A5102417925- Drug Transport and Resistance Mechanisms
- Autism Spectrum Disorder Research
- RNA Interference and Gene Delivery
- HIV/AIDS drug development and treatment
- Genetics and Neurodevelopmental Disorders
- Advanced Computational Techniques and Applications
- Child Development and Digital Technology
- Genomic variations and chromosomal abnormalities
- Advanced Algorithms and Applications
- Pediatric Hepatobiliary Diseases and Treatments
- Long-Term Effects of COVID-19
- Machine Fault Diagnosis Techniques
- Advanced Sensor and Control Systems
- Stress Responses and Cortisol
- Robotic Path Planning Algorithms
- Machine Learning in Bioinformatics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Face recognition and analysis
- Technology and Security Systems
- COVID-19 and Mental Health
- Attention Deficit Hyperactivity Disorder
- Simulation and Modeling Applications
- Behavioral and Psychological Studies
- Distributed and Parallel Computing Systems
- Intravenous Infusion Technology and Safety
Children's Hospital of Fudan University
2018-2025
Jimei University
2024
Changshu No.1 People's Hospital
2023
Soochow University
2023
Nanjing University of Science and Technology
2022
Beijing University of Chemical Technology
2013
Beijing University of Posts and Telecommunications
2012
Weinan Normal University
2012
State Key Laboratory of Coal Resources and Safe Mining
2011
Beijing National Laboratory for Molecular Sciences
2009
Abstract Multidrug resistance protein 7 (MRP7; ABCC10) is an ATP-binding cassette transporter which able to transport amphipathic anions and confer docetaxel and, a lesser extent, vincristine paclitaxel. Whereas some detail on the profile of MRP7 known, activities pump have not been completely determined. Here, it shown by analysis MRP7-transfected HEK293 cells that, in addition natural product agents, also nucleoside-based such as anticancer agents cytarabine (Ara-C) gemcitabine, antiviral...
Mutations in CHD8, chromodomain helicase DNA-binding protein 8, are among the most replicated and common findings genetic studies of autism spectrum disorder (ASD). The CHD8 is believed to act as a transcriptional regulator by remodeling chromatin structure recruiting histone H1 target genes. mechanism which deficiency causes ASD has not been fully elucidated. We examined expression human mouse brains using both immunohistochemistry RNA situ hybridization. performed utero electroporation,...
Cognitive assessment can reveal a person's cognitive processing and behavioral patterns, making it an indispensable component of autism intervention prognosis. Existing machine-assisted methods primarily focus on children's performance outcomes, overlooking distinctive models, particularly characteristics eye movement behavior, which have been demonstrated as the most direct indicators abilities. In this study, we explore eye-tracking biomarkers for assisting through series meticulously...
Incidence of children with autism spectrum disorder (ASD) has increased an average rate 1% worldwide. Clinical ASD screening, especially for screening is a laborious and skilled task; however, there no objective effective method automating screening. Analyzing characteristics in predefined motion behavior protocols attempted to provide automatic solutions A novel protocol, response name (RTN), proposed this article clinical validation diagnosis. The RTN jointly designed partners, gaze...
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> Attention-deficit/hyperactivity disorder (ADHD) is a childhood-onset neurodevelopmental with prevalence ranging from 6.1 to 9.4%. The main symptoms of ADHD are inattention, hyperactivity, impulsivity, and even destructive behaviors that may have long-term negative influence on learning performance or social relationships. Early diagnosis treatment provide the best chance reducing...
Early screening of autism spectrum disorder (ASD) is crucial since early intervention evidently confirms significant improvement functional social behavior in toddlers. This article attempts to bootstrap the response-to-instructions (RTIs) protocol with vision-based solutions order assist professional clinicians an automatic diagnosis. The correlation between detected objects and toddler's emotional features, such as gaze, constructed analyze their autistic symptoms. Twenty toddlers 16-32...
Mutations in CHD8 are among the most common autism-causing genetic defects identified human genomics studies. Therefore, many labs have attempted to model this disorder by generating mice with mutations Chd8. Using a gene trap inserted after Exon 31, we created novel Chd8 mutant mouse (Chd8+/E31T ) and characterized its behavior on several different assays thought face validity for condition, attempting both core symptoms (repetitive behaviors social communication impairments) comorbidities...
有关孤独症及其他相关疾病的 定义、发病机制、诊断及治疗等方面的研究不断深入, 使得孤独症的内涵和外沿得到了拓展并引入了孤独 症谱系障碍(autism spectrum disorders, ASDs)这一新 的概念.人们逐渐认识到孤独症并非是一个独立的 疾 病 单 元 , 而 是 与
Background Mutations in the STAMBP gene, which encodes a deubiquitinating isopeptidase called STAM-binding protein, are related to global developmental delay, microcephaly, and capillary malformation. Owing limited number of reported cases, functional phenotypic characteristics variants require further elucidation. Materials methods Whole exome sequencing was performed on patient presenting with neurodevelopmental disorder. Novel compound heterozygous mutations [c.843_844del (p.C282Wfs*11)...
Interpersonal communication facilitates symptom measures of autistic sociability to enhance clinical decision-making in identifying children with autism spectrum disorder (ASD). Traditional methods are carried out by practitioners assessment scales, which subjective quantify. Recent studies employ engineering technologies analyze children's behaviors quantitative indicators, but these only generate specific rule-driven indicators that not adaptable diverse interaction scenarios. To tackle...
Diabetes is a chronic noncommunicable disease, which related to lifestyle, environmental and other factors. The main disease of diabetes the pancreas. Inflammation, oxidative stress factors can interfere with conduction various cell signaling pathways, thus inducing pancreatic tissue lesions diabetes. Precision medicine covers epidemiology, preventive medicine, rehabilitation clinical medicine. On basis precision big data analysis, this paper takes pancreas as target analyze signal pathway...
Autism Spectrum Disorders (ASD) are characterized by impairments in joint attention (JA) comprising two components: responding to JA (RJA) and initiating (IJA). RJA IJA considered interrelated aspects of JA, related different stages infant development. While recent technologies have been used characterize emerging earlier childhood, only a limited number studies attempted explore IJA, which progressively becomes evident as hallmark ASD. This study aims achieve the social recognition both...
Early screening for ASD (Autism Spectrum Disorder) is crucial and also challenging due to the limited medical resource. Expressing Needs with Pointing (ENP) a low-cost yet effective protocol early screening. However, current methods need manually trim video analyzing ENP protocol, which labour-intensive. Also, they detect discriminative signs separately high-level clues (e.g., pose, object detection), but ignore temporal action relationships between child clinician, usually leads invalid...
In order to overcome the difficulty of tuning proportion integration differentiation (PID) parameters, a PID parameter self-tuning method based on firefly algorithm improved by Newton's law universal gravitation (LOGFA) and deep belief network (DBN) is proposed. Compared with FA, LOGFA cannot only maintain evolutionary advantage original but also can effectively improve accuracy convergence ability algorithm. The DBN train each layer neural separately, which greatly improves training...