A5046383405- Statistical Methods in Clinical Trials
- RNA Research and Splicing
- Genetics, Bioinformatics, and Biomedical Research
- Microplastics and Plastic Pollution
- Extracellular vesicles in disease
- Computational Drug Discovery Methods
- Recycling and Waste Management Techniques
- Bioinformatics and Genomic Networks
- RNA and protein synthesis mechanisms
- Drug Transport and Resistance Mechanisms
- biodegradable polymer synthesis and properties
- Genomics and Chromatin Dynamics
- Antioxidants, Aging, Portulaca oleracea
- CRISPR and Genetic Engineering
- Bone and Joint Diseases
- Genetic Associations and Epidemiology
- Genomics and Rare Diseases
- Mesenchymal stem cell research
- Bioactive natural compounds
- Fungal and yeast genetics research
- Autism Spectrum Disorder Research
- Analytical Methods in Pharmaceuticals
- Gene expression and cancer classification
- DNA and Biological Computing
- Stress Responses and Cortisol
Daegu-Gyeongbuk Medical Innovation Foundation
2021-2025
Ministry of Food and Drug Safety
2025
National Institute of Food and Drug Safety Evaluation
2025
Korea Advanced Institute of Science and Technology
2008-2025
Lotte Fine Chemical (South Korea)
2025
MRC Laboratory of Molecular Biology
2019-2024
Yeungnam University Medical Center
2024
St. Vincent's Hospital
2019-2022
Kyungpook National University
2021
Korea Institute of Brain Science
2018
As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory,...
The production, use, and waste of plastics increased worldwide, which resulted in environmental pollution a growing public health problem. In particular, microplastics have the potential to accumulate humans mammals through food chain. However, toxicity is not well understood. this study, we investigated 10-50 μm polyethylene following single- 28-day repeated oral administration (three different doses 500, 1000, 2000 mg/kg/day) ICR mice. For investigation, administered orally for repeated....
Currently, polypropylene (PP) is used in various products, thus leading to high daily exposure humans. Thus, it necessary evaluate the toxicological effects, biodistribution, and accumulation of PP microplastics human body. In this study, administration two particle sizes (approximately 5 10-50 µm) did not lead any significant changes several evaluation parameters, including body weight pathological examination, compared with control group ICR mice. Therefore, approximate lethal dose...
The function of a protein is intimately tied to its subcellular localization. Although localizations have been measured for many yeast proteins through systematic GFP fusions, similar studies in other branches life are still forthcoming. In the interim, various machine-learning methods proposed predict localization using physical characteristics protein, such as amino acid content, hydrophobicity, side-chain mass and domain composition. However, there has comparatively little work on...
Spinal cord injury (SCI) interferes with the normal function of autonomic nervous system by blocking circuits between sensory and motor nerves. Although many studies focus on functional recovery after neurological injury, effective neuroregeneration is still being explored. Recently, extracellular vesicles such as exosomes have emerged cell-free therapeutic agents owing to their ability cell-to-cell communication. In particular, released from mesenchymal stem cells (MSCs) potential for...
Autism spectrum disorder (ASD) affects up to 1 in 59 children, and is one of the most common neurodevelopmental disorders. Recent genomic studies have highlighted role rare variants ASD. This study aimed identify genes affected by shared siblings with ASD validate function a candidate gene FRRS1L. By integrating whole genome sequencing data 866 multiplex families from Hartwell Foundation's Research Technology Initiative Speaks MSSNG project, we identified two or more Using (SRVs), selected...
Coffee contains several bioactive compounds, such as alkaloids and phenolic which contribute to its flavor are influenced by the brewing method. The differences in coffee compounds based on conditions have been studied previous research, but no studies yet utilized orbitrap mass spectrometry for this purpose. This study compared non-volatile aromatic hot cold brew using high-resolution spectrometry, followed multivariate statistical analysis including principal component volcano plotting. A...
ABSTRACT Undifferentiated pleomorphic sarcomas (UPSs) are tumours of mesenchymal origin typically seen in soft tissues and histologically characterized by tumour cell multinucleated giant (MGC) infiltration. Here, we report UPS a 23‐month‐old Sprague–Dawley rat, notable for the absence MGC infiltration presence mast cells. The was located left axillary region assessed using haematoxylin eosin, Masson's trichrome, toluidine blue staining, along with immunohistochemistry. Neoplastic cells...
