A5101783099- Microbial Natural Products and Biosynthesis
- Carbohydrate Chemistry and Synthesis
- Enzyme Structure and Function
- Natural product bioactivities and synthesis
- Biochemical and Molecular Research
- Synthetic Organic Chemistry Methods
- RNA and protein synthesis mechanisms
- Histone Deacetylase Inhibitors Research
- Clusterin in disease pathology
- Phytochemical compounds biological activities
- Plant Gene Expression Analysis
- Plant biochemistry and biosynthesis
- Protein Structure and Dynamics
- Metal-Catalyzed Oxygenation Mechanisms
- Glycosylation and Glycoproteins Research
- Phytochemistry and Biological Activities
- Supercapacitor Materials and Fabrication
- Neuroscience and Neuropharmacology Research
- Cancer-related gene regulation
- Fungal Biology and Applications
- Photoreceptor and optogenetics research
- Redox biology and oxidative stress
- Cellular transport and secretion
- Ion channel regulation and function
- Ginger and Zingiberaceae research
Institute for Basic Science
2021-2024
Korea University
2011-2024
Kyungpook National University
2022
Chungnam National University
2021
Inha University
2020
Incheon National University
2018
Ewha Womans University
2007-2017
Ewha Womans University Medical Center
2008-2014
Korea Research Institute of Bioscience and Biotechnology
2013
Kangwon National University
2012
Summary Nickel serves as a cofactor for various microbial enzymes including superoxide dismutase (SOD) found in Streptomyces spp. In coelicolor , nickel represses and induces production of Fe‐containing Ni‐containing SODs, respectively, primarily at the transcriptional level. We identified nickel‐responsive regulator (Nur), Fur ( f erric‐ u ptake r egulator) homologue, which binds to promoter region sodF gene encoding FeSOD presence nickel. Disruption nur caused constitutive expression no...
Abstract Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate hyperglycemia, which causes endothelial dysfunction and peripheral neuropathy, ultimately leading to multiple complications. One prevalent complication diabetic erectile (ED), more severe resistant treatment than nondiabetic ED. The serum glycoprotein leucine-rich ɑ-2-glycoprotein 1 (LRG1) modulator of TGF-β-mediated angiogenesis has been proposed as biomarker for variety diseases, including DM....
Abstract Impaired ion channels regulating Golgi pH lead to structural alterations in the apparatus, such as fragmentation, which is found, along with cognitive impairment, Alzheimer’s disease. However, causal relationship between altered structure and impairment remains elusive due lack of understanding apparatus brain cells. Here, we identify that a transmembrane protein TMEM87A, renamed Golgi-pH-regulating cation channel (GolpHCat), expressed astrocytes neurons contributes...
Doxorubicin, one of the most widely used anticancer drugs, is composed a tetracyclic polyketide aglycone and l-daunosamine as deoxysugar moiety, which acts an important determinant its biological activity. This exemplified by fewer side effects semisynthetic epirubicin (4'-epi-doxorubicin). An efficient combinatorial biosynthetic system that can convert exogenous ε-rhodomycinone into diverse glycosylated derivatives doxorubicin or intermediates, rhodomycin D daunorubicin, was developed...
Abstract (−)‐Syringaresinol and tricin, isolated from the AcOEt‐soluble extract of whole plants Sasa borealis (Gramineae), showed inhibitory effects on P‐glycoprotein in adriamycin‐resistant human breast cancer cells, MCF‐7/ADR.
GTP and branched-chain amino acids (BCAAs) are metabolic sensors that indispensable for the determination of status cells. However, their molecular sensing mechanism remains unclear. CodY is a unique global transcription regulator recognizes BCAAs as specific signals affects expression more than 100 genes associated with metabolism. Herein, we report first crystal structures full-length complex molecules describe functional states. We observed two different oligomeric states CodY: dimeric...
Abstract SLITRK2 is a single-pass transmembrane protein expressed at postsynaptic neurons that regulates neurite outgrowth and excitatory synapse maintenance. In the present study, we report on rare variants (one nonsense six missense variants) in X chromosome identified by exome sequencing individuals with neurodevelopmental disorders. Functional studies showed some displayed impaired membrane transport synapse-promoting effects. Strikingly, these variations abolished ability of wild-type...
On the basis of dehydration reaction carbohydrate molecules assisted by sulfuric acid, we have invented a novel soft chemical route to carbon coating metal oxides. As representative, this technique has been applied spinel LiMn2O4 electrode material for lithium secondary batteries. Electron microscopy, elemental analysis, and N2 adsorption−desorption isotherm measurements clearly demonstrate that porous nanolayer with thickness ∼10−25 nm is successfully coated sucrose-adsorbed manganese oxide...
Abstract Coicis semen (=the hulled seed of Coix lacryma‐jobi L. var. ma‐yuen ( Rom.Caill. ) Stapf ; Gramineae), commonly known as adlay and Job's tears, is widely used in traditional medicine a nutritious food. Bioassay‐guided fractionation the AcOEt fraction unhulled adlays, using measurement nitric oxide (NO) production on lipopolysaccharide (LPS)‐stimulated RAW 264.7 macrophage cells, led to isolation identification two new stereoisomers, (+)‐(7′ S ,8′ R ,7″ ,8″ )‐guaiacylglycerol β ‐ O...
Abstract Angiopoietin (Angpt)-Tie receptor 2 (Tie2) plays key roles in vascular development and homeostasis as well pathological remodeling. Therefore, Tie2-agonistic antibody engineered Angpt1 variants have been developed potential therapeutics for ischemic inflammatory diseases. However, their underlying mechanisms Tie2 clustering activation remain elusive the poor manufacturability stability of limit clinical application. Here, we develop a human (hTAAB), which targets membrane proximal...
Arginyl‐tRNA synthetase (ArgRS) is a tRNA‐binding protein that catalyzes the esterification of l ‐arginine to its cognate tRNA. ‐Canavanine, structural analog ‐arginine, has recently been studied as an anticancer agent. Here, we determined crystal structures apo, ‐arginine‐complexed, and ‐canavanine‐complexed forms cytoplasmic free isoform human ArgRS ( h ArgRS). Similar interactions were formed upon binding ‐canavanine or but interaction between Tyr312 oxygen oxyguanidino group was little...