A5005463721- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Topic Modeling
- Nanoplatforms for cancer theranostics
- Natural Language Processing Techniques
- Analytical Chemistry and Sensors
- Advanced Text Analysis Techniques
- Photoreceptor and optogenetics research
- Spectroscopy Techniques in Biomedical and Chemical Research
- ECG Monitoring and Analysis
- EEG and Brain-Computer Interfaces
- Porphyrin and Phthalocyanine Chemistry
- Expert finding and Q&A systems
- Non-Invasive Vital Sign Monitoring
- Supramolecular Self-Assembly in Materials
- Education and Learning Interventions
- Electrochemical sensors and biosensors
- Advanced biosensing and bioanalysis techniques
- Advanced Combustion Engine Technologies
- Photochemistry and Electron Transfer Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Glaucoma and retinal disorders
- Speech and dialogue systems
- Electron Spin Resonance Studies
- Nanocluster Synthesis and Applications
Korea Institute of Science and Technology
2015-2025
Dong-A University
2024
Korea Institute of Toxicology
2018-2022
Seoul National University
2003-2021
LG (South Korea)
2021
Government of the Republic of Korea
2021
University at Buffalo, State University of New York
2015-2020
Korea Advanced Institute of Science and Technology
2019
Zero to Three
2018
Electronics and Telecommunications Research Institute
2006-2017
Abstract Molecular aggregates are receiving tremendous attention, demonstrating immense potential for biomedical applications in vitro and vivo. For instance, the molecular of conventional fluorophores influence electronic excitation states aggregates, causing characteristic photophysical property changes. A fundamental understanding this classical relationship between aggregate structures photophysics has allowed innovative biological applications. The chemical characteristics drug...
This study proposes the use of flexible capacitive electrodes for reducing motion artifacts in a wearable electrocardiogram (ECG) device. The have conductive foam on their surface, shield, an optimal input bias resistor, and guarding feedback. are integrated chest belt, acquired signals transmitted wirelessly ambulatory heart rate monitoring. We experimentally validated electrode performance with subjects standing walking treadmill at speeds up to 7 km/h. results confirmed highly accurate...
Amyotrophic lateral sclerosis (ALS) patients whose voluntary muscles are paralyzed commonly communicate with the outside world using eye movement. There have been many efforts to support this method of communication by tracking or detecting An electrooculogram (EOG), an electro-physiological signal, is generated movements and can be measured electrodes placed around eye. In study, we proposed a new practical electrode position on forehead measure EOG signals, developed wearable measurement...
Dynamic manipulation of supramolecular self-assembled structures is achieved irreversibly or under non-physiological conditions, thereby limiting their biomedical, environmental, and catalysis applicability. In this study, microgels composed azobenzene derivatives stacked via π-cation π-π interactions are developed that electrostatically stabilized with Arg-Gly-Asp (RGD)-bearing anionic polymers. Lateral swelling RGD-bearing occurs cis-azobenzene formation mediated by...
Pyrrolic viscosity sensors exhibit one order of magnitude higher fluorescence contrast compared to that the conventional phenolic analogues due viscosity-sensitive rotation rotational pyrrole group.
Abstract Native tissues exhibit hierarchical structures of anisotropically arranged extracellular matrix that dynamically regulate stem cells and tissue function. However, neither multiscale nano‐anisotropy nor dynamic anisotropy control have been reported. In this study, spherical or rod‐shaped gold small‐nanomaterials (at integrin receptor‐scale; tens nanometers) are coupled to the surface magnetic large‐nanomaterials focal adhesion complex‐scale; hundreds nanometers), with both showing...
Abstract Raman microspectroscopy provides for high-resolution non-invasive molecular analysis of biological samples and has a breakthrough potential dissection cellular composition at single organelle level. However, the can be fully realized only when novel types probes distinguishable in spectroscopy modality are developed labeling specific domains to guide spectrochemical spatial imaging. Here we report on design next generation probe, based BlackBerry Quencher 650 compound, which...
