A5030029897- Allelopathy and phytotoxic interactions
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Pharmacological Effects of Natural Compounds
- Advanced Drug Delivery Systems
- Telomeres, Telomerase, and Senescence
- Biosensors and Analytical Detection
- Bacteriophages and microbial interactions
- Fish Biology and Ecology Studies
- SARS-CoV-2 detection and testing
- Plant-based Medicinal Research
- DNA Repair Mechanisms
- Genomics and Phylogenetic Studies
- Fish Ecology and Management Studies
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Herpesvirus Infections and Treatments
- Drug Transport and Resistance Mechanisms
- Antimicrobial Peptides and Activities
- Antibiotic Resistance in Bacteria
- Intracerebral and Subarachnoid Hemorrhage Research
- Extracellular vesicles in disease
- Ginkgo biloba and Cashew Applications
- Neuroendocrine Tumor Research Advances
Nanjing University of Chinese Medicine
2023-2025
Binzhou University
2025
Binzhou Medical University
2025
Zigong First People's Hospital
2023-2024
Affiliated Hospital of North Sichuan Medical College
2023-2024
Shenyang Agricultural University
2008-2024
North Sichuan Medical University
2024
Chinese PLA General Hospital
2022
Wuhan General Hospital of Guangzhou
2022
Ministry of Education of the People's Republic of China
2012-2021
The ends of chromosomes in mammals, called telomeres, are composed a 6 base pair repeat sequence, TTAGGG, which is added on by the enzyme telomerase. In combination with protein complex shelterin, these telomeric sequences form cap that protects chromosomes. Due to insufficient telomerase expression, telomeres shorten gradually each cell division human somatic cells, limits number times they can divide. extensive involved cancer progression therefore requires cells must acquire ability...
ABSTRACT Given the scale and rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, known as 2019-nCov) infection (COVID-19), ongoing global SARS-CoV-2 outbreak has become a huge public health issue. Rapid precise diagnostic methods are thus immediately needed for diagnosing COVID-19, providing timely treatment facilitating control. A one-step reverse transcription loop-mediated isothermal amplification (RT-LAMP) coupled with nanoparticles-based biosensor (NBS) assay...
Treatment for bone and joint tuberculosis (BJTB) is challenging due to its refractory recurrent nature. This study aimed develop a bioimplantable scaffold with osteoinductive antituberculosis characteristics treat BJTB. built on oxidized hyaluronic acid carboxymethyl chitosan hydrogel mixed hydroxyapatite as tissue engineered material. In order make the have biological activity of promoting repair, exosomes (Exoeng) were added innovatively. addition, drug-loaded liposomes equipped an...
The rise of antimicrobial resistance in ESKAPEE pathogens poses significant clinical challenges, especially polymicrobial infections. Bacteriophage-derived endolysins offer promise combating this crisis, but face practical hurdles. Our study focuses on engineering from a Klebsiella pneumoniae phage, fusing them with ApoE23 and COG133 peptides. We assessed the resulting chimeric proteins’ bactericidal activity against vitro . ApoE23-Kp84B (CHU-1) reduced over 3 log units CFU for A. baumannii...
Telomeres distinguish chromosome ends from double-strand breaks (DSBs) and prevent fusion. However, telomeres can also interfere with DNA repair, as shown by a deficiency in nonhomologous end joining (NHEJ) an increase large deletions at telomeric DSBs. The sensitivity of regions to DSBs is important the cellular response ionizing radiation oncogene-induced replication stress, either preventing cell division normal cells, or promoting instability cancer cells. We have previously proposed...
Context: Although nanocarriers provide promising potential for oral drug delivery, the delivery efficiency remains unsatisfactory and needs to be improved. Size is considered most important characteristic of nanoparticles related their absorption. Borneol has been proved have ability enhance penetration transport many drugs through various physical barriers.Objective: To investigate effect particle size coadministration borneol on pharmacokinetics bioavailability entrapped in different...
This study aimed to explore the morphology, loadability, and releasing profiles of CalliSpheres microspheres in delivering oxaliplatin.Varied amount (20, 40, 60, 80 mg oxaliplatin) concentration (1.25, 2.5, 5.0 mg/mL oxaliplatin were mixed with 3 sizes (50-150 μm, 100-300 300-500 μm) measure loadability. Of all, 20 oxaliplatin-loaded was prepared profiles, meanwhile, fetal bovine serum added determine effect on releasing. The morphology size distribution before after loading...
The caps on the ends of chromosomes, called telomeres, keep chromosomes from appearing as DNA double-strand breaks (DSBs) and prevent chromosome fusion. However, subtelomeric regions are sensitive to DSBs, which in normal cells is responsible for ionizing radiation-induced cell senescence protection against oncogene-induced replication stress, but promotes instability cancer that lack cycle checkpoints. We have previously reported I-SceI endonuclease-induced DSBs near telomeres a human line...
Context: Transporting drugs through the lymphatic system has attracted increasing attention. Lipid-based formulations have been proved to be an effective way improve systemic bioavailability of highly lipophilic by intestinal transport.Objective: The formulation polymer micelle was developed for probucol its transport.Materials and methods: Methoxy-polyethylenelglycol-distearyl phosphatidyl-ethanolamine (mPEG-DSPE) chosen develop micelles probucol. physicochemical properties were...
Marek's disease (MD) is a neoplastic that significantly affects the poultry industry. Long non-coding RNAs (lncRNAs) are crucial regulatory factors in various biological processes, including tumourigenesis. However, involvement of novel lncRNAs course MD virus (MDV) infection still underexplored. Here, we present first comprehensive characterization differentially expressed chicken spleen at different stages MDV infection. A series was identified each stage through screening. Notably, our...