A5078531561- Vehicle emissions and performance
- Atmospheric chemistry and aerosols
- Pancreatic function and diabetes
- Poxvirus research and outbreaks
- RNA Research and Splicing
- Influenza Virus Research Studies
- Diet, Metabolism, and Disease
- PI3K/AKT/mTOR signaling in cancer
- Autophagy in Disease and Therapy
- Lung Cancer Treatments and Mutations
- Calcium signaling and nucleotide metabolism
- Glycosylation and Glycoproteins Research
- Respiratory viral infections research
- RNA and protein synthesis mechanisms
- Animal Virus Infections Studies
- Cancer Research and Treatments
- HER2/EGFR in Cancer Research
- RNA modifications and cancer
- Herpesvirus Infections and Treatments
- Lipid metabolism and disorders
- Bacillus and Francisella bacterial research
- Mosquito-borne diseases and control
Chinese Academy of Agricultural Sciences
2023-2025
Nanjing University
2024
Abstract Motivation Due to the varying delivery methods of mRNA vaccines, codon optimization plays a critical role in vaccine design improve stability and expression proteins specific tissues. Considering many-to-one relationship between synonymous codons amino acids, number sequences encoding same acid sequence could be enormous. Finding stable highly expressed from vast space using silico can generally viewed as path-search problem or machine translation problem. However, current deep...
The H5N6 avian influenza virus (AIV) is constantly undergoing recombination and evolution with other subtypes of AIV, resulting in various types recombinant viruses. However, the risk to human public health different viruses remains unclear. Recently, two were isolated from chickens. One possessed six internal genes originating H9N2, named A/Chicken/Hubei/112/2020 (H5N6) (abbreviated 112); PB2, PB1, PA, NP H5N1, while M NS derived A/Chicken/Hubei/125/2020 125). Here, we investigated receptor...
The 2022 monkeypox outbreak involved rapid global dissemination, prompting research into animal models for the virus (MPXV), including non-human primates and mice. However, studies utilizing rabbits as remain limited. In this study, we established three rabbit using current epidemic MPXV strain. Following intravenous injection, adult exhibited characteristic clinical manifestations, widespread rash fever, with viral replication in skin, lungs, testes, resulting severe pathological damage by...
The EGFR-RAS-ERK pathway plays a key role in cancer development and progression. However, the integral assembly of signaling complexes from upstream component EGFR to downstream ERK is largely unknown. Here, we show that hematopoietic PBX-interacting protein (HPIP) interacts with all classical components forms at least two overlapping components. Experiments HPIP knockout or knockdown chemical inhibition expression showed required for complex formation, activation, signaling–mediated...
ABSTRACT Autophagy is a cellular self-defense mechanism by which cells can kill invading pathogenic microorganisms and increase the presentation of components pathogens as antigens. Contrarily, utilize autophagy to enhance their own replication. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) NSP6 interact with ATPase proton pump component inhibit lysosomal acidification, was implicated in process. However, research on how SARS-CoV-2 affected autophagy, its impact virus...
Background: Multiple myeloma (MM) is different from leukemia on pathogenesis, clinical features, and treatment prognosis, it remains a type of incurable cancer although there are such as hematopoietic stem cell transplantation CAR-T, etc. One the important characteristics that MM cells focally distributed within bone marrow. Aims: In order to mimic local distribution cells, we try establish in vitro vivo model by technology magnetically empowered tumor (MET) NK (MENK). Methods: 1) Myeloma...