Abstract Background Early detection of pancreatic ductal adenocarcinoma (PDAC) may improve the prognosis patients. This study was to identify metabolic features PDAC and discover early biomarkers for by tissue serum metabolomics analysis. Methods We conducted nontargeted analysis in samples 51 tumors, 40 noncancerous tissues (NT), 14 benign neoplasms (BP) as well from 80 patients with PDAC, 36 BP, 48 healthy controls (Ctr). The candidate metabolites identified initial were further quantified...

Pancreatic cancer (PC) is one of the most malignant cancers that develops rapidly and carries a poor prognosis. Synergistic therapy strategy could enhance clinical efficacy compared to either treatment alone. In this study, gold nanorods (AuNRs) were used as siRNA delivery vehicles interfere with oncogenes KRAS. addition, AuNRs anisotropic nanomaterials can absorb near-infrared (NIR) laser achieve rapid photothermal for cells. Modification erythrocyte membrane antibody Plectin-1 occurred on...

Background: Pancreatic cancer (PC) remains a difficult tumor to diagnose and treat. It is often diagnosed as advanced by reason of the anatomical structure deep retroperitoneal layer pancreas, lack typical symptoms effective screening methods detect this malignancy, resulting in low survival rate. Emodin (EMO) an economical natural product with treatment few side effects treatment. Magnetic nanoparticles (MNPs) can achieve multiplexed imaging targeted therapy loading wide range functional...

Background Serum high-density lipoprotein cholesterol (HDL-c) may influence cancer development. However, its relationship with the histological grade of pancreatic ductal adenocarcinoma (PDAC) is not well understood. This study aims to explore potential associations between serum HDL-c levels and different grades PDAC. Methods retrospective included 181 patients pathologically confirmed PDAC who underwent radical surgery. Clinical data, blood biochemical results, imaging features,...

Purpose: The purpose was to assess the predictive ability of computed tomography (CT) based radiomics signature in differential diagnosis between pancreatic adenosquamous carcinoma (PASC) and ductal adenocarcinoma (PDAC). Materials Methods: Eighty-one patients (63.6  8.8y) with PDAC 31 (64.7 11.1y) PASC who underwent preoperative CE-CT were included. A total 792 features extracted from late arterial phase (n=396) portal venous for each case. Significantly selected using Mann-Whitney U test,...

The novel coronavirus (COVID-19) has become a global pandemic outbreak. Patients with COVID-19 are prone to progress acute respiratory distress syndrome (ARDS), and even severe ARDS ineffective mechanical ventilation, an extremely high mortality. Extracorporeal membrane oxygenation (ECMO) provides effective support saves time for the treatment of COVID-19. present study reports that 31-year-old pregnant female infected by COVID-19, who suffered from fever, dyspnea, rapid ARDS. patient's...

Pancreatic ductal adenocarcinoma remains an extremely malignant tumor having a poor prognosis. The 5-year survival rate of PDAC is related to its stage (about 80% for I vs 20% other stages). However, detection in early difficult due the lack effective screening methods. In this study, we aimed construct novel metabolic model stage-I detection, using both serum and tissue samples.We employed untargeted technique, UHPLC-Q-TOF-MS, identify potential metabolite, then used targeted GC-TOF-MS,...

We aimed at investigating the effects of Dipeptidyl peptidase-4 (DPP-4) inhibitor saxagliptin (Saxa) on mouse acute lung injury (ALI)-induced by lipopolysaccharide (LPS) and potential mechanisms.Animals were divided into four groups: control, Saxa, LPS, LPS + Saxa. Histopathology changes tissues assessed hematoxylin eosin staining periodic acid-Schiff staining. The degree edema was determined wet/dry ratio. levels oxidative stress markers inflammatory cytokines in homogenate bronchoalveolar...

