atom step-economy, broad substrate scope, group tolerance.

In this communication, a palladium-catalyzed regio- and stereoselective carbonylation of 2-trifluoromethyl-1,3-enynes to afford multisubstituted conjugated dienes has been realized. This protocol features excellent exclusive (E)-stereoselectivity broad substrate scope with both amines alcohols as the suitable reaction partners shown promising functional group tolerance.

An atom-economical, regiodivergent hydrosilylation reaction of isoprene was developed using an Earth-abundant cobalt catalyst through variation ligands.

Abstract Arene homologation employing internal alkynes as coupling partners and 2‐pyridyloxyl directing group through dual C−H bond functionalization was accomplished using (pentamethylcyclopentadienyl)‐rhodium(III) chloride dimer a pre‐catalyst. This protocol proved tolerant of synthetically valuable functional groups, provided an expeditious access to highly congested naphthalene derivatives in moderate good yields. Furthermore, the pyridyl moiety could be removed furnish versatile ( OH...

An efficient hydroamidation of benzylamides with internal alkynes catalyzed by Ru(II) has been developed. Various (E)-enamides were afforded in up to 95% yield for 28 examples. The protocol features excellent regio- and stereoselectivity, widely functional group tolerance, easily accessible starting materials.

A base-promoted cascade reaction for the regiospecific synthesis of substituted 3-hydroxyisoindolinones under transition-metal-free conditions is developed. The base-mediated C-C bond coupling and N-α-sp3C-H hydroxylation are involved in this procedure, which features high regioselectivity, efficiency, environmental friendliness. Various 3-hydroxyisoindolinones, including some bioactive molecules, were provided up to 93% yield 28 examples.

N-Substituted formamides as nucleophiles react with in situ-generated 1,4-oxazepines from N-propargylic β-enaminones followed by spontaneous N-deformylation to deliver densely substituted 2-aminopyridines good yields (31–88%). The formyl group is found be a superior traceless activating of free amines and would ultimately removed situ. This reaction proceeds smoothly at room temperature, the presence NaOH sole additive, without protection atmosphere generates H2O sodium formate byproducts.

Abstract A method for the regiodivergent and stereoselective hydrosilylation of basic industrial feedstock isoprene with unactivated silanes has been developed using earth‐abundant iron catalysts. The manipulation regioselectivity relies on fine modification coordination geometry center. While a bidentate pyridine imine ligand promoted formation allylic through 4,1‐addition, selectivity 3,4‐adduct homoallylic was observed tridentate nitrogen ligand. Experimental studies analysis were carried...

Direct conversion of raw materials to fine chemicals is greatly economically influential. We developed a non-expensive cobalt-catalyzed multicomponent carbonylative reaction for the synthesis γ-aryl carboxylic acid esters from readily available methylarene, ethylene, and CO, which are widely found in multiple FDA-approved drugs.

The synthesis of amides <italic>via</italic> base-promoted cleavage the C(sp)–C(CO) bond ynones with aliphatic primary and secondary amines is reported.

The Rh-catalyzed ortho-C–H carbenoid insertion reaction of diarylazines with diazo compounds has been developed. A wide range ortho-substituted have obtained in moderate to high yields regioselectivity at room temperature. hydrolysis the products could release ketones or aldehydes, giving access aromatic 1,5-keto-diesters as valuable synthons for further chemical transformations.

An Ir(iii)-catalyzed regioselective C-H amidation of anilines with sulfonyl azides is described. The developed protocol has good compatibility diverse functional groups, efficiently providing the monoamidated products to excellent yields under mild reaction conditions. Furthermore, 2-pyrimidyl and moieties in amidated can readily be removed, offering synthetically useful 1,2-diaminobenzene scaffold.

An atom-economical, regio- and enantioselective allylic alkylation of pyrazol-5-ones with alkynes was developed under rhodium catalysis.

The selective and effective conversion of low-cost simple bulk chemicals into high value-added products through catalytic strategy has a wide range practical significance. Here, palladium-catalyzed method for the direct efficient dicarbonylation amines with basic industrial feedstock ethylene to imide been developed. Moderate excellent yields desired imides can be produced from readily available in straightforward manner.

An efficient strategy for the synthesis of acrylamides via palladium-catalyzed carbonylation, using 1,2-dichloroethane and amines as starting materials has been developed.