A5107205588- Physiological and biochemical adaptations
- Neurobiology and Insect Physiology Research
- Genetics, Aging, and Longevity in Model Organisms
- Insect and Arachnid Ecology and Behavior
- Insect Resistance and Genetics
- Environmental Toxicology and Ecotoxicology
- Mitochondrial Function and Pathology
- Spaceflight effects on biology
- Insect-Plant Interactions and Control
- Reinforcement Learning in Robotics
- Aluminum toxicity and tolerance in plants and animals
- Microbial metabolism and enzyme function
- Genetic diversity and population structure
- Ion Transport and Channel Regulation
- Artificial Intelligence in Games
- Photoreceptor and optogenetics research
- Muscle metabolism and nutrition
- Insect behavior and control techniques
- Animal Behavior and Reproduction
- Antiplatelet Therapy and Cardiovascular Diseases
- Plant and Biological Electrophysiology Studies
- Plant and animal studies
- Barrier Structure and Function Studies
- Advanced Malware Detection Techniques
- High Altitude and Hypoxia
ETH Zurich
2024
University of California, Irvine
2006-2023
University of Zurich
2021-2023
Zürich Airport (Switzerland)
2022
Peter MacCallum Cancer Centre
1982-1984
Yeshiva University
1979
Albert Einstein College of Medicine
1979
University of Strathclyde
1965-1968
Methanol synthesized from captured greenhouse gases is an emerging renewable feedstock with great potential for bioproduction. Recent research has raised the prospect of methanol bioconversion to value-added products using synthetic methylotrophic
Abstract A transgenic system (“FLP-out”) based on yeast FLP recombinase allowed induced overexpression of MnSOD enzyme in adult Drosophila melanogaster. With FLP-out a brief heat pulse (HP) young, flies triggered the rearrangement and subsequent expression transgene throughout life span. Control (no HP) overexpressing had identical genetic backgrounds. The amount achieved varied among six independent lines, with increases up to 75%. Life span was increased proportion increase enzyme. Mean by...
Abstract Background Several interventions increase lifespan in model organisms, including reduced insulin/insulin-like growth factor-like signaling (IIS), FOXO transcription factor activation, dietary restriction, and superoxide dismutase (SOD) over-expression. One question is whether these manipulations function through different mechanisms, or they intersect on common processes affecting aging. Results A doxycycline-regulated system was used to over-express manganese-SOD (MnSOD) adult...
The 'rate of living' theory predicts that longevity should be inversely correlated with the rate mitochondrial respiration. However, recent studies in a number model organisms, including mice, have reported interventions retard aging process are, fact, associated an increase activity. To better understand relationship between energy metabolism and longevity, we supplemented endogenous respiratory chain machinery fruit fly Drosophila melanogaster alternative single-subunit NADH-ubiquinone...
We describe for the first time changes in rate of CO2 release (as a surrogate metabolic rate) terminal larval stage insect Rhodnius prolixus following blood meal and during molt leading to adult stage. These data are presented on whole‐animal basis as well per gram wet dry weight. have also used techniques that allow us actual body tissue (i.e., removing weight remaining bloodmeal gut metabolically inactive portion cuticle). While whole animal rises approximately 10‐fold 15 d feeding, mass...
Insects display an array of respiratory behaviors, including the use discontinuous gas exchange. This pattern is characterized by periods spiracular closure, micro-openings (flutter), and complete openings during which majority exchange takes place. A current model insect control suggests that spiracles are controlled two interacting feedback loops, produce pattern. The flutter period thought to be initiated a critically low partial pressure oxygen, while open high CO2 threshold. goal our...
Microgravity acts on cellular systems several levels. Cells of the immune system especially react rapidly to changes in gravity. In this study, we performed a correlative metabolomics analysis short-term and long-term microgravity effects primary human macrophages. We could detect an increased amino acid concentration after five minutes altered gravity, that was inverted 11 days microgravity. The acids reacted most gravity were tightly clustered. observed indicated protein degradation...
ABSTRACT The Malpighian tubules of Rhodnius prolixus are divided into two regions; the upper tubule, which is site isosmotic secretion and haemolymph filtration, lower tubule where water KC1 resorbed. In microvilli arranged in clumps consisting several hundred lying closely parallel. microvillar plasma membranes do not touch but held ≈l6nm apart along full length microvilli. As a consequence, extracellular space between consists long narrow channels. A morphometric analysis extracellular,...
The ion-transporting epithelia of insects possess some unusual morphological adaptations which promote close juxtaposition mitochondria and the plasma membranes. A particularly striking example this adaptation is provided by movement branches into out apical microvilli in Malpighian tubules. In hemipteran Rhodmus prohxus, resorptive lower tubule are small contain no during non-transporting period. When ion transport stimulated,either vivo or vitro, there a concomitant growth microvillar...
The germination of Bacillus subtilis spores in stationary aerobic culture is inhibited by p-chloro-m-cresol. Spores this way can be recovered and induced to germinate the addition stabilized cultures non-ionic surfactant, polysorbate (Tween) 80. In stabilization process inhibitor may reversed after periods up 21 hours. interfere with an enzymatic lytic activity responsible for initiation. A denaturation not indicated.
ABSTRACT In this study, we demonstrate that two of the osmolytes utilized in osmoconforming strategy larval Culex tarsalis are regulated by fundamentally different signals. When external osmolality was increased using salinity (sea salts), hemolymph NaCl, proline and trehalose concentrations significantly. sorbitol used to increase without an elevation salt concentration, NaCl decreased, whereas concentration increased. The results suggest accumulation cued increases salinity, levels...
The paper featured in this JEB Classics article(Phillips, 1964c) is one of a trio articles Volume 41 Journal Experimental Biologyin which John Phillips examines the issue active transport insect rectum (Phillips, 1964a,b,c). insects highly aerobically organ. Active transport,that coupling metabolic energy to movement compounds across epithelium, vital for osmoregulation and retention ions,water nutrients. paper, entitled `Rectal absorption desert locust, Schistocerca gregaria Forskal. III....
The transcriptome of human immune cells rapidly reacts to altered gravity in a highly dynamic way. We could show previous experiments that transcriptional patterns profound adaption after seconds minutes gravity. To gain further insight into these alteration and dynamics, we conducted standardized RNA-Seq experiment with Jurkat T exposed 9xg hypergravity for 3 15 min, respectively. investigated the frequency which individual exons were used during transcription discovered differential exon...