A5046585294- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- CAR-T cell therapy research
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- HER2/EGFR in Cancer Research
- Liver physiology and pathology
- Endoplasmic Reticulum Stress and Disease
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Organ Transplantation Techniques and Outcomes
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer, Lipids, and Metabolism
- Hippo pathway signaling and YAP/TAZ
- PI3K/AKT/mTOR signaling in cancer
- Immune Response and Inflammation
Beijing VDJBio (China)
2023
Peking University Cancer Hospital
2022
Peking University
2022
Yanbian University
2020-2021
Second Military Medical University
1995-1998
Lung adenocarcinoma (LUAD) is a common type of lung cancer with high frequent metastasis and death rate.However, genes responsible for LUAD are still largely unknown.Here, we identify an important role ras homolog family member V (RHOV) in using combination bioinformatic analysis functional experiments.Bioinformatic shows five hub driver (RHOV, ZIC5, CYP4B1, GPR18 TCP10L2), among which RHOV the most significant gene associated metastasis.High expression predicted shorter overall survival...
The Warburg effect (aerobic glycolysis) is a hallmark of cancer and becoming promising target for diagnosis therapy. Phosphoglycerate kinase 1 (PGK1) the first adenosine triphosphate (ATP)-generating glycolytic enzyme in aerobic glycolysis pathway plays an important role development progression. However, how microRNAs (miRNAs) regulate PGK1-mediated remains unknown. Here, we show that miR-16-1-3p inhibits PGK1 expression by directly targeting its 3′-untranslated region. Through inhibition...
Aerobic glycolysis (Warburg effect), a hallmark of cancer, plays critical role in cancer cell growth and metastasis; however, direct inhibition the Warburg effect remains largely unknown. Herein, transcription factor OVO-like zinc finger 2 (OVOL2) is demonstrated to directly repress expression several glycolytic genes, blocking breast tumor metastasis vitro vivo. OVOL2 inhibits by recruiting nuclear receptor co-repressor (NCoR) histone deacetylase 3 (HDAC3). The suppressor p53, key regulator...
The EGFR-RAS-ERK pathway plays a key role in cancer development and progression. However, the integral assembly of signaling complexes from upstream component EGFR to downstream ERK is largely unknown. Here, we show that hematopoietic PBX-interacting protein (HPIP) interacts with all classical components forms at least two overlapping components. Experiments HPIP knockout or knockdown chemical inhibition expression showed required for complex formation, activation, signaling–mediated...
CD8+ T lymphocyte-mediated immunity strategies have represented attractive weapons against breast cancer (BC) recently. However, the mechanisms underlying T-lymphocyte infiltration still remain obscure. Here, using bioinformatics analysis, we identified four hub prognostic genes related to (CHMP4A, CXCL9, GRHL2, and RPS29), among which CHMP4A was most significant gene. High mRNA expression significantly associated with longer overall survival (OS) in BC patients. Functional experiments...
Abstract Aerobic glycolysis is a hallmark of cancer and regulated by growth factors, protein kinases transcription factors. However, it remains poorly understood how these components interact to regulate aerobic coordinately. Here, we show that sine oculis homeobox 1 (SIX1) phosphorylation integrates factors (e.g. TGFβ, EGF) control determines its tumor-promoting activity. SIX1 phosphorylated at serine 225 (S225) factors-activated ERK1/2 responsible for stimulated some dephosphorylated the...
A recombinant vaccinia virus expressing marine granulocyte-macrophage colony-stimulating factor (VVGM-CSF) was tested for its antitumor activity. Murine pulmonary metastasis established by injecting 2×105 B16F10 melanoma cells into the tail vein of C57BL/6 mice. Three days after inoculation, WGM-CSF or VVTK, a thymidine kinase gene deficient control virus, were injected intraperitoneally twice weekly 2 weeks. Two weeks later, mice sacrificed and foci counted. The results demonstrated that...
Mouse FBL-3 erythroleukemia cells were transfected with recombinant human interleukin-6 (rhIL-6) gene and a clone secreting IL-6 was selected (i.e., FBL-3-IL-6+). The cell inoculated into C57BL/6 mouse. growth of tumors observed histologic analyses the tumorsin situ, liver, spleen bone marrow performed after inoculation. mice wild-type used as control. results showed that later tumor occurrence, slower development, lower pathological changes degree longer survival time in experimental group...