A5101962495- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Studies
- Cancer Immunotherapy and Biomarkers
- Acute Ischemic Stroke Management
- Pancreatic and Hepatic Oncology Research
- Healthcare and Venom Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Acupuncture Treatment Research Studies
- Oral Health Pathology and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Gastric Cancer Management and Outcomes
- Metabolomics and Mass Spectrometry Studies
- Liver Disease and Transplantation
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Medical Research and Treatments
- Ferroptosis and cancer prognosis
- Esophageal Cancer Research and Treatment
- Urological Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Microbial Metabolic Engineering and Bioproduction
- Data-Driven Disease Surveillance
- Hepatitis B Virus Studies
Changchun University of Chinese Medicine
2020-2025
The Affiliated Hospital to Changchun University of Chinese Medicine
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Fourth Hospital of Hebei Medical University
2008-2024
Hebei Medical University
2008-2024
Peking Union Medical College Hospital
2015-2024
Academy of Medical Sciences
2023
China Rehabilitation Research Center
2017-2023
Capital Medical University
2017-2023
Liuzhou General Hospital
2009-2022
Background:The systemic immune-inflammation index (SII) has been reported to be associated with patient survival in various kinds of solid tumors.However, just few studies have focused on its prognostic value patients surgically resected esophageal squamous cell carcinoma (ESCC). Materials and Methods:This study was a single-institution, retrospective analysis 468 ESCC who underwent curative esophagectomy at the Department Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese...
Background Multiple studies have confirmed the significant role of cathepsins in development and progression digestive system tumors. However, further investigation is needed to determine causal relationships. Methods We conducted a two-sample bidirectional Mendelian randomization (MR) study using pooled data from genome-wide association (GWAS) assess associations between nine (cathepsin B, E, F, G, H, L2, O, S, Z) six types tumors, including hepatocellular carcinoma (HCC), pancreatic cancer...
Few clinical trials have evaluated the efficacy and safety of Tripterygium wilfordii Hook F (TwHF) compared with acitretin in psoriasis. We aimed to compare TwHF treatment moderate severe psoriasis vulgaris.Adults Psoriasis Area Severity Index (PASI) score ≥ 10 psoriasis-affected body surface area 10% were randomized into a (20 mg, 3 times day) or group (30 once day). The course lasted for 8 weeks. Patients assessed at baseline 2, 4, Laboratory tests performed baseline, week 8. data analyzed...
Spatial sampling is widely used in environmental and social research. In this paper we consider the situation where instead of a single global estimate mean an attribute for area, estimates are required each many geographically defined reporting units (such as counties or grid cells) because their means cannot be assumed to same figure. Not only may survey costs greatly increase if sample size has function number units, estimator error tends large population unit can estimated by using those...
This study aims to evaluate the ADL(activity of daily living) patients with acute cerebral infarction through BI scoring, in order observe its predictive value prognosis these patients.According inclusion and exclusion criteria, anterior circulation were included present study. Then, scoring was analyzed five grades, further investigate dose-response relationship between mortality risk infarction. The receiver operating characteristic (ROC) curves for BI-scored drawn, authenticity Barthel...
This study aims to investigate the predictive values of Chinese Stroke Scale (CSS) and National Institutes Health (NIHSS) in prognosis patients with acute cerebral infarction.A total 399 infarction were assessed using CSS NIHSS within 1 day after admission. Then, receiver operating characteristic (ROC) curves established, area under these 2 scoring systems was compared.The curve 0.796 0.794, respectively.CSS have good for infarction.
Aging and senescence can alter immune cell fitness influence the efficacy of lung cancer treatments, especially immunotherapy. However, correlations between cellular tumor microenvironment are still not clearly clarified value senescence-related genes in evaluating infiltration clinical outcomes adenocarcinoma (LUAD) need further investigated.We identified three clusters by NMF algorithm correlated with landscape LUAD patients. A prognostic scoring system was established using random...
Abstract Lung squamous cell carcinoma (LUSC) is the second most common lung cancer worldwide, leading to millions of deaths annually. Although immunotherapy has expanded therapeutic choices for LUSC and achieved considerable efficacy in a subset patients, many patients could not benefit, resistance was pervasive. Therefore, it significant investigate mechanisms patients’ poor response immunotherapies explore novel targets. Using multiple public datasets, we found that Kallikrein-8 (KLK8)...
The aim of the present study was to investigate effects cytomegalovirus (CMV) infection on prognosis inflammatory bowel disease (IBD). Various databases were searched using a combination keywords associated with CMV and IBD. Subsequent selection relevant studies in line strict inclusion exclusion criteria, meta‑analysis conducted Stata 12.0 software. A total 195 initially retrieved, including 28 Chinese 167 English. Following unsuitable studies, 7 cohort 374 IBD patients included...
Study Design. Retrospective study. Objective. To evaluate the outcomes and safety of endoscopic laminectomy for central lumbar canal spinal stenosis. Summary Background Data.. Spinal endoscopy is mostly used in treatment disc herniation, while stenosis rarely reported. Methods. From January 2016 to June 2017, 38 patients with were treated laminectomy. Clinical symptoms evaluated at 1, 3, 6, 12 months last follow-up after surgery. Functional assessed by using Japanese Orthopedic Association...
Background: Bladder cancer is a major urinary system cancer, and its mechanism of action regarding progression unclear. The goal this study was to examine the expression ADAM panel in clinical specimens bladder investigate role miR-3174/ADAM15 (a disintegrin metalloprotease 15) axis regulation cell proliferation. Methods: an gene (including ADAM8, 9, 10, 11, 12, 15, 17, 19, 22, 23, 28, 33), including 30 pairs tumor non-tumor specimens, examined by Ion AmpliSeq Targeted Sequencing. A microRNA...
There is no cost-effective, accurate, and non-invasive method for the detection of esophageal squamous cell carcinoma (ESCC) in clinical practice. We aimed to investigate diagnostic potential tumor-educated platelets ESCC. In this study, seventy-one ESCC patients eighty healthy individuals were enrolled divided into a training cohort (23 27 individuals) validation (48 53 individuals). Next-generation RNA sequencing was performed on isolated from peripheral blood all participants, support...
Background Previous observational studies have demonstrated a link between diabetes mellitus(DM) and primary biliary cholangitis (PBC). Nevertheless, since these relationships might be confused, whether there is any causal connection or in which direction it exists unclear. Our investigation aimed to identify the associations DM PBC. Methods We acquired genome-wide association study (GWAS) datasets for PBC, Type 1 diabetes(T1DM), 2 diabetes(T2DM) from published GWASs. Inverse...
This study aimed to establish machine learning models for preoperative prediction of the pathological types acute appendicitis.Based on histopathology, 136 patients with appendicitis were included and divided into three types: simple (SA, n=8), purulent (PA, n=104), gangrenous or perforated (GPA, n=24). Patients SA/PA PA/GPA training (70%) testing (30%) sets. Statistically significant features (P<0.05) pathology selected by univariate analysis. According clinical laboratory data, logistic...