Microplastics (MPs), plastic particles with a diameter of < 5 mm, are intentionally produced or formed by the breakdown variety larger plastics. Polyethylene terephthalate (PET) is common source MPs and PET-MPs prevalent in environment. Owing to their persistence, can enter ecosystems, air, food sources, posing significant health risks. This study aimed investigate toxicological effects vivo accumulation smaller than 10 µm. To track biodistribution, fluorescently labeled were prepared....
Significance Foraging and sleep are two conflicting behaviors in starved animals; however, it remains elusive how metabolic status governs drive. In this study, we show that a biosynthetic pathway for the amino acid serine is transcriptionally up-regulated by starvation adult fly brains. The behavioral response to genetic manipulation of key enzymes involved metabolism supports sleep-suppressing effect starvation. society where daily diet becoming increasingly important quality individuals,...
The increased use of plastics has led to severe environmental pollution, particularly by microplastics-plastic particles 5 mm or less in diameter. These are formed factors such as weathering and ultraviolet irradiation, thereby making pollution worse. This intensifies human exposure microplastics via food chains. Despite potential negative effects, few toxicity assessments on available. In this study, two sizes polytetrafluoroethylene (PTFE) microplastics, approximately μm 10-50 μm, were...
Excessive reactive oxygen species production can detrimentally impact skin cell physiology, resulting in growth arrest, melanogenesis, and aging. Recent clinical studies have found that lactic acid bacteria a special effect directly or indirectly on organs, but the exact mechanism has not been elucidated. In this study, we investigated mechanisms underlying antioxidant protective inhibitory melanin synthesis of Lactobacillus kunkeei culture supernatant (CSK), isolated from Apis mellifera...
Abstract (−)‐Syringaresinol and tricin, isolated from the AcOEt‐soluble extract of whole plants Sasa borealis (Gramineae), showed inhibitory effects on P‐glycoprotein in adriamycin‐resistant human breast cancer cells, MCF‐7/ADR.
Abstract The corneal epithelium acts as a barrier to pathogens entering the eye; epithelial cells are continuously renewed by uni-potent, quiescent limbal stem (LSCs) located at limbus, where cornea transitions conjunctiva. There has yet be consensus on LSC markers and their transcriptome profile is not fully understood, which may due using cadaveric tissue without an intact cell niche for transcriptomics. In this study, we addressed problem single nuclei RNA sequencing (snRNAseq) healthy...
In eukaryotic cells, ribosomal DNA (rDNA) forms the basis of nucleolus. Saccharomyces cerevisiae , 100–200 copies a 9.1-kb rDNA repeat exist as tandem array on chromosome XII. The stability this highly repetitive is maintained through silencing. However, precise mechanisms that regulate silencing are poorly understood. Here, we report S. Ydr026c, which name NTS1 protein 1 (Nsi1), plays significant role in By studying subcellular localization 159 nucleolar proteins, identified 11 proteins...
Recent large-scale genome-wide association studies have identified common genetic variations that may contribute to the risk of amyotrophic lateral sclerosis (ALS). However, pinpointing variants in noncoding regions and underlying biological mechanisms remains a major challenge. Here, we constructed convolutional neural network model with GWAS meta-analysis dataset unravel functional associated ALS based on their epigenetic features. After filtering prioritizing candidates, fine-mapped two...
In inner ear development, phosphatase and tensin homolog (PTEN) is necessary for neuronal maintenance, such as survival accurate nerve innervations of hair cells. We previously reported that Pten conditional knockout (cKO) mice exhibited disorganized fasciculus with apoptosis in spiral ganglion neurons (SGNs). To better understand the genes signaling networks related to auditory neuron we compared profiles differentially expressed (DEGs) using microarray analysis E14.5 cKO wild-type mice....
One of the greatest challenges in cancer genomics is to distinguish driver mutations from passenger mutations. Whereas recurrence a hallmark mutations, it difficult observe recurring noncoding owing limited amount whole-genome sequenced samples. Hence, required develop method predict potentially recurrent mutations.In this work, we developed random forest classifier that predicts regulatory may recur based on features repeatedly appearing given cohort. With breast as model, profiled 35...