A5046391784- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- Immune cells in cancer
- Circular RNAs in diseases
- IL-33, ST2, and ILC Pathways
- Probiotics and Fermented Foods
- Congenital heart defects research
- Gastric Cancer Management and Outcomes
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- Gut microbiota and health
- Barrier Structure and Function Studies
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- TGF-β signaling in diseases
Dalian Medical University
2022-2024
Aerobic glycolysis (Warburg effect), a hallmark of cancer, plays critical role in cancer cell growth and metastasis; however, direct inhibition the Warburg effect remains largely unknown. Herein, transcription factor OVO-like zinc finger 2 (OVOL2) is demonstrated to directly repress expression several glycolytic genes, blocking breast tumor metastasis vitro vivo. OVOL2 inhibits by recruiting nuclear receptor co-repressor (NCoR) histone deacetylase 3 (HDAC3). The suppressor p53, key regulator...
Abstract Tumor immune microenvironment exerts a profound effect on the population of infiltrating cells. Tissue inhibitor matrix metalloproteinase 1 (TIMP1) is frequently overexpressed in variety cells, particularly during inflammation and tissue injury. However, its function cancer immunity remains enigmatic. In this study, we find that TIMP1 substantially up-regulated tumorigenesis through analyzing bioinformatics databases, which further confirmed by IHC microarrays clinical samples. The...
MicroRNAs (miRNAs) are small, noncoding RNAs that have tissue- and cell-specific expression. They the ability to regulate malignant proliferation transformation of tumour cells. The research focussed on expression role miR-1297 in melanoma. We firstly found is up-regulated melanoma tissues cell lines. Functionally, phosphatase tension homology deleted chromsome ten gene (PTEN) was used as a potential target for detected using Western blotting immunohistochemistry (IHC). then chemical...
Abstract Paediatric pneumonia is a respiratory infection that affects infants and young children under the age of 3. This disease leading cause infant child mortality in developing countries because weak immune system children. The difficulty length time required to identify pathogen causative agent are main reasons for this high rate. In addition, identification certain agents particularly important treatment paediatric pneumonia. study, we explored possible mechanisms by which pathogenic...
Objective To explore the expression of microRNA (miRNA, miR)-449a in liver cancer, effect on migration and invasion, possible regulatory mechanism. Methods Eighteen cases cancer tissues adjacent were collected. The miR-449a tissues, 4 kinds human cell lines, normal hepatocytes was detected by reverse transcriptase-polymerase chain reaction (RT-PCR). lines transfected with mimic negative control (NC) plasmid. after transfection RT-PCR. number invasion two groups measured Transwell...
Review on TGFBI (transforming growth factor, beta-induced, 68kDa), with data DNA, the protein encoded, and where gene is implicated.
Abstract Background Without an effective strategy for targeted therapy, glioblastoma multiforme (GBM) is still incurable, with a median survival of only 15 months. Both chronic inflammation and epigenetic reprogramming are hallmarks cancer. However, the mechanisms consequences their cooperation in GBM remain unknown. Methods Western blotting was carried out to detect levels various histone modifications affected by NF-κB signalling. Then, RNA-seq used screen genes encoding methyltransferases...