A5052054894- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- Bacteriophages and microbial interactions
- Enzyme Structure and Function
- Monoclonal and Polyclonal Antibodies Research
- Antibiotic Resistance in Bacteria
- Photosynthetic Processes and Mechanisms
- Protein Structure and Dynamics
- Cellular transport and secretion
- DNA and Nucleic Acid Chemistry
- Electromagnetic wave absorption materials
- Supramolecular Self-Assembly in Materials
- Antimicrobial Peptides and Activities
- Amino Acid Enzymes and Metabolism
- Genetic and Kidney Cyst Diseases
- Electron Spin Resonance Studies
Korea Institute of Science and Technology
2022-2024
Korea University
2024
Aurora kinase A (AURKA) performs critical functions in mitosis. Thus, the activity and subcellular localization of AURKA are tightly regulated depend on diverse factors including interactions with multiple binding cofactors. How these different cofactors regulate to elicit levels at distinct locations times is poorly understood. Here, we identified a conserved region CEP192, major cofactor AURKA, that mediates interaction AURKA. Quantitative studies were performed map helix (Helix-1) within...
Abstract As large molecular tertiary structures, some proteins can act as small robots that find, bind, and chaperone target protein clients, showing the potential to serve smart building blocks in self‐assembly fields. Instead of using such intrinsic functions, most methodologies for aim de novo‐designed structures with accurate geometric assemblies, which limit procedural flexibility. Here, a strategy enabling polymorphic clustering quaternary proteins, exhibiting simplicity flexibility...
D-Alanylation of the teichoic acids Gram-positive bacterial cell wall plays crucial roles in physiology and virulence. Deprivation D-alanine from Staphylococcus aureus impairs biofilm colony formation, induces autolysis ultimately renders methicillin-resistant S. highly susceptible to antimicrobial agents host defense peptides. Hence, D-alanylation pathway has emerged as a promising antibacterial target against drug-resistant . is mediated via action four proteins encoded by dlt operon,...