A5003532193- Thyroid and Parathyroid Surgery
- Thyroid Cancer Diagnosis and Treatment
- Voice and Speech Disorders
- Parathyroid Disorders and Treatments
- Tracheal and airway disorders
- Immune Response and Inflammation
- Neuroendocrine Tumor Research Advances
- Head and Neck Anomalies
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Thyroid Disorders and Treatments
- Immune Cell Function and Interaction
- Airway Management and Intubation Techniques
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Topic Modeling
- Cytokine Signaling Pathways and Interactions
- Head and Neck Cancer Studies
- Thermal Regulation in Medicine
- BRCA gene mutations in cancer
- Gastrointestinal Tumor Research and Treatment
- Clostridium difficile and Clostridium perfringens research
- Adolescent Sexual and Reproductive Health
- Autoimmune and Inflammatory Disorders Research
- Biomedical Text Mining and Ontologies
Queen Mary Hospital
2015-2025
University of Hong Kong
2015-2025
Chinese University of Hong Kong
2022-2025
King's College London
2014
San Francisco Department of Public Health
2006
University of Calgary
2004
Hong Kong Baptist University
1997
Australian National University
1984
Objectives: Cytologically indeterminate thyroid nodules (Bethesda class III or IV) carry a 10-40% risk of malignancy. Diagnostic lobectomies are frequently performed but negative surgeries incur unnecessary costs on the healthcare system, potential complications, and impacts quality life. Molecular tests (MTs) have been developed to reduce surgeries. However, well-validated, high-performance MTs often expensive, their cost-effectiveness has not studied in Asian population. This study...
We developed a named entity (NE) framework for information extraction from semi-structured clinical notes retrieved The Cancer Genome Atlas-Thyroid (TCGA-THCA) database and examined Large Language Models (LLMs) strategies to classify the 8th edition of American Joint Committee on (AJCC) staging Thyroid Association (ATA) risk category patients with well-differentiated thyroid cancer. NE consisted annotation guidelines development, ground truth labelling, prompting approaches, evaluation...
Tumor microenvironment (TME) remodeling plays a pivotal role in thyroid cancer progression, yet its spatial dynamics remain unclear. In this study, we integrate transcriptomics and single-cell RNA sequencing to map the TME architecture across para-tumor (PT) tissue, papillary (PTC), locally advanced PTC (LPTC), anaplastic carcinoma (ATC). Our integrative analysis reveals extensive molecular cellular heterogeneity during enabling identification of three distinct thyrocyte meta-clusters,...
AimsThe present study was designed to (a) examine the interrelationship between endothelial function and CRP in healthy individuals (b) evaluate relationship of each biomarker towards global Framingham risk scores.
Graves' disease (GD) is the most common cause of hyperthyroidism. Antithyroid drugs (ATDs) are first-line treatment, but when discontinued, >50% patients experience relapses. Conventional definitive treatment options include surgery and radioiodine therapy (RAI), each with its own disadvantages. Radiofrequency ablation (RFA) achieved promising short-term remission rates in a previous pilot study. The current study reports our using RFA to treat relapsed GD largest cohort longer follow-up period.
Thyroid dysfunction, including thyroiditis, is well recognized in COVID-19 patients. We evaluated thyroid ultrasonographic features among survivors, which are less known. Adult survivors without known disorders who attended dedicated clinic underwent ultrasonography and assessment of function autoimmunity. Adults admitted for acute non-thyroidal surgical problems negative were recruited as control. SARS-CoV-2 viral load (VL) was presented the inverse cycle threshold values from real-time...
SUMMARY Complement C5a is aetiologically linked to inflammatory tissue damage in conditions like septicaemia, immune complex diseases and ischaemia-reperfusion injury. We here describe a monoclonal antibody (mAb), 137–26, that binds the moiety of human C5 neutralizes effects without interfering with cleavage subsequent formation lytic C5b-9 complex. Mouse anti-human mAbs were generated reactivity was detected by ELISA surface plasmon resonance. The inhibition binding receptor studied using...
The coexistence of insulinoma and type 2 diabetes is rare the diagnostic process often challenging. Continuous glucose monitoring system devices, which are more readily available nowadays, provide a useful tool for diagnosis evaluation treatment response. Curative surgery mainstay insulinoma. Here, we report Chinese patient with diagnosed simultaneously diabetes. His was managed endoscopic ultrasound guided-radiofrequency ablation (EUS-RFA) achieved complete resolution hypoglycaemic...
Recognition of the therapeutic value glucocorticosteroids in treatment inflammation has preceded awareness mechanism(s) action these drugs. We recently showed that coculture human T84 epithelial monolayers for 2 days with anti-CD3 activated peripheral blood mononuclear cells (A-PBM) led to impaired ion transport responses and reduced barrier function. tested hypothesis budesonide, as a member new generation more topically selective steroids, could prevent immune-mediated abnormalities....
Revascularisation of transplanted islets is an essential prerequisite for graft survival and function. However, current islet isolation procedures deprive the endothelial tubulets. This may have a detrimental effect on revascularisation process following transplantation. We hypothesise that modification procedure preserves vessels improve Here, we present modified method by which substantial amount cells still attached to could be preserved. The with preserved isolated this were...
We previously showed that higher SARS-CoV-2 viral load correlated with smaller thyroid volumes among COVID-19 survivors at 2 months after acute COVID-19. Our current follow-up study evaluated the evolution of and thyroiditis features within same group patients 6 later.Adult who underwent ultrasonography infection (USG1) were recruited for USG later (USG2). The primary outcome was change in volume. also reassessed on USG, function anti-thyroid antibodies.Fifty-four (mean age 48.1 years; 63%...