A5074199174- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- interferon and immune responses
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- Bacteriophages and microbial interactions
- Animal Disease Management and Epidemiology
- Plant Virus Research Studies
- Mosquito-borne diseases and control
- Hepatitis Viruses Studies and Epidemiology
- RNA modifications and cancer
- RNA regulation and disease
- Parvovirus B19 Infection Studies
- Genomics and Phylogenetic Studies
- Cytokine Signaling Pathways and Interactions
- Vector-Borne Animal Diseases
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ubiquitin and proteasome pathways
- thermodynamics and calorimetric analyses
- Advanced Mathematical Modeling in Engineering
- Vector-borne infectious diseases
- Microbial infections and disease research
Jiangsu University
2022-2025
Shanghai Jiao Tong University
2019-2024
Affiliated Hospital of Jiangsu University
2022-2024
Academic Degrees & Graduate Education
2024
Taizhou People's Hospital
2023
Nanjing Medical University
2023
Lishui University
2023
Nantong University
2023
Nanjing Forest Police College
2023
Huazhong Agricultural University
2014-2017
Porcine deltacoronavirus (PDCoV) is a newly detected porcine coronavirus causing serious vomiting and diarrhea in piglets, especially newborn piglets. There has been an outbreak of PDCoV worldwide since 2014, significant economic losses the pig industry. The interferon (IFN)-mediated antiviral response important component virus-host interactions plays essential role inhibiting virus infection. However, mechanism escaping immune surveillance unclear. In present study, we demonstrated that...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes 2019 disease (COVID-19), poses a significant threat to global public health security. Like other coronaviruses, SARS-CoV-2 has developed various strategies inhibit the production of interferon (IFN). Here, we have discovered that Nsp15 obviously reduces expression IFN-β and IFN-stimulated genes (ISG56, CXCL10), also inhibits IRF3 phosphorylation nuclear translocation by antagonizing RLR-mediated antiviral signaling...
Viral diseases caused by new outbreaks of viral infections pose a serious threat to human health. Wild brown rats (Rattus norvegicus), considered one the world's largest and most widely distributed rodents, are host various zoonotic pathogens. To further understand composition virus community in wild explore types potentially pathogenic viruses, metagenomics was conducted investigate blood, feces, tissues captured from Zhenjiang, China. Results indicated that different samples showed...
Cormorants, as protected wild animals by the State Forestry Administration of China, have a broad distribution across China. Previous studies shown that they can be infected with multiple viruses in Flaviviridae, Orthomyxoviridae, Paramyxoviridae, and Polyomaviridae families. There is limited knowledge about other cormorants may carry infect. In this study, we employed viral metagenomics to identify novel fecal samples collected from Xiamen City, Fujian Province, Two were identified,...
ABSTRACT Porcine deltacoronavirus (PDCoV) is a newly identified enteric coronavirus that causes serious diarrhea and vomiting in pigs, leading to substantial economic losses globally. Studying the molecular interactions between virus host proteins crucial for developing new anti-PDCoV strategies. Here, role mechanism of lactate dehydrogenase B (LDHB) PDCoV replication were investigated. LDHB suppresses dose-dependent manner, whereas knockdown via RNA interference enhances proliferation...
Diarrhea is the third leading cause of death in developing countries children under age five. About half a million die diarrhea every year, most which countries. Viruses are main pathogen diarrhea. In China, fecal virome with has been rarely studied. Using an unbiased viral metagenomics approach, we analyzed Many DNA or RNA viruses associated identified those samples were mainly from six families Adenoviridae, Astroviridae, Caliciviridae, Parvoviridae, Picornaviridae, and Reoviridae. Among...
Ticks are considered the second most common pathogen vectors transmitting a broad range of vital human and veterinary viruses. From 2017 to 2018, 640 ticks were collected in eight different provinces central western China. Six species detected, including H.longicornis, De.everestianus, Rh.microplus, Rh.turanicus, Rh.sanguineous, Hy.asiaticum. Sixty-four viral metagenomic libraries constructed on MiSeq Illumina platform, resulting 13.44 G (5.88 × 107) 250-bp-end reads, which 2,437,941...
Pigs are natural host to various zoonotic pathogens including viruses. In this study, we analyzed the viral communities in feces of 89 piglets with diarrhea under one month old which were collected from six farms Jiangsu Province Eastern China, using unbiased virus metagenomic method. A total libraries constructed, and 46937894 unique sequence reads generated by Illumina sequencing. Overall, family Picornaviridae accounted for majority putative mammalian Ten novel genomes different members...
