A5101458334- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Retinal and Optic Conditions
- Alzheimer's disease research and treatments
- Retinal Diseases and Treatments
- Dementia and Cognitive Impairment Research
- Sarcoidosis and Beryllium Toxicity Research
- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Vasculitis and related conditions
- Hepatitis B Virus Studies
- Cytomegalovirus and herpesvirus research
- Ocular Infections and Treatments
- interferon and immune responses
- Cholinesterase and Neurodegenerative Diseases
- Hepatitis C virus research
- Neuroscience and Neuropharmacology Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Healthcare and Venom Research
- Hypertrophic osteoarthropathy and related conditions
- Streptococcal Infections and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Breast Implant and Reconstruction
- Cutaneous lymphoproliferative disorders research
- Parvovirus B19 Infection Studies
Chongqing Medical University
2011-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2011-2025
National Clinical Research Center for Digestive Diseases
2023-2024
Guangdong Academy of Sciences
2024
Beijing Academy of Science and Technology
2024
Guangdong Institute of Intelligent Manufacturing
2024
Xuzhou Medical College
2023
Anhui Medical University
2022
First Affiliated Hospital of Anhui Medical University
2022
Beijing Municipal Ecological and Environmental Monitoring Center
2021
The tumor necrosis factor type 1 death receptor (TNFR1) contributes to apoptosis. TNFR1, a subgroup of the TNFR superfamily, contains cytoplasmic domain. We recently demonstrated that TNFR1 cascade is required for amyloid β protein (Aβ)–induced neuronal death. However, function in Aβ plaque pathology and precursor (APP) processing Alzheimer's disease (AD) remains unclear. report deletion gene APP23 transgenic mice (APP23/TNFR1−/−) inhibits generation diminishes formation brain. Genetic leads...
Elevated beta-secretase (beta-site amyloid precursor protein-cleaving enzyme 1 [BACE1]) activity has been found in the brains of patients with sporadic Alzheimer disease (AD) compared controls. Now we are particularly interested whether BACE1 can be identified cerebrospinal fluid (CSF) mild cognitive impairment (MCI), a population at high risk for AD. The possible presence CSF AD and MCI so far gone unreported.To examine MCI.We evaluated levels using 2 sandwich enzyme-linked immunosorbent...
The Apolipoprotein (ApoE) ε4 allele is a major genetic risk factor of Alzheimer's disease, and may affect the production amyloid beta (Aβ1–42). Recently, we have shown that β-secretase (BACE 1) activity can be reliably detected within brain human CSF. Here, examined an association between ApoE genotype CSF-levels BACE 1 in disease mild cognitive impairment (MCI). A total 148 subjects were included: 60 patients, 51 MCI 37 elderly healthy controls. Aβ1–42, protein measured all these subjects....
Purpose Systemic diseases are frequently associated with uveitis but often not recognised by clinicians. An estimate of the prevalence in a large-scale population is essential for understanding epidemiological profile and may be helpful clinical practice. Design A nationwide survey. Methods Data were obtained from national database which included registration cases 23 provinces, 5 autonomous regions 4 municipalities across mainland China. The primary outcome was identification systemic...
Increased preoperative red cell distribution width (RDW) is associated with poor prognosis in several cancers, but the relationships between RDW and changes (ΔRDW) colorectal cancer (CRC) remain unclear. Our study aimed to demonstrate prognostic significance of increased ΔRDW for CRC.In this retrospective analysis, we enrolled 833 patients who underwent CRC surgery 2015 2019 at Affiliated Hospital Xuzhou Medical University, China. our was defined as 1 month after discharge minus RDW....
The enzyme β-secretase (BACE1) is essentially involved in the production of cerebral amyloidogenic pathology Alzheimer's disease (AD). measurement BACE1 activity cerebrospinal fluid (CSF) has been reported, which may render CSF measureme
BACKGROUND Co-factor ACTR is frequently overexpressed and/or amplified in multiple types of tumors. The mechanism its function prostate cancer (CaP) still unclear. METHODS effects and androgen receptor (AR) depletion on cell proliferation gene expression their functions were analyzed a panel androgen-dependent -independent CaP cells CWR22 xenograft. RESULTS AR, but not TIF2, are required for cells, tumor growth. While AR inhibited the cyclin D1, B, cdc2, reduced E cdk2. In response to serum...
Although experimental studies support the hypothesis that exposure of infectious agents may trigger an aberrant immune response and contribute to noninfectious uveitis, association a definite pathogen with human uveitis conditions appears not have been well established in population.To evaluate associations tuberculosis infection risk several conditions.These mendelian randomization observational analyses were conducted genetic data Chinese cohort enrolled between April 2008 January 2018...
Objectives Corticosteroids remain the mainstay of treatment for rheumatic diseases but can cause hepatitis B virus (HBV) reactivation in patients with resolved HBV infection. Risk assessment and stratification are needed to guide management these before corticosteroid therapy. Methods We prospectively enrolled negative surface antigen positive Anti-hepatitis core status or without use determined exposure by calculating cumulative dose time-weighted average daily prednisone. The primary...
Vogt-Koyanagi-Harada (VKH) disease is a complex associated with multiple molecular immunological mechanisms. As the underlying mechanism for VKH unclear, we hope to utilize an integrated analysis of key pathways and drug targets develop novel therapeutic strategies.Candidate genes proteins involved in were identified through text-mining PubMed database. The GO KEGG pathway analyses used examine biological functions this disease. Molecule-related drugs predicted Drug-Gene Interaction Database...
Biologics are increasingly used to treat Vogt-Koyanagi-Harada disease, but head-to-head comparisons with conventional immunosuppressants lacking. Here in this randomized trial (Chinese Clinical Trial Registry, ChiCTR2100043061), we assigned 110 patients (27 early-phase and 83 late-phase) cyclosporine-based immunosuppressant strategy (N = 56) or adalimumab-based biologic 54), each combined a modified corticosteroid regimen. The primary outcome is change from baseline best-corrected visual...
Background/aims Fuchs’ uveitis syndrome (FUS) is one of the frequently misdiagnosed entities, which partly due to absence internationally recognised diagnostic criteria. This study was performed develop and evaluate a set revised criteria for FUS. Methods The clinical data Chinese patients with FUS non-FUS were collected analysed from tertiary referral centre between April 2008 December 2020. A total 593 625 northern China enrolled development Three hundred seventy-seven 503 southern used...
The performance of existing diagnostic criteria for Behçet's disease (BD) is usually evaluated by comparison with expert opinions, which may be limited misclassification and disagreement among experts. We aim to evaluate these in the absence a gold standard.We obtained two datasets involving possible BD other mimickers from uveitis registry using case-cohort nested case-control analyses, respectively. With Bayesian inference approach, sensitivity specificity International Study Group (ISG)...