Both chronic mass-forming pancreatitis (CMFP) and pancreatic ductal adenocarcinoma (PDAC) are focal lesions share very similar clinical symptoms imaging performance. There is great value in preoperative differentiation of those two lesions. The purpose this study was to investigate the computed tomography (CT) features discriminating CMFP from PDAC.Forty-seven patients with pathologically confirmed PDAC 21 were included study. Demographic CT features, including tumor location, size, margin,...

Background: Pancreatic ductal adenocarcinoma (PDAC) develops rapidly and has a poor prognosis. It been demonstrated that pancreatic chronic pancreatitis (CP) have close connection. However, the underlying mechanisms for transforming into are still unclear. The purpose of this study was to identify real hub genes in development adenocarcinoma. Methods: RNA-seq data were downloaded from Gene Expression Omnibus (GEO) database. Weighted gene co-expression network analysis (WGCNA) performed...

Aim: Biomarker-targeted nanocarrier holds promise for early diagnosis and effective therapy of cancer. Materials & methods: This work successfully designs evaluates GPC1-targeted, gemcitabine (GEM)-loaded multifunctional gold near-infrared fluorescence (NIRF)/MRI targeted chemotherapy against pancreatic cancer in vitro vivo. Results: Blood biochemical histological analyses show that the vivo toxicity GPC1-GEM-nanoparticles (NPs) was negligible. Both studies demonstrate GPC1-GEM-NPs can be...

Intrapancreatic accessory spleen (IPAS) shares similar imaging findings with hypervascular pancreatic neuroendocrine tumors (PNETs), which may lead to unnecessary surgery.To investigate and compare the diagnostic performance of absolute apparent diffusion coefficient (ADC) normalized ADC (lesion-to-spleen ratios) in differential diagnosis IPAS from PNETs.A retrospective study consisting 29 patients (16 PNET vs 13 patients) who underwent preoperative contrast-enhanced magnetic resonance...

Abstract Immune checkpoint blockade (ICB) treatments have contributed to substantial clinical progress. However, challenges persist, including inefficient drug delivery and penetration into deep tumor areas, inadequate response ICB treatments, potential risk of inflammation due over‐activation immune cells uncontrolled release cytokines following immunotherapy. In response, this study, for the first time, presents a multimodal imaging‐guided organosilica nanomedicine (DCCGP)...

Photothermal Therapy In article 2302195, Zhaogang Teng, Wenli Qiu, Zhongqiu Wang, and co-workers develop a multimodal imaging-guided organosilica nanomedicine (DCCGP) for pancreatic cancer photoimmunotherapy. The innovative DCCGP platform combines fluorescence, magnetic resonance, real-time infrared photothermal imaging, improving diagnostic precision treatment effectiveness. By integrating stimulations with the PD-L1-induced ICB effect, it significantly enhances tumor cell elimination,...

To assess the performance of high-resolution computed tomography (HRCT) in discriminating consolidation pattern pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma from lobar pneumonia.This retrospective study comprised 26 patients with pathologically confirmed MALT (12 men and 14 women; mean age, 59.4±12.1 years) 36 pneumonia by body fluids or respiratory secretion culture (16 20 41.8±26.3 years). Two radiologists independently evaluated CT images. The effectiveness these variables...

Objective: Intraductal papillary mucinous neoplasm (IPMN) is a rare pancreatic lesion. The identification of malignancy critical for the establishment treatment strategies. Main duct (MPD) diameter one feature malignant IPMNs. However, threshold 1.0 cm challenged. In this study, we explored independent risk factors and further calculated MPD in identifying Method: A total 151 IPMN patients were included retrospective study. Demographic information, clinicopathological features, laboratory...

Diagnosis of pancreatic ductal adenocarcinoma (PDAC) is difficult due to the lack specific symptoms and screening methods. Only less than 10% PDAC patients are candidates for surgery at time diagnosis. Thus, there a great global unmet need valuable biomarkers that could improve opportunity detect resectable stage. This study aimed develop potential biomarker model detection by tissue serum metabolomics.Ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry...