A5009879012- Toxoplasma gondii Research Studies
- Trace Elements in Health
- Parasitic Infections and Diagnostics
- Heavy Metal Exposure and Toxicity
- Ferroptosis and cancer prognosis
- Viral Infections and Immunology Research
- Cancer-related molecular mechanisms research
- Glutathione Transferases and Polymorphisms
- Circular RNAs in diseases
- Cytomegalovirus and herpesvirus research
- Selenium in Biological Systems
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Immune Response and Inflammation
- Immune cells in cancer
- Vascular Malformations Diagnosis and Treatment
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Platelet Disorders and Treatments
- Immune Cell Function and Interaction
- Intracerebral and Subarachnoid Hemorrhage Research
Anhui Medical University
2011-2023
First Affiliated Hospital of Anhui Medical University
2018
Shanghai Institute of Hematology
2018
XinHua Hospital
2018
Iron is a trace metal element that essential for the survival of cells and parasites. The role iron in cerebral toxoplasmosis (CT) still unclear. Deferiprone (DFP) orally active chelator binds molar ratio 3:1 (ligand:iron) promotes urinary excretion to remove excess from body. aims this experiment were observe alterations brains with Toxoplasma gondii (T. gondii) acute infections investigate mechanism ferroptosis CT using DFP. We established model vivo TgCtwh3, dominant strains which are...
Zrt/Irt-like protein 8 (ZIP8) (encoded by Slc39a8) is a multifunctional membrane transporter that influxes essential metal cations Zn
Toxoplasma gondii infections are prevalent in a wide range of mammalian hosts including humans. Infection pregnant women may cause the transmission parasite to fetus that makes serious problems. IgM antibodies against (Toxo-IgM) have been believed be significant indicators for both recently acquired and congenital toxoplasmosis. So far, however, there has not any recognized protein T. specifically reacts antibodies. Here, an antigen exclusively detection screened by two-dimensional...
Infantile hemangioma (IH) is a common and benign vascular neoplasms, which has high incidence in children. Although IH benign, some patients experience complications such as pain, functional impairment, permanent disfigurement. Treatment options for include corticosteroids, surgery, vincristine, interferon or cyclophosphamide. However, none of these modalities are ideal due to restrictions potential serious side effects. There thus great need explore novel treatments with less Angiogenesis,...
Ocular toxoplasmosis (OT) is one of the most common causes posterior uveitis. However, pathogenic mechanisms OT have not been well elucidated. Here, we used C57BL/6 (B6) mice to establish by peroral infection with 20 cysts TgCtWh6 strain, and severe ocular damage was observed histopathological analysis in eyes infected mice. RNA-sequencing results showed that T . gondii increased expression NK-mediated cytotoxicity gene pathway at Day 30 after infection. Both NK-cell CD49a + subsets are...
Toxoplasma gondii (T. gondii), as an intracellular protozoan parasite, has the potential to disturb homeostasis of trace metal elements in host cells. Zinc (Zn) is one those essential metals that required for combating infection. cellular controlled by zinc membrane transporters, including efflux and influx transporters. One Zrt-Irt-like protein (ZIP) ZIP8, facilitates into cytosol. It was recently reported play significant roles facilitating Zn uptakes during Here, we investigated function...
Toxoplasma gondii (T. gondii) reactivation is common, especially among immunocompromised individuals, such as AIDS patients. The cardiac involvement associated with toxoplasmosis, however, usually obscured by neurological deterioration. aim of this study was to observe the alterations in functions various landmark periods after infection and assess whether more seriously damages heart.We established three models mice using TgCtwh6, a major strain T. prevalent China. groups included an acute...
Abstract BACKGROUND Gastric cancer (GC) is one of the most common malignant cancers, with high morbidity and mortality rates worldwide. The present study was to explore whether miR-200b a tumor suppressor in GC unveil potential mechanisms.METHODS Levels c-Myc, Cyclin D1, MMP-3 MMP-9 expression were detected respectively by q-PCR Western blot assay. BrdU proliferation assay, Cell cycle analysis Wound-healing used role inhibitor, mimics or ZEB1-RNAi TGF-β1-treated SGC-7901/DDP cells.RESULTS...
Abstract Background: There is increasing evidence that tumor-associated macrophages play an important role in the development of tumors. The more macrophages, faster tumors develop. On one hand, studies have shown dense granule protein molecule Toxoplasma gondii (ToxoGRA15II) tends to induce differentiation classically activated (M1). GRA15II can also M2 reversal polarized M1. Promote occurrence Th1 immune response.Methods: Here, we constructed LV-gra15Ⅱ, which was transferred M1-like and/or...