Abstract Purpose This study aimed to determine the efficacy of a multimodal deep learning (DL) model using optical coherence tomography (OCT) and angiography (OCTA) images for assessment choroidal neovascularization (CNV) in neovascular age‐related macular degeneration (AMD). Methods retrospective cross‐sectional was performed at multicentre, inclusion criteria were age >50 years diagnosis typical AMD. The OCT OCTA data an internal set two external sets collected. A DL developed with...

Background: Epiretinal membranes (ERM) have been found to be common among individuals >50 years old. However, the severity grading assessment for ERM based on optical coherence tomography (OCT) images has remained a challenge due lacking reliable and interpretable analysis methods. Thus, this study aimed develop two-stage deep learning (DL) system named iERM provide accurate automatic of clinical practice. Methods: The was trained human segmentation key features improve classification...

Benefiting from rich knowledge and the exceptional ability to understand text, large language models like ChatGPT have shown great potential in English clinical environments. However, performance of non-English settings, as well its reasoning, not been explored depth.

Abstract Purpose The progression of age‐related macular degeneration (AMD) is critical to treatment decisions in clinical practice. disease can be classified into four categories namely, drusen, inactive choroidal neovascularization (CNV), active CNV, and normal, according severity based on optical coherence tomography (OCT) images. Interpreting numerous OCT images still time‐consuming labor‐intensive, especially for the detection CNV activity. To address this problem, we developed a deep...

Abstract Background Pediatric uveitis may cause severe impairment of vision in children and affect their quality life as well cognitive ability. This study aims to evaluate the functional vision, visual-related health-related life, ability pediatric uveitis. Methods Children with aged 5–16 years old completed six validated instruments assess visual Cardiff Visual Ability Questionnaire for (CVAQC), vision-related Impact Vision Impairment (IVI-C), Quality Life Inventory (PedsQL), Chinese...

<h3>Purpose</h3> To evaluate the visual and anatomical outcomes of dexamethasone intravitreal implant (DXI; 700 μg, Ozurdex; Allergan, Irvine, California, USA) as adjunctive therapy for patients with refractory wet age-related macular degeneration (AMD). <h3>Methods</h3> Retrospective review medical records seven (seven eyes) who initially responded well to ranibizumab but subsequently developed persistent intra/sub-retinal fluid (IRF/SRF) underwent a single injection DXI, between May 2012...

<h3>Objective:</h3> The purpose of this study was to develop an algorithm incorporating MRI metrics classify patients with mild traumatic brain injury (mTBI) and controls. <h3>Methods:</h3> This institutional review board–approved, Health Insurance Portability Accountability Act–compliant prospective study. We recruited mTBI healthy controls through the emergency department general population. acquired data on a 3.0T Siemens Trio magnet including conventional imaging, resting-state fMRI,...

Abstract Purpose To predict the anti‐vascular endothelial growth factor (VEGF) therapeutic response of diabetic macular oedema (DME) patients from optical coherence tomography (OCT) at initiation stage treatment using a machine learning‐based self‐explainable system. Methods A total 712 DME were included and classified into poor good responder groups according to central thickness decrease after three consecutive injections. Machine learning models constructed make predictions based on...

Purpose: The structural changes measured by optical coherence tomography (OCT) are related to functional in visual fields (VFs). This study aims accurately assess the structure-function relationship and overcome challenges brought minimal measurable level (floor effect) of segmentation-dependent OCT measurements commonly used prior studies. Methods: We developed a deep learning model estimate performance directly from three-dimensional (3D) volumes compared it trained with two-dimensional...

To investigate the clinical features and cytochrome P450 family 4 subfamily V polypeptide 2 (CYP4V2) gene mutations in 14 Chinese families with Bietti crystalline dystrophy (BCD).Seventeen patients from unrelated BCD were recruited for complete ophthalmic examination genetic study. The 11 exons of CYP4V2 amplified genomic DNA all their members by polymerase chain reaction (PCR) then sequenced. Exons TIMP3 also sequenced patient associated choroidal neovascularization (CNV). One hundred...

Purpose . To investigate the prevalence and characteristics of focal choroidal excavation (FCE) concurrent with central serous chorioretinopathy (CSC) using multimodal imaging. Methods This was a retrospective single-institution study. Clinical features imaging findings were analyzed in eyes CSC FCEs, methods including optical coherence tomography (OCT), OCT angiography (OCTA), fluorescein (FA), indocyanine green (ICGA), fundus autofluorescence (FAF), multispectral Results Seventeen patients...

PURPOSE: To evaluate the uveal and capsular biocompatibility of intraocular lenses (IOLs) with a hydrophilic anterior surface hydrophobic posterior in rabbit model. SETTING: Eye Center, Affiliated Second Hospital, College Medicine, Zhejiang University, Hangzhou, China. METHODS: Modified silicone IOLs were produced by grafting 2-methacryloyloxyethyl phosphorylcholine (MPC) onto IOL using plasma technique. A contact-angle test characterized hydrophilicity surface; physical optical properties...

To develop a computer-aided diagnostic (CADx) system of age-related macular degeneration (AMD) through feature fusion between infrared reflectance (IR) and optical coherence tomography (OCT) modalities in order to explore the superiority multi-modality CADx optimal patterns inputs.This is dual center retrospective study. We retrospectively collected 2006 pairs IR OCT images algorithms. Two single-modality models three were constructed for comparison efficacy. The designed utilizing novel...

To identify the clinical characteristics, prognostic factors and visual outcomes in posterior segment IOFBs patients managed by PPV a tertiary hospital. A retrospective chart review was performed for 56 patients, who had removal between November 2013 2015. The mechanisms of injury, nature IOFBs, BCVA before after surgery, penetrating site complications surgery were all collected. Univariate analyses conducted to evaluate factors. mean age 36.4 years. mainly metal. Most injuries commonly...

Clinical application of artificial intelligence is limited due to the lack interpretability and expandability in complex clinical settings. We aimed develop an eye diseases screening system with improved based on a lesion-level dissection tested auxiliary ability system.The four-hierarchical interpretable (IEDSS) novel structural pattern named lesion atlas was developed identify 30 conditions using total 32,026 ultra-wide field images collected from Second Affiliated Hospital Zhejiang...

To compare the therapeutic effects of polysaccharide extract from Spirulina platensis (PSP) and amnion membrane (AME) on alkali burn-induced corneal neovascularization (CorNV).PSP AME were extracted dry powder human aminion respectively. Murine CorNV was induced by applying 1N sodiumhydroxide (NaOH) solution directly mice corneas. PSP extracts administered topically corneas 4 times daily for 7 days. The therapy evaluated using slit-lamp. At end therapy, harvested H&E staining, masson...

Biologics are increasingly used to treat Vogt-Koyanagi-Harada disease, but head-to-head comparisons with conventional immunosuppressants lacking. Here in this randomized trial (Chinese Clinical Trial Registry, ChiCTR2100043061), we assigned 110 patients (27 early-phase and 83 late-phase) cyclosporine-based immunosuppressant strategy (N = 56) or adalimumab-based biologic 54), each combined a modified corticosteroid regimen. The primary outcome is change from baseline best-corrected visual...