A5029457858- Catalytic C–H Functionalization Methods
- Fluorine in Organic Chemistry
- Carbon dioxide utilization in catalysis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Analysis
- Catalytic Cross-Coupling Reactions
- Sulfur-Based Synthesis Techniques
- Radical Photochemical Reactions
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Reactions
- Catalytic Alkyne Reactions
- Click Chemistry and Applications
- Asymmetric Synthesis and Catalysis
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Organoboron and organosilicon chemistry
- Synthesis and Biological Evaluation
- Gastroesophageal reflux and treatments
- Thermoregulation and physiological responses
- Helicobacter pylori-related gastroenterology studies
- Histone Deacetylase Inhibitors Research
- Axial and Atropisomeric Chirality Synthesis
- Synthesis and Reactivity of Heterocycles
Dalian Institute of Chemical Physics
2021-2024
Dalian National Laboratory for Clean Energy
2021-2024
Chinese Academy of Sciences
2021-2024
Shanghai University of Engineering Science
2023-2024
Renmin University of China
2017-2023
Leibniz Institute for Catalysis
2019-2022
Rostocker Zentrum zur Erforschung des Demografischen Wandels
2020
Taian City Central Hospital
2013-2015
Transition-metal-catalyzed multi-component carbonylation represents an efficient strategy for the preparation of various functionalized carbonyl-containing compounds. Herein, we report a general palladium-catalyzed perfluoroalkylative unactivated alkenes using inexpensive and readily available carbon monoxide as C1 source perfluoroalkyl halides coupling partner. A wide range phenols alcohols were transformed into corresponding β-perfluoroalkyl esters in high yields with broad functional...
Given the prevalence of amide backbones in marketed pharmaceuticals and their ubiquity as critical binding units natural peptides proteins, it remains important to develop novel methods construct bonds. We report here a general method for anti-Markovnikov hydroaminocarbonylation unactivated alkenes under mild conditions, using copper catalysis combination with hydroxylamine electrophile reagents poly(methylhydrosiloxane) (PMHS) cheap environmentally friendly hydride source. The reaction...
Abstract Multi‐component carbonylation of olefins, a reaction that installs both carbon–carbon(heteroatom) bond and carbonyl group across the double bond, is an attractive strategy for alkene functionalization. Herein, we developed novel nickel‐catalyzed four‐component olefins with ethers under low CO gas pressure. Using alcohols amines as partner, diverse γ ‐oxy‐substituted esters amides were produced in good yields excellent functional tolerance. Notably, Naftidrofuryl, medicine treatment...
Abstract Fluorinated heterocycles play a vital role in pharmaceutical and agrochemical industries. Hence, rapid efficient construction of fluorinated remains highly demanded. Herein, difluoroalkylative carbonylative cyclization unactivated alkenes ethylene gas enabled by palladium catalysis has been developed for the first time toward synthesis α-carbonyl difluoro-modified glutarimides. This procedure can also be applied to GeMigliptin which is medicine approved treatment type 2 diabetes mellitus.
Abstract Herein, we developed a copper‐catalyzed approach for the remote C( sp 3 )−H alkynylation of N ‐fluoro‐sulfonamides. With Cu(OTf) 2 as catalyst, carbon radical which generated from nitrogen radical‐mediated 1,5‐hydrogen atom transfer, go through an addition/fragmentation reaction with various acetylene sulfones. A variety internal alkynes were synthesized in high yield and regioselectivity. Notably, celecoxib‐derived substrate can also gave corresponding functionalized product good...
Abstract γ-Amino acids and peptides analogues are common constituents of building blocks for numerous biologically active molecules, pharmaceuticals, natural products. In particular, γ-amino providing with better metabolic stability than α-amino acids. Herein we report a multicomponent carbonylation technology that combines readily available amides, alkenes, the feedstock gas carbon monoxide to build architecturally complex functionally diverse acid derivatives in single step by...
