In this study, we explored the effectiveness and safety of immune checkpoint inhibitor camrelizumab in combination with chemotherapy for treatment cervical cancer by investigating adverse effects changes tumor volume, activity, biochemical indices. retrospective analysis, experimental group was administered intravenous conjunction a TP regimen (consisting paclitaxel analog platinum analog), while control given only regimen. The solid tumors, SCC-Ag values, apparent diffusion coefficient...

Type I epithelial ovarian cancer (EOC) is primarily resistant to platinum-based chemotherapies and needs novel therapeutics. Given the aberrant Wnt activation in type EOC involvement of Dapper1 Antagonist Catenin-1 (DACT1) signalling, role DACT1 tumourigenesis was evaluated. Firstly, all tested cell lines primary tissues, especially EOC, were observed have significantly lower expression than normal controls. Next, 3AO cells, which arise from a patient with mucinous express low endogenous...

Abstract There is no recognized serum biomarker to predict the recurrence of endometrial carcinoma (EC). We aimed explore human epididymis protein 4 (HE4) and cancer antigen 125 (CA125) as biomarkers monitor type II EC. 191 patients diagnosed with EC were involved for this retrospective study. Comparing recurrent non-recurrent patients, HE4 levels resulted a statistically significant difference at primary diagnosis recurrence, respectively (P = 0.002 P < 0.001), while CA125 0.001)...

Abstract Objective Ascites is a tumor microenvironment, ascites and massive ascites‐induce compression could promote the progression of epithelial ovarian cancer (EOC); however, impact volume on clinical outcomes has not been studied extensively. We aimed to investigate association between especially platinum resistance in EOC. Methods retrospectively evaluated total 546 EOC patients with respect amount ascites, clinicopathologic factors, survival. Using threshold 1500 ml classify into...

Spillage of cyst contents during surgical operation is the major cause recurrence after hydatid surgery. Instillation a scolicidal agent into hepatic most commonly employed measure to prevent this complication. SB202190 pyridinyl imidazole derivative and known be specific inhibitor p38 MAPK. In present study, effect was investigated. Freshly isolated Echinococcus granulosus protoscolices were subjected treatment (10, 20, 40, 80 µM), effects on parasite viability monitored by trypan blue...

In this study, 345 patients with endometrial carcinoma (EC) were selected to investigate the correlation between ER/PR status and EC disease-free survival (DFS) rate.The intensity proportion of tumor cell expression estrogen receptors progesterone (ER/PR) postoperative specimens in ECs independently assessed semi-quantitatively by two pathologists using immunohistochemistry, summed score ranged from 0 8 points was worked out adding based on breast cancer hormone receptor immunohistochemical...

Leiomyosarcoma (LMS) is a rare and extremely aggressive malignancy that derived from or shows evidence of differentiation toward smooth muscle. If LMS occurs in the female reproductive system, preoperative diagnosis can be difficult, as easily mistaken for uterine leiomyoma, especially degenerated fibroid (DUF). Thus, we assessed diagnostic value serum concentrations cancer antigen 125 (CA125), lactate dehydrogenase (LDH) human epididymis protein 4 (HE4) differentiating DUF.We enrolled...

Endometrial cancer (EC) is the most common gynecologic cancer. The overall survival remains unsatisfying due to lack of effective treatment screening approaches. Immunotherapy as a promising therapy has been applied for EC treatment, but still fails in many cases. Therefore, there strong need optimize approach clinical treatment. In this study, we employed co-expression network (GCN) analysis mine immune-related GCN modules and key genes further constructed an risk score model (IRSM). IRSM...

Objective The Ki-67 index is used to evaluate cell proliferation activity, which related tumor progression, metastasis, and prognosis. We aimed explore the prognostic value of in endometrial stromal sarcoma optimal cut-off for predicting recurrent sarcoma. Methods A total 82 patients with who were treated our hospital collected. Clinicopathological data these retrospectively analyzed. was detected by immunohistochemical method. Receiver operating characteristic curve Youden performed...

Endometrial carcinoma is a common malignant tumor in female reproductive system. At present, there no effective and economic prognostic index. This study aimed to investigate the effect of serum ferritin levels on prognosis endometrial carcinoma. Data 367 patients who diagnosed with at First Affiliated Hospital Chongqing Medical University between January 2012 August 2018 was retrospectively analyzed. The prediction accuracy evaluated by receiver operating characteristics curves Youden's J...

