A5101912467- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Family and Disability Support Research
- Genomic variations and chromosomal abnormalities
- Child Development and Digital Technology
- Child Nutrition and Feeding Issues
- Congenital heart defects research
- Behavioral and Psychological Studies
- Chromosomal and Genetic Variations
- Infant Development and Preterm Care
- Vascular Malformations Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- Virology and Viral Diseases
- Robotic Path Planning Algorithms
- Formal Methods in Verification
- Glycosylation and Glycoproteins Research
- Family Support in Illness
- Embedded Systems Design Techniques
- Functional Brain Connectivity Studies
- Genomics and Rare Diseases
- Genetic and Kidney Cyst Diseases
- Vascular anomalies and interventions
- Renal and related cancers
- Pancreatic function and diabetes
- Renal cell carcinoma treatment
Children's Hospital of Fudan University
2015-2025
To evaluate the effects of a 26-week, high-intensity, parent-implemented Early Start Denver Model (P-ESDM) intervention on developmental outcomes, severity autism spectrum disorder (ASD), and parental stress ASD toddlers in China. Subjects P-ESDM group (n = 23) were recruited from 1.5- to 2.5-year-old who screened positive Xuhui Minhang Districts diagnosed with ASD. A community (comparison) age-matched 20) was other areas. attended 1.5-hr parent coaching per week for 26 weeks, those received...
The incidence of autism spectrum disorders (ASD), a neurodevelopmental condition associated with challenges in social communication, has witnessed remarkable surge recent years, adverse effects on individuals, families, and society at large. Early screening for ensures timely access to interventions, yet lacks systematic methodical approaches objectively quantifying behaviors. In response this, we propose protocol early assistive screening, termed the Express-Needs-with-Pointing (ENP), which...
Cognitive assessment can reveal a person's cognitive processing and behavioral patterns, making it an indispensable component of autism intervention prognosis. Existing machine-assisted methods primarily focus on children's performance outcomes, overlooking distinctive models, particularly characteristics eye movement behavior, which have been demonstrated as the most direct indicators abilities. In this study, we explore eye-tracking biomarkers for assisting through series meticulously...
Objective: To explore the intervention effects of skill training for parents with autism child (STPAC) on toddlers spectrum disorder (ASD). Methods: A multicenter non-randomized concurrent controlled study design was conducted. Thirty children ASD aged 15-30 months, first diagnosed at Children's Hospital Fudan University, First Jilin and Chengdu Women's Central from 2019 to 2020, were enrolled in STPAC group. who visited same hospitals during period but refused selected as control The group...
The cell adhesion molecule L1-like (CHL1 or CALL) gene is located on chromosome 3p26.3, and it highly expressed in the central peripheral nervous systems. protein encoded by this a member of L1 family neural molecules, plays role system development synaptic plasticity. Moreover, studies mice have revealed that CHL1 prime candidate for dosage-sensitive autosomal form mental retardation. To date, four patients with microdeletion two microduplication 3p26.3 encompassing only been reported...
The reported prevalence of autism spectrum disorder (ASD) has been increasing rapidly in many parts the world. However, data on its China are largely missing. Here, we assessed suitability modified Chinese version a newly-developed ASD screening tool, Modified Autism Spectrum Rating Scales (MC-ASRS) for children aged 6-12 years, through comparison with Social Responsiveness Scale (SRS) that widely used screening. We recruited parents/caregivers 1588 typically-developing and 190 years to...
Early identification and intervention for children with global developmental delay (GDD) can significantly improve their prognosis reduce the possibility of developing intellectual disability in future. This study aimed to explore clinical effectiveness a parent-implemented early program (PIEIP) GDD, providing research basis extended application this strategy future.During period between September 2019 August 2020, aged 3 6 months diagnosed GDD were selected from each center as experimental...
Most children with autism spectrum disorder (ASD) are not diagnosed until the age of 4, thus missing opportunity for early intervention. The objective this study was to investigate feasibility an screening program ASD applied during well‐child visits in a community‐based sample. lasted 4 years and divided into two stages. Stage I involved implementation basic model 2014. Toddlers received level 1 via section A Chinese‐validated version Checklist Autism (CHAT‐23) 18‐ 24‐month Xuhui District,...
Propranolol has been widely used in the treatment of infantile hemangiomas since 2008. This study aimed to investigate complications systemic propranolol therapy for hemangiomas, especially its effect on infants' physical growth. In this study, was given at a dose 2 mg/kg per day. Abnormal symptoms and growth parameters were recorded detail during therapy. Follow-up visits arranged continue least through age years. A total 76 patients with complete enrolled into study. Complications minor,...
