Although recent short-term cross-sectional studies have revealed that chronic periodontitis (CP) may be a risk factor for increased cognitive impairment in patients with Alzheimer's disease (AD), systematic reviews and long-term longitudinal provided less clear evidence regarding the relationship between CP AD. Therefore, we conducted retrospective cohort study using National Health Insurance Research Database (NHIRD) of Taiwan to determine whether are at developing AD.We matched-cohort...

Recently, a few small reports with short follow-up period have shown clinical benefits of platelet-rich plasma (PRP) for peripheral neuropathy including one pilot study and small, non-randomized trial in patients carpal tunnel syndrome (CTS). Therefore, we conducted randomized, single-blind, controlled to assess the 6-month effect PRP CTS. Sixty unilateral mild-to-moderate CTS were randomized into two groups 30, namely control groups. In group, injected dose 3 mL using ultrasound guidance...

The cause-effect relation between periodontal inflammatory disease (PID) and Parkinson's (PD) remains uncertain. purpose of our study was to investigate the association PID PD.We conducted a retrospective matched-cohort by using Taiwan's National Health Insurance Research Database. We identified 5,396 patients with newly diagnosed during 1997-2004 10,792 cases without matching sex, age, index year (occurrence PID), comorbidity. Cox proportional hazard regression used evaluate risk subsequent...

The treatment of adhesive capsulitis (AC) is a well-known, complicated, and long process. Recent studies have shown that pulsed radiofrequency (PRF) lesioning the suprascapular nerve (SSN) using fluoroscopy- or computed tomography-guided technique can alleviate shoulder pain. However, there are no PRF SSN in patients with AC ultrasound-guided (UG) techniques, except for 2 case reports. In this study, we compared effect physical therapy alone UG technique.Sixty were included study. Patients...

No studies comparing the effects of platelet-rich plasma (PRP) injection and placebo in bilateral knee osteoarthritis same patient, or discussing muscle strength after PRP injection, have been published.Twenty patients with were eligible, 40 knees randomized into two groups: (knees [right left by a coin toss] receiving single intra-articular injection) saline group (the contralateral which 4-mL normal was administered). The primary outcome measure Western Ontario McMaster's Universities...

The protective effect of dental scaling in Parkinson's disease (PD) remains inconclusive. aim this study was to analyze the association between and development PD. A retrospective nested case-control performed using National Health Insurance Research Database Taiwan. authors identified 4765 patients with newly diagnosed PD from 2005 2013 19,060 individuals without by matching sex, age, index year. In subgroup 1, aged 40⁻69 years, periodontal inflammatory (PID) showed a against development,...

Abstract Recently, extracorporeal shock wave therapy (ESWT) has been shown to be a novel for carpal tunnel syndrome (CTS). However, previous studies did not examine the diverse effects of different-session ESWT different-grades CTS. Thus, we conducted randomized, single-blind, placebo-controlled study. Sixty-nine patients (90 wrists) with mild moderate CTS were randomized into 3 groups. Group A and C received one session radial (rESWT) sham eESWT per week consecutive weeks, respectively; B...

The entrapment of peripheral nerves is associated with chronic neuroinflammation and neuropathic pain, perineural injection therapy glucose emerging as an effective treatment for neuropathy. However, the mechanism underlying pharmacological effect on remains unclear. One hypothesized mechanisms that reduces neurogenic inflammation. Therefore, we investigated effects high concentrations cytokine-induced in vitro. Human SH-SY5Y neuronal cells were challenged 10 ng/mL TNF-α 16 h subsequently...

Neuroinflammation is a key feature in the pathogenesis of entrapment neuropathies. Clinical trial evidence suggests that perineural injection glucose water at sites has therapeutic benefits beyond mere mechanical effect. We previously demonstrated 12.5-25 mM restored normal metabolism human SH-SYFY neuronal cells rendered metabolically inactive from TNF-α exposure, common initiator neuroinflammation, and reduced secondary elevation inflammatory cytokines. In present study, we measured...

Background: D-glucose (dextrose) is used as a 5000–25,000 mg% solution in the injection-based pain therapy known dextrose prolotherapy (DPT). The number of peer-reviewed clinical trials supporting its use growing. However, mechanism action unknown, limiting further research. A commonly expressed theory that hyperosmotic injection induces inflammation, initiating healing-specific inflammatory cascade. In vitro study models have continuous exposure to high concentration dextrose. But rate...

Recently, studies have reported that extracorporeal shock wave therapy (ESWT) is a safe, noninvasive, alternative treatment for spasticity. However, the effect of ESWT on spasticity cannot be determined, because most to date enrolled small patient numbers and lacked placebo-controlled groups and/or long-term follow-up. In addition, whether varying number sessions would affect duration therapeutic has not been investigated in single study. Hence, we performed prospective, randomized, blind,...

Abstract Objective Perineural injection therapy with 5% dextrose water is progressively becoming a mainstream method for treating carpal tunnel syndrome. However, its long-term outcome still unknown. Hence, the purpose of this retrospective study was to investigate after perineural using water. Methods A total 185 patients diagnosed carpel syndrome at least 1 year post-therapy were enrolled. All underwent ultrasound-guided 10 ml outpatient department. In structured telephone interview, asked...

Objective We assessed the therapeutic efficiency of ultrasound-guided pulsed radiofrequency (PRF) treatment median nerve in patients with carpal tunnel syndrome (CTS). Methods conducted a prospective, randomized, controlled, single-blinded study. Forty-four CTS were randomized into intervention or control groups. Patients group treated PRF and night splint, was prescribed splint alone. Primary outcome onset time significant pain relief using visual analog scale (VAS), secondary outcomes...

Patients with failure of primary surgery for carpal tunnel syndrome (CTS) present a frustrating clinical problem because there are no relevant treatment guidelines, and the effect current conservative management or revision is unsatisfactory. Hydrodissection 5% dextrose emerging as an effective CTS may be alternative method persistent recurrent post-surgical CTS. We retrospectively investigated long-term effectiveness hydrodissection Thirty-six forty consecutively-treated patients either...

Interest in perineural platelet-rich-plasma (PRP) injections for the treatment of carpal tunnel syndrome (CTS) has increased recent years. However, evidence supporting long-term effectiveness PRP is lacking. Therefore, aim our cross-sectional cohort study was to investigate results CTS.Eighty-one patients diagnosed with CTS any grade who received a single injection at least 2 years prior were enrolled. Through structured telephone interviews, all asked their post-injection outcomes compared...

Recent studies have suggested that the combined injection of platelet-rich plasma (PRP) and hyaluronic acid (HA) may additive benefits for knee osteoarthritis over PRP alone, but there is insufficient evidence to support this injection. Moreover, simultaneous HA offset effect. Hence, aim prospective, randomized, double-blind study was assess their efficacy with a novel protocol. Forty-six subjects unilateral were randomized receive either single-dose (intervention group) or normal saline...

To investigate the association between temporomandibular disorders (TMD) and rheumatoid arthritis (RA), as well potential risk factors for TMD preventive effect of medications on TMD, by using Taiwan National Health Insurance Research Database.In total, 17,317 patients newly diagnosed with RA matched controls without were followed up from 2000 to 2010. Cox regression was used determine developing TMD. Kaplan-Meier curve log-rank test cumulative in effects antirheumatic medications.Cox showed...