To explore the effects of curcumin on invasion and metastasis in human cervical cancer cells Caski. Caski were treated with 10, 25, 50μmol/L for 24, 48, 72 h. Proliferation was measured MTT assay. When h, expressions MMP-2, MT1-MMP NF-κB detected by Western-blot, evaluated transwell chamber. After being 10μmol/L, 25μmol/L, 48 proliferation inhibited a dose-and time-dependent manner. The expression decreased when treatment curcumin, assay, number group to migrate filter coated Matrigel...

Abstract To describe the perinatal outcomes of twin pregnancies with preterm premature rupture membranes (PPROM) before 34 weeks’ gestation and identify factors associated discharge without severe or moderate-severe neonatal morbidity. This study was conducted as a retrospective analysis PPROM occurring at 24 0/7 to 33 6/7 gestation. Perinatal were assessed by gestational age (GA) compared between non twins. Factors morbidity identified using logistic regression analysis. Of 180 (360...

To evaluate the role of apparent diffusion coefficient (ADC) value in individualized management stage I endometrial carcinoma (EC).A retrospective analysis was performed on 180 patients with EC who underwent 1.5-T magnetic resonance imaging. The mean ADC (mADC), minimum (minADC), and maximum (maxADC) values each group were measured compared. We analyzed relationship between prognosis by Kaplan-Meier method Cox proportional hazards analysis.Patients lower more likely to be characterized...

Three-dimensional (3D) reconstructed models have been shown to improve visualization in complex female pelvic tumors. Cinematic rendering (CR) is a 3D imaging technique for computed tomography (CT) images, which creates more realistic images with the ability enhance of anatomical features diagnosis. This study was set up compare two types and validate use techniques diagnosis

Epithelial ovarian cancer (EOC) is the most lethal gynaecological malignancy, and there a deficiency of information in literature on early recognition short-term survivor (STS). This study aimed to identify clinicopathological factors associated with STS late-stage EOC establish predictive model STS.Selected patients International Federation Gynecology Obstetrics (FIGO) stage III or IV were included study, retrospective analysis was performed. The characteristics who survived not more than 2...

Overexpression of Krüppel like factor 2 (Klf2) or Klf7 inhibits adipocyte formation. However, it remains unclear whether Klf2 regulates klf7 expression in adipose tissue. In this study, oil red O staining and Western blotting were employed to study the effect overexpression on differentiation chicken preadipocytes. The results showed that inhibited preadipocytes induced by oleate pparγ, while promoted Spearman correlation analysis was used between data klf2 tissue both human chicken. there a...

To evaluate the role of serum human epididymis secretory protein 4 (HE4) and carbohydrate antigen 125 (CA125) levels for predicting monitoring recurrence endometrial endometrioid carcinoma (EEC) assessing preoperative risk stratification in EEC patients. A total 434 patients were selected this retrospective study between May 2011 August 2018. Serum HE4 CA125 analyzed before initial treatment, at first postoperative follow-up, or last follow-up. Patients stratified according to European...

Background There is a lack of literature on short latency period (SLP) in twin pregnancies with preterm premature rupture membranes (PPROM). Thus, the aim this study was to identify clinical factors and perinatal outcomes associated SLP PPROM establish predictive model SLP. Methods Twin between 24 0/7 33 6/7 weeks were included retrospective analysis performed. Patients divided into two groups based after PPROM: Group 1 ≤24 h (defined as SLP) 2 >24 long period, LLP), compared groups....

Background To date, there are no consensus methods to evaluate the high-risk factors and prognosis for managing personalized treatment schedule of patients with endometrial carcinoma (EC) before treatment. Apparent diffusion coefficient (ADC) is regarded as a kind technique assess heterogeneity malignant tumor. Purpose explore role ADC value in assessing EC. Material Methods A retrospective analysis was made on 185 EC who underwent 1.5-T magnetic resonance imaging (MRI). Mean (mADC), minimum...

Abstract Objective: To describe the perinatal outcomes of twin pregnancies with preterm premature rupture membranes (PPROM) before 34 weeks’ gestation and identify factors associated discharge without severe or moderate-severe neonatal morbidity. Methods: This study was conducted as a retrospective analysis PPROM occurring at 24 0/7 to 33 6/7 gestation. Perinatal were assessed by gestational age (GA) PPROM. Factors morbidity identified using logistic regression analysis. Results: Of 180 (360...