A5052599956- Microbial Community Ecology and Physiology
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Herpesvirus Infections and Treatments
- COVID-19 Clinical Research Studies
- Orthopedic Infections and Treatments
- Spine and Intervertebral Disc Pathology
- Neurogenetic and Muscular Disorders Research
- Osteoarthritis Treatment and Mechanisms
- Spinal Cord Injury Research
- Gut microbiota and health
- COVID-19 epidemiological studies
- Amyotrophic Lateral Sclerosis Research
- Bone Metabolism and Diseases
- Hematological disorders and diagnostics
- Extracellular vesicles in disease
- Viral Infections and Immunology Research
- Poxvirus research and outbreaks
- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- Neurological diseases and metabolism
- Kawasaki Disease and Coronary Complications
- Spondyloarthritis Studies and Treatments
- Immune responses and vaccinations
- Lipid metabolism and disorders
Fujian Medical University
2023-2025
First Affiliated Hospital of Fujian Medical University
2023-2025
There is a controversy in studies of circulating inflammatory proteins (CIPs) association with osteoporosis (OP) and fractures, it unclear if these two conditions are causally related. This study used MR analyses to investigate the causal associations between 91 CIPs OP 9 types fractures. Genetic variants data for CIPs, OP, fractures were obtained from publicly available genome-wide (GWAS) database. We inverse variance weighted (IVW) as primary analysis, pleiotropy, heterogeneity tests...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic of severe disease 2019 (COVID-19). Staphylococcus aureus is one the most common pathogenic bacteria in humans, rheumatoid arthritis (RA) among prevalent autoimmune conditions. RA significant risk factor for SARS-CoV-2 and S. infections, although mechanism infection conjunction with has not been elucidated. The purpose this study to investigate biomarkers targets between infections using bioinformatics...
Abstract Background Numerous investigations have suggested links between circulating inflammatory proteins (CIPs) and spinal degenerative diseases (SDDs), but causality has not been proven. This study used Mendelian randomization (MR) to investigate the causal associations 91 CIPs cervical spondylosis (CS), prolapsed disc/slipped disc (PD/SD), canal stenosis (SCS), spondylolisthesis/spondylolysis. Methods Genetic variants data for SDDs were obtained from genome‐wide association studies...
It remains controversial whether lipids affect osteoporosis (OP) or bone mineral density (BMD), and causality has not been established. This study aimed to investigate the genetic associations between lipids, novel non-statin lipid-lowering drug target genes, OP BMD. Mendelian randomization (MR) method was used explore 179 lipid species OP, Drug-target MR analysis causal angiopoietin-like protein 3 (ANGPTL3) apolipoprotein C3 (APOC3) inhibitors on The IVW results with Bonferroni correction...
Coronavirus disease 2019 (COVID-19) survivors are concerned about the likelihood of developing further diseases. This study examines global trends in scientific research on diabetes associated with COVID-19 from several perspectives. Bibliometric analyses used to undertake a review literature. The Web Science Core Collection (WoSCC) database was acquire bibliographic information related Jan 2020 Dec. 2023. visual map built via advanced CiteSpace 6.2.R6. 7,348 papers were found. Khunti...
Background The coronavirus disease (COVID-19) is a pandemic that threatens worldwide public health, and rheumatoid arthritis (RA) the most common autoimmune disease. COVID-19 RA are each strong risk factors for other, but their molecular mechanisms unclear. This study aims to investigate biomarkers between from mechanism of pyroptosis find effective disease-targeting drugs. Methods We obtained gene shared by COVID-19, (GSE55235), using bioinformatics analysis then did principal component...
Abstract Background Finite element analysis (FEA) was performed to investigate the biomechanical differences between different adjunct fixation methods for oblique lumbar interbody fusion (OLIF) and further analyze its effect on adjacent segmental degeneration. Methods We built a single-segment (Si-segment) finite model (FEM) L4-5 double-segment (Do-segment) FEM L3-5. Each complete supplemented modified, both developed two surgical models of OLIF with assisted internal fixation. They were...
Background The causal associations between infections with human herpes viruses (HHVs) and amyotrophic lateral sclerosis (ALS) has been disputed. This study investigated the simplex virus (HSV), varicella-zoster (VZV), Epstein–Barr (EBV), cytomegalovirus (CMV), HHV-6, HHV-7 ALS through a bidirectional Mendelian randomization (MR) method. Methods genome-wide association studies (GWAS) database were analyzed by inverse variance weighted (IVW), MR-Egger, median, simple mode, mode methods....
Regulated cell death is a form of that actively controlled by biomolecules. Several studies have shown regulated plays key role after spinal cord injury. Pyroptosis and ferroptosis are newly discovered types deaths been to exacerbate inflammation lead in damaged cords. Autophagy, complex interconnected with various mechanisms, has garnered significant attention the study This injury triggers not only but also cellular survival responses. Multiple signaling pathways play pivotal roles...
Abstract Trained immunity is a phenomenon in which brief exposure to an infectious agent or vaccine can induce long-lasting changes the host's immune system, enhancing protection against subsequent infections. The concept of trained has significant impact on field immunology and potential revolutionize how we approach vaccination disease control. Investigations into are rapidly advancing have led development new vaccines immunotherapeutic strategies that harness power this phenomenon. While...
Varicella-zoster virus (VZV) infection downregulates surface major histocompatibility complex class I (MHC-I) expression and retains MHC-I in the Golgi of infected cells. However, underlying mechanism is not fully understood. The VZV IE4 protein a multifunctional that essential for infection. In this study, human leucocyte antigen C (HLA-C) was identified as novel cellular factor associated with IE4. Ectopically expressed co-localizes HLA-C, sequesters HLA-C to MHC-I. VZV, mutated...
Abstract Objectives We aimed to explore the bacterial community composition following ocean infection using an animal model. Methods This animal-based experiment was conducted from September 2019 November 2019. Eighteen seawater filter membranes were collected Changle City, Fujiian Province, China, on 8, Ten used for implantation. Eight that in culture exploration of bacteria assigned group (SG). Fourteen healthy adult New Zealand rabbits randomly divided into experimental (EG) and control...