Abstract Achieving rapid and effective hemostasis on irregularly shaped, non‐compressible visceral, high‐pressure arterial bleeding wounds remains a critical clinical challenge. Herein, an ultrafast self‐gelling wet adhesive polyethyleneimine/polyacrylic acid/quaternized chitosan (PEI/PAA/QCS) powder is reported as the hemostatic material wound dressing. PEI/PAA/QCS deposited can rapidly absorb large amount of blood to concentrate coagulation factors. Meanwhile, form hydrogel in situ within...

Achieving robust underwater adhesion by bioadhesives remains a challenge due to interfacial water. Herein coacervate-to-hydrogel strategy enhance water repulsion and bulk of is reported. The polyethyleneimine/thioctic acid (PEI/TA) coacervate deposited onto substrates, which can effectively repel completely spread into substrate surface irregularities its liquid water-immiscible nature. physical interactions between further adhesion. Furthermore, driven the spontaneous hydrophobic...

Abstract Upper gastrointestinal (GI) hemorrhage is a common clinical emergency worldwide. Endoscopic hemostasis the current first line treatment. Nevertheless, for patients with severe active bleeding and challenging anatomy, endoscopic management can be still difficult usually requires higher level of surgical expertise. A simple effective method therefore in acute demand. Herein hemostatic hybrid hydrogel comprised hyaluronic acid polyethylene glycol stabilized by thiourea–catechol...

The natural extracellular matrix, with its heterogeneous structure, provides a stable and dynamic biophysical framework biochemical signals to guide cellular behaviors. It is challenging but highly desirable develop synthetic matrix that emulates the fibrous structure macroscopic stability microscopical dynamics contains inductive signals. Herein, we introduce peptide fiber-reinforced hydrogel in which stiff ß-sheet fiber functions as multivalent cross-linker enhance hydrogel's stability....

Abstract Cellular energetics plays an important role in tissue regeneration, and the enhanced metabolic activity of delivered stem cells can accelerate repair regeneration. However, conventional hydrogels with limited network cell adaptability restrict cell–cell interactions activities. In this work, it is shown that a cell‐adaptable hydrogel high dynamics enhances glucose uptake fatty acid β ‐oxidation encapsulated human mesenchymal (hMSCs) compared low dynamics. It further hMSCs dynamic...

Low‐molecular‐weight compounds of certain structural features may form coacervates through liquid‐liquid phase separation (LLPS). These can enter mammalian cells and affect cellular physiology. Controlling the properties inside cells, however, is a challenge. Here, we report photochemical reactions spiropyran (SP)‐based with two wavelengths light, in vitro, cell, animals, generating reactive oxygen species (ROS) for photo‐controlled cell killing. We identify an SP‐containing compound,...

The intricate dynamic feedback mechanisms involved in bone homeostasis provide valuable inspiration for the design of smart biomaterial scaffolds to enhance situ regeneration. In this work, we assembled a biomimetic hyaluronic acid nanocomposite hydrogel (HA-BP hydrogel) by coordination bonds with bisphosphonates (BPs), which are antiosteoclastic drugs. HA-BP exhibited expedited release loaded BP response an acidic environment. Our vitro studies showed that inhibits mature osteoclastic...

Coacervation driven liquid-liquid phase separation of biopolymers has aroused considerable attention for diverse applications, especially the construction microstructured polymeric materials. Herein, a coacervate-to-hydrogel transition strategy is developed to create macroporous hydrogels (MPH), which are formed via coacervation process supramolecular assemblies (SA) built by host-guest complexation between γ-cyclodextrin and anthracene dimer. The weak reversible crosslinks endow SA with...

Biophysical cues of rigid tumor matrix play a critical role in cancer cell malignancy. We report that stiffly confined cells exhibit robust growth spheroids the stiff hydrogel exerts substantial confining stress on cells. The stressed condition activated Hsp (heat shock protein)–signal transducer and activator transcription 3 signaling via transient receptor potential vanilloid 4–phosphatidylinositol 3-kinase/Akt axis, thereby up-regulating expression stemness-related markers cells, whereas...

