A5058955976- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Sesquiterpenes and Asteraceae Studies
- Traditional and Medicinal Uses of Annonaceae
- SARS-CoV-2 and COVID-19 Research
- Protein Tyrosine Phosphatases
- Sirtuins and Resveratrol in Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Phytochemical Studies and Bioactivities
- Bioactive Compounds and Antitumor Agents
- Influenza Virus Research Studies
- Inflammasome and immune disorders
- Computational Drug Discovery Methods
- Plant-derived Lignans Synthesis and Bioactivity
Chinese Academy of Sciences
2017-2024
Shanghai Institute of Materia Medica
2017-2024
University of Chinese Academy of Sciences
2017-2021
ShanghaiTech University
2017-2021
Two novel dimeric sesquiterpenoids with potent anti-inflammatory activity were characterized from <italic>Ainsliaea macrocephala</italic> through a molecular networking-based dereplication strategy.
Ainsliatriolides A (1) and B (2), two guaianolide sesquiterpenoid trimers possessing an unprecedented skeleton, were isolated from Ainsliaea fragrans. Their structures elucidated through extensive analysis of spectroscopic data confirmed by single-crystal X-ray diffraction experiment. are first examples compound trimerized sesquiterpenoids different C–C linkages (type A, 4–2′/15–14′; type B, 15′-15″). Ainsliatriolide displayed potent cytotoxicity with averaged IC50 value 1.17 μM against four...
Two guaianolide sesquiterpenoid tetramers named ainsliatetramers A and B were separated from Ainsliaea fragrans. Through spectroscopic analyses, especially the band-selective CT–HSQC CT–HMBC techniques, complex skeleton was constructed four sesquiterpene units via three different linkages. biosynthetic pathway proposed featuring a Michael addition regular hetero-Diels–Alder cycloaddition. Both exhibited potent cytotoxicity against human cancer cell lines with IC50 values ranging 2 to 15 μM.
Macrocephatriolides A and B (1 2), two novel guaiane-type sesquiterpene lactone trimers possessing unique linkage patterns, were identified from the whole plant of Ainsliaea macrocephala. The trimeric architecture 1 features a cyclohexene methylene bridge, which presumably constructed three constitutive monomers via Diels–Alder cycloaddition Michael addition, respectively. 2 tethered by 1,2-ethanediyl at same time. Their complex structures established extensive analysis spectroscopic data...