A5016900598- Genetics, Aging, and Longevity in Model Organisms
- Genetic Mapping and Diversity in Plants and Animals
- Physiological and biochemical adaptations
- Medicinal Plants and Neuroprotection
- Phytochemicals and Antioxidant Activities
- Genetic diversity and population structure
- Evolution and Genetic Dynamics
- Medicinal Plants and Bioactive Compounds
- Retinal Diseases and Treatments
- Antioxidant Activity and Oxidative Stress
- COVID-19 and Mental Health
- Diet and metabolism studies
- Neurobiology and Insect Physiology Research
- Intensive Care Unit Cognitive Disorders
- Nutrition, Genetics, and Disease
- Long-Term Effects of COVID-19
- Animal Behavior and Reproduction
- Complementary and Alternative Medicine Studies
- Circadian rhythm and melatonin
- melanin and skin pigmentation
- Botanical Studies and Applications
- Neurological Disease Mechanisms and Treatments
- Demographic Trends and Gender Preferences
- Health and Conflict Studies
- Retinoids in leukemia and cellular processes
Sage Therapeutics (United States)
2023-2024
Tufts University
2019-2021
University of California, Irvine
2014-2021
Jean Mayer Human Nutrition Research Center on Aging
2021
Agricultural Research Service
2020
Wellcome Sanger Institute
2020
Scripps Memorial Hospital
2020
Scripps Clinic
2020
Scripps Health
2020
Abstract We aimed to characterize the cognitive profile of post-acute COVID-19 syndrome (PACS) patients with complaints, exploring influence biological and psychological factors. Participants confirmed SARS-CoV-2 infection complaints ≥ 8 weeks phase were included. A comprehensive neuropsychological battery (NPS) health questionnaires administered at inclusion 1, 3 6 months. Blood samples collected each visit, MRI scan baseline months, and, optionally, cerebrospinal fluid. Cognitive features...
Laboratory selection experiments are alluring in their simplicity, power, and ability to inform us about how evolution works. A longstanding challenge facing with metazoans is that significant generational turnover takes a long time. In this work, we present data from unique system of experimentally evolved laboratory populations Drosophila melanogaster have experienced three distinct life-history regimes. The goal our study was determine quickly certain regime diverge phenotypically...
Berry fruits contain a variety of bioactive polyphenolic compounds that exhibit potent antioxidant and anti-inflammatory activities.
Blueberries (BB) contain an array of bioactive phenolic compounds that may play a protective role against various age-related diseases. Here we explored the metabolic fate BB phenolics and their relationship to cognitive function after chronic (90 days) supplementation freeze-dried (24 g d-1, equivalent 1 cup fresh BB) or control in randomized, double-blind, parallel study with 38 healthy older adults (60-75 years). Blood samples were collected at fasting (t = 0 h) 2 h breakfast meal on days...
Functional changes in the brain during ageing can alter learning and memory, gait balance - some cases leading to early cognitive decline, disability or injurious falls among older adults. Dietary interventions with strawberry (SB) have been associated improvements neuronal, psychomotor functions rodent models of ageing. We hypothesised that dietary supplementation SB would improve mobility cognition In this study, twenty-two men fifteen women, between ages 60 75 years, were recruited into a...
Studies combining experimental evolution and next-generation sequencing have found that adaptation in sexually reproducing populations is primarily fueled by standing genetic variation. Consequently, the response to selection rapid highly repeatable across replicate populations. Some studies suggest at both phenotypic genomic levels, evolutionary history has little impact. Other even when phenotypically, can significant impacts level. Here we test two hypotheses may explain this discrepancy....
In experimental evolution, we impose functional demands on laboratory populations of model organisms using selection. After enough generations such selection, the resulting constitute excellent material for physiological research. An intense selection regime increased starvation resistance was imposed 10 large outbred Drosophila populations. We observed responses and desiccation resistance, metabolic reserves, heart robustness via electrical pacing. Furthermore, sequenced pooled genomes...
Healthspan science aims to add healthy, functional years human life. Many different methods of improving healthspan have been investigated, chiefly focusing on just one aspect an organism's health such as survival. Studies in Drosophila melanogaster demonstrated that a reversal long-abandoned ancestral diet results improved health, particularly at later ages. Meanwhile, pharmaceutical studies botanical extracts potent antiaging properties, capable extending the mean lifespan D. by up 25%,...
Our intuitive understanding of adaptation by natural selection is dominated the power at early ages in large populations. Yet, as forces fall with adult age, we expect to be attenuated age. Explicit simulations age-dependent suggest that populations adapt a novel environment quickly ages, but only slowly and incompletely later ages. Experimental tests for diet were performed on Drosophila melanogaster. The results support prediction should perform better an ancestral, long-abandoned diet,...
Abstract A collection of forty populations were used to study the phenotypic adaptation Drosophila melanogaster larvae urea‐laced food. long‐term goal this research is map genes responsible for these phenotypes. This mapping requires large numbers populations. Thus, we studied fifteen subjected direct selection urea tolerance and five controls. In addition, another twenty which had not been exposed but stress or demographic selection. study, describe differentiation in population six...
While solutions to major scientific and medical problems are never perfect or complete, it is still reasonable delineate cases where both have been essentially solved. For example, Darwin’s theory of natural selection provides a successful solution the problem biological adaptation, while germ infection solved contagious disease. Likewise in context medicine, we effectively disease, reducing minor cause death disability for almost everyone countries with advanced medicine adequate resources....
Abstract Background Offspring of parent(s) with age-related macular degeneration (AMD) have a 45% lifetime risk developing the disease. High foveal pigment optical density (MPOD) is protective, whereas individuals “foveal dip” (FMPD) are at increased risk. Shortage dietary carotenoids lutein, zeaxanthin as well fish consumption reported AMD factors. This Early Biomarkers (EBAMD) study evaluates serum factors that protect MPOD architecture in Caucasian offspring AMD. Methods N = 130 subjects...
Author(s): Rutledge, Grant Allen | Advisor(s): Rose, Michael R Abstract: The search for a diet or supplement that improves healthspan in humans has been daunting. This dissertation applies theory on the evolution of aging to understand what diets are best extending healthspan. Chapter 1 reviews strategies extension using and supplementation from standpoint evolutionary biology. Then it introduces new strategy dietary enhancement Our intuitive understanding adaptation by natural selection is...
Research suggests that supplementation with berries may improve cognition during aging. In two recently published 90-day trials, healthy older adults (ages 60–75; BMI 18.5–29.9) who consumed 24 g/d freeze-dried blueberry or strawberry showed improved cognitive function, relative to placebo controls. However, the mechanism of action underlying these benefits and role berry phenolics in enhancement is not fully understood. this study, we hypothesized dietary would increase concentrations...
Abstract We aimed to characterize the cognitive profile of post-acute COVID-19 syndrome (PACS) patients with complaints, exploring influence biological and psychological factors. Participants confirmed SARS-CoV-2 infection complaints ≥ eight weeks phase were included. A comprehensive neuropsychological battery (NPS) health questionnaires administered at inclusion 1, 3 6 months. Blood samples collected each visit, MRI scan baseline months, and, optionally, cerebrospinal fluid. Cognitive...