A5100340278- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Machine Learning in Bioinformatics
- Microbial bioremediation and biosurfactants
- Selenium in Biological Systems
- Bioinformatics and Genomic Networks
- Microbial Community Ecology and Physiology
- Wastewater Treatment and Nitrogen Removal
- Chromium effects and bioremediation
- Microbial infections and disease research
- RNA and protein synthesis mechanisms
- Plant Pathogens and Fungal Diseases
- Antimicrobial Peptides and Activities
- Oral microbiology and periodontitis research
- Bacterial Genetics and Biotechnology
- Berberine and alkaloids research
- Enzyme-mediated dye degradation
- Antibiotic Use and Resistance
- Listeria monocytogenes in Food Safety
- Pharmacological Effects of Natural Compounds
- Silicon Effects in Agriculture
- Clostridium difficile and Clostridium perfringens research
Northwest University
2019-2025
Ministry of Education of the People's Republic of China
2019-2025
Hunan University of Traditional Chinese Medicine
2024-2025
Yangzhou University
2020-2021
Xinjiang Agricultural University
2021
China XD Group (China)
2020
Army Medical University
2020
Microbiology Institute of Shaanxi
2012-2019
Institute of Microbiology
2012-2019
Chinese Academy of Sciences
2012-2019
Introduction Vancomycin-resistant Enterococcus faecalis (VRE) poses a significant challenge in clinical settings due to its resistance multiple antibiotics. Phage therapy offers promising alternative address this crisis. However, critical gaps remain regarding optimal dosing, therapeutic design, and treatment timing for phage targeting VRE-induced bacteremia. Methods The biological genomic characteristics of novel lytic specific VRE were investigated. Its vitro bactericidal antibiofilm...
Summary A hallmark of bacterial biofilms is a self‐produced extracellular matrix exopolysaccharide, DNA ( eDNA ) and proteins that hold cells together in the community. However, interactions among components how contribute to formation remain unclear. Here, we show physical interaction between exopolysaccharide P sl , two key biofilm opportunistic pathogen seudomonas aeruginosa . The allows combine form web eDNA–P fibres, which resembles skeleton centre pellicles give bacteria structural...
ABSTRACT Biofilm formation is a complex process in which many factors are involved. Bacterial swarming motility and exopolysaccharides both contribute to biofilm formation, yet it unclear how bacteria coordinate exopolysaccharide production. Psl Pel two key matrix Pseudomonas aeruginosa . This opportunistic pathogen has three types of motility, swimming, twitching, swarming. In this study, we found that elevated and/or production reduced the P. but had little effect on swimming twitching....
Alzheimer's disease (AD), an age-associated neurodegenerative disorder, currently lacks effective clinical therapeutics. Traditional Chinese Medicine (TCM) holds promising potential in AD treatment, exemplified by Danggui Shaoyao San (DSS), a TCM formulation. The precise therapeutic mechanisms of DSS remain to be fully elucidated. This study aims uncover the efficacy and underlying AD, employing integrative approach encompassing gut microbiota metabolomic analyses.
Summary Exopolysaccharide is a critical biofilm matrix component, yet little known about how the synthesis of multiple exopolysaccharides regulated. Pseudomonas aeruginosa can produce several that include alginate, Psl and Pel. Here we demonstrated AlgC, key enzyme provides sugar precursors for alginate lipopolysaccharides (LPS) also required both Pel production. We showed forced‐synthesis in alginate‐producing mucoid bacteria reduced production but this was not due to transcription...
Bacterial motilities participate in biofilm development. However, it is unknown how/if bacterial motility affects formation of the matrix. Psl polysaccharide a key matrix component Pseudomonas aeruginosa. Here we report that type IV pili (T4P)-mediated migration leads to fibre-like Deletion T4P wild and flagella-deficient strains results loss Psl-fibres reduction biomass flow cell biofilms as well pellicles at air-liquid interface. Bacteria lacking T4P-driven twitching including those still...