In this study, we have demonstrated the reconstruction of encrypted information by employing photoluminescence spectra and lifetimes a phosphorescent Ir(III) complex (IrHBT). IrHBT was constructed on basis heteroleptic structure comprising fluorescent N^O ancillary ligand. From viewpoint security, transformation between states can be encoded with chemical/photoirradiation methods. Thin polymer films (poly(methylmethacrylate), PMMA) doped display long-lived emission typical phosphorescence...
Extracellular matrix (ECM) undergoes dynamic inflation that dynamically changes ligand nanospacing but has not been explored. Here we utilize ECM-mimicking photocontrolled supramolecular ligand-tunable Azo
Abstract A series of fluorescent molecular rotors obtained by introducing two rotational groups (“rotators”), which exhibit different and electron‐donating abilities, are discussed. Whereas the control rotor, PH, includes a single rotator (the widely used phenyl group), PO consist rotators (a group an alkoxy simultaneous strongly easy abilities. Compared with rotor exhibited one order magnitude higher quantum yield (fluorescence intensity) simultaneously significantly fluorescence contrast....
Abstract Less toxic and highly fluorescent nanoparticles are in high demand to image biological events early‐stage disease. A strategy fabricate organic by laser ablation of aggregation‐induced enhanced emission (AIE) luminophores, which free any solvent surfactant, is presented. As these dyes provide no concentration quenching, the increased number photoluminescent molecules a nanoparticle produces bright fluorescence even with their small size (<2 nm), making them suitable for...
Doubly resonant infrared-visible sum-frequency generation (DR-IVSFG) spectroscopy, encompassing coupled vibrational and electronic transitions, provides a powerful method to gain deep understanding of nuclear motion in photoresponsive surface adsorbates interfaces. Here, we use DR-IVSFG elucidate the role vibronic coupling surface-confined donor-acceptor substituted azobenzene. Our study reveals some unique features that have not been previously reported. In particular, resulted prominent...
Abstract The drug solubility and its release profiles of an anticancer from injectable thermosensitive poly(organophosphazene) hydrogel bearing hydrophobic L ‐isoleucine ethyl ester hydrophilic α‐amino‐ω‐methoxy‐poly(ethylene glycol) with without hydrolysis‐sensitive glycyl lactate or functional glycine have been investigated. 5‐Fluorouracil (5‐FU) was used as a model drug. aqueous solutions 5‐FU incorporated poly(organophosphazenes) were fluid state at room temperature formed transparent...
A nanoreactor approach based on the amphiphilic assembly of various molecules offers a chance to finely engineer internal reaction medium enable highly selective and sensitive detection H2S in biological media, being useful for microscopic imaging cellular processes vitro diagnostics with blood samples.
Microbubbles are clinically used as an imaging agent for contrast-enhanced ultrasound image. Beyond the preformed microbubbles, nanoscale gas-generating chemical systems that capable of stimulus-responsive inflation to microbubbles have recently been employed a new echogenic strategy molecular imaging. Here, we report peroxamide-based contrast H2O2-responsive gas (CO2)-generating system diagnostic inflammatory diseases. A hydrolytic degradation-resistant peroxamide nanogel was constructed by...
Abstract As large molecular tertiary structures, some proteins can act as small robots that find, bind, and chaperone target protein clients, showing the potential to serve smart building blocks in self‐assembly fields. Instead of using such intrinsic functions, most methodologies for aim de novo‐designed structures with accurate geometric assemblies, which limit procedural flexibility. Here, a strategy enabling polymorphic clustering quaternary proteins, exhibiting simplicity flexibility...
Abstract Summary: After synthesizing both hard poly(organophosphazenes), which acted as strong hydrogels at a temperature below 37 °C, and soft displayed the opposite properties, we blended polymers. When these polymers were an appropriate ratio, aqueous solution changed into transparent hydrogel with improved mechanical properties of °C. According to DSC IR measurements, two homogeneously exhibited behavior characteristic completely different copolymer. An poly(organophosphazene) room...