Porcine reproductive and respiratory syndrome virus (PRRSV) is a single-stranded positive-sense RNA that can cause devastating failure tract lesions, which has led to serious damage the swine industry worldwide. Our previous studies have indicated Tongcheng (TC) pigs, Chinese local breed, stronger resistance or tolerance PRRSV infection than Large White (LW) pigs. This study aims investigate their host transcriptome differences in porcine alveolar macrophages (PAMs) at 7 days post challenge....
Aquaculture is important for food security and nutrition. The economy has recently been significantly threatened the risk of zoonoses increased by aquatic diseases, ongoing introduction new pathogens, particularly viruses, continues to represent a hazard. Yet, our knowledge diversity abundance fish viruses still limited. Here, we conducted metagenomic survey different species healthy fishes caught in Lhasa River, Tibet, China, sampled intestinal contents, gills, tissues. To be more precise,...
The swine industry plays an essential role in agricultural production China. Diseases, especially viral diseases, affect the development of pig and threaten human health. However, at present, tissue virome diseased pigs has rarely been studied. Using unbiased metagenomic approach, we investigated sick (respiratory symptoms, reproductive disorders, high fever, diarrhea, weight loss, acute death neurological symptoms) collected from farms Anhui, Jiangsu Sichuan Province, eukaryotic viruses...
The incidence of reporting caliciviruses in wild birds is less common than other animals, and the majority cases remain unclassified. A strain calicivirus was discovered this study feces cormorants collected at Xiamen Horticulture Expo Garden 2021 named Cormcali01. genome Cormcali01 8,561 bp length which contained characteristic motifs present caliciviruses. Furthermore, it demonstrated a significant deviation from all existing nucleotide sequences, exhibiting highest amino acid identity...
The diversity of birds in most parts the world is very high, and thus, they may carry different types highly differentiated unknown viruses. Thanks to advanced sequencing technologies, studies on bird-associated viruses have increased over past few years. In this study, a large-scale viral metagenomics survey was performed cloacal swabs 2,990 from nine provinces Chinese mainland. To detect undescribed RNA birds, more than 1,800 sequences sharing relatively low (<60%) amino acid sequence...
Abstract With the development of viral metagenomics and next-generation sequencing technology, more novel parvoviruses have been identified in recent years, including even entirely new lineages. The Parvoviridae family includes a different group viruses that can infect wide variety animals. In this study, systematic analysis was performed to identify “dark matter” (datasets cannot be easily attributed known viruses) explore their genetic diversity from wild birds’ cloacal swab samples. We...
Abstract The gut microbiome plays an essential role in the human health and dysbiosis has been implicated numerous diseases. Coxsackievirus B3 infects millions of humans yearly yet limited research explored dynamic alterations virome after infection. Here, we established mouse model infection collected fecal samples at several time points to investigate using viral metagenomic analysis. We found that mice was dominated by Caudovirales Microviridae , phylogenetic analyses showed both had high...
Enterovirus 71 (EV71) is a major virus that causes hand-foot - mouth disease. In cases of infants and young children, EV71 infection has been associated with severe neurological disease potentially fatal systemic complications. The sporadic outbreak worldwide increasingly prevalent in the Asia-Pacific region, where it become public health concern. No specific antiviral drugs are currently approved for treatment infection. purpose this study to comprehensively review research progress...
Mammals are potential hosts for many infectious diseases. However, studies on the viral communities of herbivorous mammals in Northwest Plateau limited. Here, we studied using virus metagenomic analysis to analyze and compare community composition seven animal species.By library construction next-generation sequencing, contigs singlets reads with similar sequences were classified into 24 families. Analyzed from perspective sampling areas, was relatively two areas Wuwei Jinchang, Gansu...
Abstract Porcine deltacoronavirus (PDCoV) is an enteropathogenic coronavirus that has been reported to use various strategies counter the host antiviral innate immune response. The cGAS-STING signalling pathway plays important role in immunity. However, it remains unclear whether PDCoV achieves evasion by regulating pathway. Here, we demonstrated nonstructural protein 2 (nsp2) encoded inhibits cGAS-STING-mediated type I and III interferon (IFN) responses via regulation of porcine STING...