The opportunistic pathogen Pseudomonas aeruginosa causes life-threatening, persistent infections in patients with cystic fibrosis (CF). Persistence is attributed to the ability of these bacteria form structured communities (biofilms). Biofilms rely on an extracellular polymeric substances matrix maintain structure. Psl exopolysaccharide a key component nonmucoid biofilms, yet role mucoid biofilms unknown. In this report, using variety mutants P. background, we found that deletion...
Abstract Fusarium verticillioides can be transmitted via seeds and cause systemic infection in maize ( Zea mays L.); its mycotoxin has harmful effects on animal human health. We combined QTL mapping recombinant inbred line (RIL) populations with a genome-wide association study (GWAS) of 217 diverse lines using 224,152 single nucleotide polymorphisms (SNPs) under controlled conditions to determine the genetic architecture F. seed rot (FSR) resistance. Our identified 8 quantitative trait loci...
Deoxynivalenol (DON) is one of the most prevalent food- and feed-associated mycotoxins. It frequently contaminates agricultural commodities poses serious threats to human animal health leads tremendous economic losses globally. Much attention has been paid using microorganisms detoxify DON. In this study, a Bacillus licheniformis strain named YB9 with strong ability DON was isolated characterized from moldy soil sample. could degrade more than 82.67% 1 mg/L within 48 h at 37 °C showed...
Pseudomonas aeruginosa, an important opportunistic pathogen, is capable of producing various virulence factors and forming biofilm that are regulated by quorum sensing (QS). It known targeting factor production formation instead exerting selective pressure on growth such as conventional antibiotics can reduce multidrug resistance in bacteria. Therefore, many quorum-sensing inhibitors (QSIs) have been developed to prevent or treat this bacterial infection. In study, wogonin, active ingredient...
Klebsiella pneumoniae, a major clinical pathogen known for causing severe infections, is attracting heightened attention due to its escalating antibiotic resistance. Phages are emerging as promising alternative antibiotics; however, their specificity particular hosts often restricts use. In this study, collection of 114 phages obtained and subjected analysis against 238 K. pneumoniae strains, revealing spectrum lytic behaviors. A correlation between putative tail protein clusters lysis...
Burn injuries often leave behind a "stasis zone", region of tissue critically important for determining both the severity injury and potential recovery. To understand intricate cellular epigenetic changes occurring within this critical zone, we utilized single-cell assay transposase-accessible chromatin sequencing (scATAC-seq) to profile over 31,500 cells from healthy rat skin stasis zone at nine different time points after burn injury. This comprehensive approach revealed 26 distinct cell...
Emerging contaminants refer to chemical substances that have not been widely regulated but possess the potential cause adverse effects on both environment and human health. Antibiotics, as emerging contaminants, pose significant threats ecosystems health due their widespread use persistence in environment. Levofloxacin, a broad-spectrum fluoroquinolone antibiotic, is commonly employed treatment of bacterial infections, has frequently detected environmental matrices freshwater systems. In...
The current fitting function of the basic magnetization curve does not provide exact fit necessary for simulation modeling electromechanical devices containing conductive materials, including polymers. Therefore, an odd polynomial based on spectral analysis results under sinusoidal excitation is proposed, and effect studied by comparative analysis. show that provides a better has simple expression, method obtaining new idea selection function.
When exposed to nutrient or nonnutrient germinants, individual Bacillus spores can return life through germination followed by outgrowth. Laser tweezers, Raman spectroscopy, and either differential interference contrast phase-contrast microscopy were used analyze the slow dipicolinic acid (DPA) leakage (normally ∼20% of spore DPA) from that takes place prior lag time, Tlag, when begin rapid release remaining DPA. Major conclusions this work with subtilis as follows: (i) DPA wild-type...
Bacteriophages (phages), or bacterial viruses, have recently received increasing attention, especially considering pan-drug-resistant bacteria, and studies on lytic bacteriophage proteins would help develop antibiotic candidates to treat these infections. We previously isolated sequenced a Streptomyces avermitilis bacteriophage, phiSASD1. This study aimed clone express ORF40 ORF19, predicted as endolysin (termed LytSD) holin HolSD), two crucial phage involved in host lysis. The yield of...