Low‐molecular‐weight compounds of certain structural features may form coacervates through liquid‐liquid phase separation (LLPS). These can enter mammalian cells and affect cellular physiology. Controlling the properties inside cells, however, is a challenge. Here, we report photochemical reactions spiropyran (SP)‐based with two wavelengths light, in vitro, cell, animals, generating reactive oxygen species (ROS) for photo‐controlled cell killing. We identify an SP‐containing compound,...

Abstract Lead‐free halide double perovskite nanocrystals have emerged as one of the most promising alternatives to lead due their non‐toxicity, high stability, and outstanding optoelectronic properties. However, conventional synthesis methods often result in impurities increased constituent elements. In this study, an efficient water‐oil biphasic interface‐driven approach is introduced for synthesizing lead‐free nanocrystals, enabling controlled structural transformations from 0D 2D 3D...

Using ultraviolet photoelectron spectroscopy (UPS), temperature programmed desorption (TPD), and periodic density functional theory (DFT), we have investigated the oxidation chemistry of diamond (111) surface following its exposure to atomic oxygen generated from a remote radio frequency discharge. Partial O uptake occurs on C(111) 2 × 1 at room without lifting reconstruction. A → transition full monolayer coverage is only achieved oxygenation elevated temperatures (400 °C). Exchange...

We report the creation of polymeric micro/nanostructures which exhibit distinct chemical and physical characteristics from matrix poly(N-vinyl carbazole) (PVK). The structure formation is based on atomic force microscopy (AFM) facilitated cross-linking oxygenation. reaction PVK with AFM lithographically induced nanoscale discharge produces raised structures in bridge oxygen links neighboring carbazole groups. by converts initially insulating to chemically modified conducting patterns through...

The generation and conduction of photoelectrons in ligated metallic Au NPs are demonstrated, their key factors include tunneling photoexcited electrons, the close packing NP network, increased photoelectron-to-intrinsic electron ratio associated with ligand passivation. In view inherent characteristics, may provide a promising alternative to semiconductors photocurrent photodetection applications.

In this paper, we successfully demonstrated the fabrication of highly ordered and large-scale P3HT:PCBM nanowires via a slow-drying method, which allows for convenient cost-effective preparation well-defined nanostructures with large domains. The formation organic can be explained by self-organization polymer chains under favorable thermodynamic conditions in process. Furthermore, C–V measurements revealed that possess high capacitance. This supercapacitive behavior is related to their...

We have observed the native oxide decomposition and local growth on 6H-silicon carbide (0001) surface induced by atomic force microscopy (AFM). When biased AFM probe was scanned over areas, decomposed assembled into protruded lines. The is accompanied simultaneous graphitization of leading to metal–semiconductor contact as evidenced in I–V characteristics. immobilized longer bias duration applied, direct oxidation silicon (SiC) achieved. dielectrical properties SiC were also investigated...

We report, for the first time, native oxide decomposition/etching and direct local growth on 6H-SiC (0001) surface induced by atomic force microscopy (AFM). Surface was decomposed assembled into protruded lines when negatively biased AFM tip scanned over areas. The mechanism of decomposition found to be governed Fowler-Nordheim emission current enhanced tip. Direct SiC achieved immobilized longer bias duration applied. In particular, aspect ratio grown several times higher than that Si...

Size and ligand effects are the basis for novel properties applications of metallic nanoparticles (NPs) in nanoelectronics, optoelectronics, biotechnology. This work reports first observation enhanced photoelectron emission from Au NPs ligated by alkanethiols. The enhancement is based on a conceptually new mechanism: AuNP provides electrons while alkane emits due to its low or negative electron affinity. Moreover, AuNP−ligand chemical bonding found significantly facilitate transmission...

We report a method to initiate and investigate electrical discharges of ambient air/water molecules in nanometer-sized gap. Our methodology is based on typical atomic force microscopy (AFM) setup, which cylinder discharge gap < or =5 nm could be configured between the AFM probe substrate. observed highly localized stochastic nanoexplosions probability dominated by electric field, material-specific surface reactions, humidity. results, coupled with boundary element (BEM), finite (FEM),...