A5100849666- Enzyme Catalysis and Immobilization
- Nanoparticle-Based Drug Delivery
- Electrochemical sensors and biosensors
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Characterization and Applications of Magnetic Nanoparticles
- Enzyme Production and Characterization
- Enzyme-mediated dye degradation
- Photodynamic Therapy Research Studies
- Immunotherapy and Immune Responses
- Polymer Surface Interaction Studies
- Advanced Nanomaterials in Catalysis
- Amino Acid Enzymes and Metabolism
- Plant-derived Lignans Synthesis and Bioactivity
- X-ray Diffraction in Crystallography
- Protein Hydrolysis and Bioactive Peptides
- Metabolism and Genetic Disorders
- Microbial Metabolic Engineering and Bioproduction
- Crystallization and Solubility Studies
- Hydrogels: synthesis, properties, applications
- Advanced Photocatalysis Techniques
- Pickering emulsions and particle stabilization
- Quantum Dots Synthesis And Properties
- Skin Protection and Aging
Nanjing Institute of Technology
2025
Sichuan University
2012-2024
Nanjing University of Science and Technology
2015-2024
Guiyang Medical University
2022-2024
Affiliated Hospital of Guizhou Medical University
2022-2024
West China Hospital of Sichuan University
2024
Shenyang Pharmaceutical University
2024
State Key Laboratory of Biotherapy
2015-2022
Zunyi Medical University
2016-2020
Nanjing Agricultural University
2011-2013
Abstract The combination of chemotherapy and photodynamic therapy (PDT) has promising potential in the synergistic treatment cancer. However, are impeded by uncontrolled chemotherapeutics release behavior, targeting deficiencies, hypoxia‐associated poor PDT efficacy solid tumors. Here, a platinum nanozyme (PtNP) loaded reactive oxygen species (ROS)‐responsive prodrug nanoparticle (CPT‐TK‐HPPH/Pt NP) is created to overcome these limitations. ROS‐responsive consists thioketal bond linked with...
The prevalence of skin cancer is rising along with the rapid population aging in recent years. Traditional therapies, such as surgical treatment, radiotherapy, chemotherapy, photodynamic therapy, and immunotherapy, may accompany serious side effects, limiting their clinical benefits. According to biological characteristics cancer, we have already established two kinds synergetic systems photothermal therapy (microneedle) containing gold nanorods (GNR). Although microneedle system exhibited...
Abstract Minimizing drug leakage in systemic circulation, synchronizing the vivo fate of multiple drugs, and precisely controlling tumor locoregional release, remain challenging for nanomedicine‐based cancer therapy. Here, a reactive oxygen species (ROS)‐responsive camptothecin (CPT) prodrug delivery system (MPEG‐(TK‐CPT)‐PPa) is developed, which CPT photosensitizer pyropheophorbide‐a (PPa) are concurrently conjugated to same poly(ethylene glycol) methyl ether (MPEG) via ROS‐responsive...
Improving the efficacy of melanoma treatment remains an important global challenge. Here, we combined chemotherapy with protein tyrosine phosphatase nonreceptor type 2(Ptpn2) based immunotherapy in effort to address this Short-hairpin RNA (shRNA) targeting Ptpn2 was coencapsulated doxorubicin (DOX) cell membrane M1 macrophages (M1HD@RPR). The prepared nanoparticles (NPs) were effectively phagocytosed by B16F10 cells and macrophages, but not M0 macrophages. Hence, NP evasion from...
Immune checkpoint inhibitors have achieved unprecedented success in cancer immunotherapy. However, the overall response rate to immune inhibitor therapy for many cancers is only between 20 and 40%, even less colorectal (CRC) patients. Thus, there an urgent need develop efficient immunotherapeutic strategy CRC. Here, we developed a novel CRC combination consisting of multiple receptor tyrosine kinase (Foretinib) anti-PD-1 antibody. The significantly inhibited tumor growth mice, led improved...
Flexible magnesium (Mg)-air batteries provide an ideal platform for developing efficient energy-storage devices toward wearable electronics and bio-integrated power sources. However, high-capacity bio-adaptable Mg-air still face the challenges in low discharge potential inefficient oxygen electrodes, with poor kinetics property reduction reaction (ORR). Herein, spinel nickel cobalt oxides (NiCo
Photodynamic therapy (PDT) brings new hope for the treatment of breast cancer due to few side effects and highly effective cell killing; however, low bioavailability traditional photosensitizers (PSs) their dependence on oxygen severely limits application. Aggregation-induced emission (AIE) PSs can dramatically facilitate photosensitization effect, which have positive impacts tumor PDT. To-date, most AIE lack targeting capability possess poor delivery, resulting in use large quantities that...
Abstract A novel method for the preparation of monodisperse porous silica microspheres with controllable morphology and structure is reported. The starting polymer were first functionalized ethylenediamine (EDA) to generate amino groups. Subsequently, nanoparticles deposited in microsphere form polymer/silica hybrid via a modified sol‐gel process presence tetra‐ n ‐butylammonium bromide (TBAB) or tetramethyl ammonium hydroxide (TMAH). Upon calcination microspheres, obtained. morphology,...