A5082626083- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Intraperitoneal and Appendiceal Malignancies
- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- Endometriosis Research and Treatment
- Protein Kinase Regulation and GTPase Signaling
- RNA modifications and cancer
- Hippo pathway signaling and YAP/TAZ
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Cancer-related molecular mechanisms research
- MRI in cancer diagnosis
- Galectins and Cancer Biology
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Alkaline Phosphatase Research Studies
- Glycosylation and Glycoproteins Research
- RNA Research and Splicing
- Microtubule and mitosis dynamics
- Signaling Pathways in Disease
- Cancer Risks and Factors
- Mechanisms of cancer metastasis
- Heat shock proteins research
Chongqing Medical University
2014-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2014-2024
Hokkaido University
2006-2008
Chongqing University
2003
Abstract This study investigated the role of glutamine-fructose-6-phosphate transaminase 2 (GFPT2) in response epithelial ovarian cancer cells to paclitaxel, a standard chemotherapy drug. We analyzed GFPT2 expression across various EOC cell lines, including SKOV3, HEY, ES-2, A2780, and OVCR3. In HEY we performed knockdown, while A2780 were engineered for overexpression. Following these manipulations, assessed cellular responses paclitaxel treatment. Results demonstrated correlation between...
Serous ovarian cancer (SOC) accounts for >50% of all epithelial cancers. However, patients with SOC present various degrees response to platinum‑based chemotherapy and, thus, their survival may differ. The study aimed identify the candidate genes involved in carcinogenesis and drug resistance by analyzing microarray datasets GDS1381 GDS3592. GDS3592 were downloaded from Gene Expression Omnibus database (https://www.ncbi.nlm.nih.gov/gds/). A total 219 differentially expressed (DEGs)...
Abstract Objectives To develop a multiparameter magnetic resonance imaging (MRI)-based radiomics approach that can accurately predict the tumor cell proliferation status of serous ovarian carcinoma (SOC). Materials and methods A total 134 patients with SOC who met inclusion exclusion criteria were retrospectively screened from institution A, spanning January 2016 to March 2022. Additionally, an external validation set comprising 42 B was also included. The region interest determined by...
Type I epithelial ovarian cancer (EOC) is primarily resistant to platinum-based chemotherapies and needs novel therapeutics. Given the aberrant Wnt activation in type EOC involvement of Dapper1 Antagonist Catenin-1 (DACT1) signalling, role DACT1 tumourigenesis was evaluated. Firstly, all tested cell lines primary tissues, especially EOC, were observed have significantly lower expression than normal controls. Next, 3AO cells, which arise from a patient with mucinous express low endogenous...
Small GTPases, particularly the Rho family, are key regulators of cell motility and migration. Dock180 was well known for main target signal adaptor protein Crk acted as a guanine-nucleotide exchange factor small GTPase Rac1. In present study, found to combine primarily with CrkI other than CrkII, its association Elmo1 also demonstrated in ovarian cancer SKOV3. To evaluate role human cell, we performed RNAi-mediated knockdown SKOV3 cells using interfering RNA expression vector. cells, that...
Objective Engulfment and cell motility 1 (Elmo1) has been reported to cooperate with dedicator of cytokinesis (Dock180) be linked the invasive phenotype cancer cells through activating small G-protein Rac. We aimed study role Elmo1 in malignant migration ovarian cancer. Methods expression was evaluated specimens from 93 patients serous (SOC) by immunohistochemical staining. Next, Elmo1-RNAi were established validated interference RNAs. Cell proliferation observed compared Dock180-RNAi cells....
Abstract Adaptor protein Crk and CrkL were thought to be closely related because both consist of one SH2 two SH3 domains share 60% homology with the highest identity within their functional domains. Their functions most presumed in part, if not all, redundant. And suggested implicated carcinogenesis. In this study, presented much higher expression ovarian cancer tissues than those normal benign tissues. However, contrast CrkL, high displayed close association advanced stages high‐grade...
Epithelial ovarian cancer is the most lethal gynecological malignant tumor. Although debulking surgery, chemotherapy, and PARP inhibitors have greatly improved survival, prognosis for patients with advanced EOC without HRD still poor. LLGL2, as a cell polarity factor, involved in maintaining asymmetric division. In study of zebrafish development, LLGL2 regulated proliferation migration epidermal cells formation cortical F-actin. However, role has not been described. Our found, through...
Purpose: Wolf–Hirschhorn syndrome candidate 1 (WHSC1) is an epigenetic modifier, considered to play a driving role in oncogenesis. However, very little known about the roles of WHSC1 and its prognostic impacts cervical cancer. This study aimed investigate prognosis cancer explore effect on proliferation, migration, invasion cells angiogenesis human umbilical vein endothelial (HUVECs). Methods: We evaluated expression levels samples relevant cell lines by immunohistochemistry, real-time...
Background:Integrin b1 subunit and its downstream molecule, focal adhesion kinase (FAK), have been demonstrated to be indispensible the promotion of cell proliferation survival anti-apoptosis in cardiomyocytes via activation their pro-survival signaling AKT.As a component integrin pathway, Dock180 (dedicator cytokinesis 1) protein is also thought involved H9C2 cardiomyocytes.Material/Methods: Rat-derived were transfected with pCXN2-flag-hDock180, human overexpression eukaryotic recombinant...
To observe the feasibility and efficacy of Pseudomonas aeruginosa-mannose sensitive hemagglutinin (PA-MSHA) in refractory lymphatic leakage following lymphadenectomy among patients with gynecological cancers.Ten cases post-operative massive were collected, which failed to respond conservative treatment. Topical PA-MSHA injection a single dose (2mL) was performed through drainage tube or transvaginal catheter into pelvic peritoneal cavity. Drainage volumes side effects recorded.The incidence...
Objective: To determine the predictive value of cytokeratin 19 (CK19) for evaluating safety ovarian preservation in patients with endometrial cancer (EC). Methods: Five hundred and seventeen EC hospitalized from November 2010 to June 2016 were reviewed retrospectively. Pre-operative tumor biomarkers including CA125, HE4, CK19, CA19-9 obtained. Predictive associated metastasis selected using univariate multivariate Logistic regression. The cut-off values determined by receiver operating...
Abstract Integrin β1 subunit and its downstream molecules, such as integrin‐linked kinase focal adhesion kinase, are imperative for promotion of cell proliferation, survival anti‐apoptosis in cardiomyocytes by activation their pro‐survival signalling the phosphorylated extracellular signal‐regulated kinase1/2 (p‐ERK1/2). As a component integrin pathway, C3G (Crk‐SH3 domain guanine nucleotide exchange factor) protein may be involved proliferation H9C2 cardiomyocytes. Rat ‐ derived were...