SHANK3 deficiency represents one of the most replicated monogenic risk factors for autism spectrum disorder (ASD) and caused ASD presents a unique opportunity to understand underlying neuropathological mechanisms ASD. In this study, genetic tests, comprehensive clinical neurobehavioral evaluations, as well multimodal structural MRI using voxel-based morphometry (VBM) tract-based spatial statistics (TBSS) were conducted in group (N = 14 with defects), controls 26 idiopathic without defects)...
Motor impairments are prevalent in children with autism spectrum disorder (ASD) and persistent across age. Our current study was designed to investigate motor deficits Chinese toddlers ASD explore the relationships between social communication skills.For this cross-sectional study, we recruited a total of 210 aged 18 36 months during December 2017 2020. Griffiths Developmental Scales-Chinese (GDS-C), Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) Communication Symbolic...
Objectives: Autism spectrum disorder (ASD) is a neurodevelopmental with genetic and clinical heterogeneity. Owing to the advancement of sequencing technologies, an increasing number ASD-related genes have been reported. We designed targeted panel (TSP) for ASD based on next-generation (NGS) provide strategies testing its subgroups. Methods: TSP comprised 568 analyzed both single nucleotide variations (SNVs) copy (CNVs). The Diagnostic Observation Schedule (ADOS) Griffiths Mental Development...
AbstractAbstractAutism Spectrum Disorders (ASD) remain a healthcare challenge and gain considerable attention due to the increasing prevalence rates insupportable burden on families society. It is noted that recognition of children's emotional states plays an important role in evaluation intervention process ASD. In this paper, we aim address problem automatic ASD children social interactive scenarios. Since child can be unconstrained realistic scenarios, face occlusion under pose variations...
Autism spectrum disorder (ASD) is a neurodevelopmental in which genetics plays key aetiological role. The gene encoding NAD(P)H steroid dehydrogenase-like protein (NSDHL) expressed developing cortical neurons and glia, its mutation may result intellectual disability or congenital hemidysplasia. An 8-year-old boy presented with 260-kb NSDHL-containing duplication at Xq28 (151,868,909 – 152,129,300) inherited from his mother. His clinical features included defects social communication...
SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3)-caused autism spectrum disorder (ASD) may present a unique opportunity to clarify the heterogeneous neuropathological mechanisms of ASD. However, specificity commonality disrupted large-scale brain organization in SHANK3-deficient children remain largely unknown. The study combined genetic tests, neurobehavioral evaluations, magnetic resonance imaging, aiming explore disruptions both local networked cortical structural ASD with without...
Autism spectrum disorders are a group of neurodevelopmental with strong genetic etiology. Cytogenetic abnormalities have been detected in 5% to 10% the patients autism disorders. In this study, authors present clinical and array-based comparative genomic hybridization evaluation 4-year-old male disorder mental retardation. The patient was found carry de novo duplication chromosome 8p22-21.3 1.0 Mb as ascertained by quantitative polymerase chain reaction, region encompassed 3 genes including...
Objective: To explore the relationship between fathers' nursing time and maternal parenting stress of children with autism spectrum disorder(ASD). Method: Mothers 98 ASD who were first diagnosed in department Child Health Care, Children's Hospital Fudan University during June 2015 to January 2016 included group, mothers 92 typical from a Community Maternal kindergarten control group. The evaluation stress, parents' other related factors cross-sectionally analyzed. Interview was conducted...
Interpersonal communication facilitates symptom measures of autistic sociability to enhance clinical decision-making in identifying children with autism spectrum disorder (ASD). Traditional methods are carried out by practitioners assessment scales, which subjective quantify. Recent studies employ engineering technologies analyze children's behaviors quantitative indicators, but these only generate specific rule-driven indicators that not adaptable diverse interaction scenarios. To tackle...
Autism spectrum disorder (ASD) is a neurodevelopmental whose prevalence has increased rapidly in recent decades. Advances the fields of intervention for ASD have contributed to more optimistic outcome children with ASD. Furthermore, development early detection, screening, and diagnosis highlighted importance young The present article reviews commonly used approaches China, including recently introduced originally developed Chinese models intervention, then briefly summarizes progress...
Early screening for ASD (Autism Spectrum Disorder) is crucial and also challenging due to the limited medical resource. Expressing Needs with Pointing (ENP) a low-cost yet effective protocol early screening. However, current methods need manually trim video analyzing ENP protocol, which labour-intensive. Also, they detect discriminative signs separately high-level clues (e.g., pose, object detection), but ignore temporal action relationships between child clinician, usually leads invalid...