A new methodology for the carbonylative transformation of N-fluoro-sulfonamides into N-sulfonyl-β-homoproline esters has been described. In presence a catalytic amount Cu(OTf)2, range β-homoproline derivatives were prepared in moderate to good yield. The reaction proceeds via intramolecular cyclization and intermolecular carbonylation free carbon radical. Notably, this procedure offers possibility build potential functionalized bioactive molecules.
An interesting palladium-catalyzed difluoroalkylative carbonylation of aryl olefins has been developed. A wide range were transformed into the corresponding difluoropentanedioate compounds with good functional-group tolerance and excellent regioselectivity.
Difunctionalization of alkenes is an efficient strategy for the synthesis complex compounds from readily available starting materials. Herein, we developed a copper-catalyzed visible-light-mediated trichloromethylative carbonylation ethylene by employing commercially CCl
Herein, we disclose an interesting iron-catalyzed approach for the carbonylation of a tertiary carbon radical. The radical generated from 1,5-hydrogen atom transfer can be captured by CO gas smoothly. Various six-membered lactams were constructed chemo-selectively in high yields.
Chiral amides are common and effective structural motifs found in many pharmaceuticals biologically active molecules. Despite their importance, existing synthetic methods predominantly employed for the synthesis of α-amides β-amides. The remote chiral amides, characterized by distal stereocenters, typically requires intricate steps conducted under demanding conditions. Here, we present a general procedure copper-catalyzed enantioselective γ-chiral employing reductive relay...
A series of axially chiral bis-1,2,3-triazol-5-ylidene Au(I) complexes (R)-8a–g and one mono-1,2,3-triazol-5-ylidene complex (R)-9a were prepared from commercially available (R)-binaphthyl-2,2-diamine (BINAM) compound, in which, transmetalation bis(MIC)-bis[Ag(I)] intermediates to the corresponding employed as key synthetic step. The structures these MIC–Au(I) diversified by using different alkyne reagents copper catalyzed azide–alkyne cycloaddition (CAAC) Three Ag(I) complexes, (R)-7a,...
Abstract Herein, a convenient procedure on iron‐catalyzed radical‐mediated synthesis of dihydronaphthalenones from oxime esters has been developed. By using iron salt as green and inexpensive catalyst, various α‐aryl were transformed into the corresponding in moderate to good yields with high chemo‐selectivities. The reaction proceeds via 1,5‐hydrogen atom transfer then intramolecular radical cyclization sequence. magnified image
Herein, a new method of iron-catalyzed carbonylative cyclization γ,δ-unsaturated aromatic oxime esters to functionalized pyrrolines has been developed. By using readily available substrates, 32 examples were prepared in moderate good yields. Notably, reduction and cycloaddition reactions the obtained product given as well.
The synthesis of α-carbonyl-α′-amide sulfoxonium ylides by Pd/C-catalyzed carbonylative transformation azides with α-carbonyl has been studied. This method offers a direct approach to produce synthetically useful in high efficiency. By using readily available substrates, 39 examples products were prepared good yields outstanding functional group compatibility. An example converting the obtained ylide into corresponding 1,3-dicarbonyl compound given as well.
A new method of low-cost copper-catalyzed carbonylative cyclization for preparing pyrrolidine-containing amides from γ,δ-unsaturated aromatic oxime esters and amines has been described.
An efficient iron-catalyzed carbonylative cyclization of γ,δ-unsaturated aromatic oxime esters with amines has been developed.
Transition-metal-catalyzed multicomponent carbonylation is one of the most efficient strategies to construct carbonyl-containing compounds. Herein, a palladium-catalyzed four-component perfluoroalkylation/aminocarbonylation unactivated alkenes with perfluoroalkyl halides, and amines was developed. A wide range substrates, including anilines, alkylamines, sulfonamides, hydrazines are all suitable reaction partners for this catalyst system, resulting in various β-perfluoroalkyl amides good...