A5081368329- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Regulation of Appetite and Obesity
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Biochemical Analysis and Sensing Techniques
- Neuroscience and Neuropharmacology Research
- Advanced Causal Inference Techniques
- Statistical Methods and Inference
- Cerebrospinal fluid and hydrocephalus
- Neurotransmitter Receptor Influence on Behavior
- Health Systems, Economic Evaluations, Quality of Life
- Adipose Tissue and Metabolism
- Autoimmune Neurological Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Diet and metabolism studies
- Neonatal and fetal brain pathology
- Receptor Mechanisms and Signaling
- Veterinary Equine Medical Research
- Neuropeptides and Animal Physiology
- Neuroscience of respiration and sleep
- Memory and Neural Mechanisms
- Genetics and Neurodevelopmental Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Diabetes Management and Research
Sage Therapeutics (United States)
2024-2025
Duke University
2018-2024
Waitemata District Health Board
2024
Duke Medical Center
2019-2020
Duke University Hospital
2020
University of Virginia
2014-2018
Winston-Salem State University
2018
Pennsylvania State University
2011-2014
Michigan State University
2011
Stony Brook University
2010
GIPR activity in α cells is required for the complete metabolic response to a meal.
The blood-brain barrier (BBB) regulates the entry of substrates and peptides into brain. Ghrelin is mainly produced in stomach but exerts its actions central nervous system (CNS) by crossing BBB. Once present CNS, ghrelin can act hypothalamus to regulate food intake, hippocampus neurogenesis, olfactory bulb food-seeking behavior. goal this study was determine whether primary signaling receptor for ghrelin, growth hormone secretagogue (GHSR), mediates transport from blood brain.We utilized...
In humans, drug-associated stimuli can provoke heroin relapse during abstinence. rats, cues paired with self-administration reinstate seeking in a model. The neurobiological mechanisms involved this reinstatement, however, are largely unknown. Here, we determined the effect of LY379268, an mGluR2/3 agonist that decreases evoked glutamate release, on cue-induced reinstatement seeking. Systemic injections LY379268 attenuated induced by exposure to discrete tone-light cue was previously...
Abstract We aimed to characterize the cognitive profile of post-acute COVID-19 syndrome (PACS) patients with complaints, exploring influence biological and psychological factors. Participants confirmed SARS-CoV-2 infection complaints ≥ 8 weeks phase were included. A comprehensive neuropsychological battery (NPS) health questionnaires administered at inclusion 1, 3 6 months. Blood samples collected each visit, MRI scan baseline months, and, optionally, cerebrospinal fluid. Cognitive features...
Projections of the incidence and prevalence disease are important for public health planning. This paper describes methods projecting a chronic in ageing populations. The approach uses age-specific rates together with assumptions about survival to reconstruct prevalence. can be used evaluate potential impact interventions that may prevent or prolong survival. We project future Alzheimer's United States. found will nearly quadruple over next 50 years. Although projections absolute sensitive...
Insulin affects multiple important central nervous system (CNS) functions including memory and appetite, yet the pathway(s) by which insulin reaches brain interstitial fluid (bISF) has not been clarified. Recent studies demonstrate that to reach bISF, subarachnoid cerebrospinal (CSF) courses through Virchow-Robin space (VRS) sheaths penetrating pial vessels down capillary level. Whether predominantly enters VRS bISF local transport blood-brain barrier, or being secreted into CSF choroid...
The Direct Assessment of Functional Abilities (DAFA) was designed as a direct measure instrumental activities daily living (IADLs) that could be compared with an indirect assessment IADLs by the Pfeffer Activities Questionnaire (PFAQ). DAFA (28 demented and 15 control subjects) PFAQ (subjects informants) were administered twice, together brief cognitive battery. Demented subjects performed significantly worse on than predicted self-report (PFAQ), overestimation abilities increased severity...
A major problem in treating obesity is high rates of relapse to maladaptive food-taking habits during dieting. This often provoked by acute re-exposure palatable food, food-associated cues, or stress. We used a reinstatement model, commonly study abused drugs, explore the effect peptide YY3-36 (PYY3-36) on high-fat (35%, 45 mg pellets) food seeking induced exposure pellets (pellet priming), cue previously associated with pellet delivery cue), yohimbine (2 mg/kg, pharmacological stressor)....
The insulinotropic actions of glucagon-like peptide 1 receptor (GLP-1R) in β-cells have made it a useful target to manage type 2 diabetes. Metabolic stress reduces β-cell sensitivity GLP-1, yet the underlying mechanisms are unknown. We hypothesized that Glp1r expression is heterogeneous among and metabolic decreases number GLP-1R-positive β-cells. Here, analyses publicly available single-cell RNA-Seq sequencing (scRNASeq) data from mouse human indicated significant populations do not express...
Abstract Context Glucagon-like peptide 1 (GLP-1), an insulinotropic released into the circulation from intestinal enteroendocrine cells, is considered a hormonal mediator of insulin secretion. However, physiological actions circulating GLP-1 have been questioned because short half-life active peptide. Moreover, there mounting evidence for localized, intra-islet mediation receptor (GLP-1r) signaling including role islet dipeptidyl-peptidase 4 (DPP4). Objective To determine whether GLP-1r...
Background: There is evidence for dysregulated cholesterol homeostasis in Huntington’s disease (HD). The brain-specific metabolite 24(S)-hydroxycholesterol (24(S)-OHC) decreased manifest HD. 24(S)-OHC an endogenous positive allosteric modulator (PAM) of the N-methyl-D-aspartate (NMDA) receptor, suggesting lower may contribute to NMDA receptor hypofunction We hypothesized changes would be associated with cognitive impairment early Objective: To determine interactions between oxysterols...
Glucagon is generally defined as a counterregulatory hormone with primary role to raise blood glucose concentrations by increasing endogenous production (EGP) in response hypoglycemia. However, glucagon has long been known stimulate insulin release, and recent preclinical findings have supported paracrine action of directly on islet β-cells that augments their secretion. In mice, the insulinotropic effect dependent not present during basal euglycemia. To test hypothesis relative effects...
Emerging evidence supports the importance of ghrelin to defend against starvation-induced hypoglycemia. This effect may be mediated by inhibition glucose-stimulated insulin secretion as well reduced sensitivity. However, administration during meal consumption also stimulates release glucagon-like peptide 1 (GLP-1), an incretin important in nutrient disposition. The objective this study was evaluate interaction between and GLP-1 on parameters glucose tolerance following a mixed-nutrient meal....