A5018252645- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Redox biology and oxidative stress
- Inflammasome and immune disorders
- Nitric Oxide and Endothelin Effects
- Mitochondrial Function and Pathology
- Aortic Disease and Treatment Approaches
- Nanopore and Nanochannel Transport Studies
- Mycobacterium research and diagnosis
- Gout, Hyperuricemia, Uric Acid
- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Microfluidic and Capillary Electrophoresis Applications
- Atherosclerosis and Cardiovascular Diseases
- Heat shock proteins research
- Aortic aneurysm repair treatments
- Streptococcal Infections and Treatments
- Sleep and Wakefulness Research
- Fuel Cells and Related Materials
- Neurological Disease Mechanisms and Treatments
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
Guangzhou Medical University
2022-2024
Renji Hospital
2022
Shanghai Jiao Tong University
2022
Guangzhou Women and Children Medical Center
2022
The First Affiliated Hospital, Sun Yat-sen University
2017-2019
Sun Yat-sen University
2017-2019
Yale University
2018-2019
Institute of High Energy Physics
2015
Chinese Academy of Sciences
2015
Abdominal aortic aneurysm (AAA) is a catastrophic disease with little effective therapy, likely due to the limited understanding of mechanisms underlying AAA development and progression. ATF3 (activating transcription factor 3) has been increasingly recognized as key regulator cardiovascular diseases. However, role in progression remains elusive.
We have developed a nanopore sensing approach for the selective detection of 8-oxo-2′-deoxyguanosine (8-oxoG) in single-stranded DNA. First, 1,12-dodecanediamine is coupled with 8-oxoG-containing DNA molecules high yield which leaves free amine group subsequent attaching an adamantane moiety. After incubation cucurbit[7]uril, host–guest complex-modified hybrid translocated through α-hemolysin nanopore. Highly characteristic events can be recorded and used to quantify 8-oxoG-DNA content...
Objective: AIP1 expression is downregulated in human atherosclerotic plaques and global deletion of mice exacerbates atherosclerosis ApoE-KO mouse models. However, the direct role endothelium, vascular remodeling associated diseases has not been determined. Approach Results: We used endothelial cell (EC)-specific AIP1-deficient (AIP1-ECKO) to define intima-media thickening a carotid artery ligation model characterized by both neointimal hyperplasia inward vessel remodeling. Compared WT...
Objective: Mitochondrial thioredoxin 2 (Trx2) is a vital mitochondrial redox protein that mediates normal thiol reduction and provides electrons to peroxiredoxin 3 (Prx3) scavenge H2O2 in mitochondria. It has been widely reported Trx2 deletion cells or mice generates massive reactive oxygen species (ROS) which have implicated many pathological processes. On the contrary, how ROS regulate expression activity remains be elucidated. Approach Results: Here we show excess induce endothelial cell...
Abstract Background: Serrated polyps (SP) is associated with an increased risk of colorectal cancer. Patients SP history tend to have recurrence. However, the factors for metachronous (MP) in those patients are not well established. Methods: Data colonoscopy were retrospectively reviewed from October 2012 2021. The pathology database, electronic medical records and telephone follow-up data also observed. Results: A total 906 studied which consisted 278 MPs 628 without. Multiplicity (OR...
Oxidative stress-induced inflammation is a major pathogenic mechanism in sepsis-associated encephalopathy (SAE). We hypothesized that regulation of reactive oxygen species (ROS) by the neuropeptide orexin-A could prevent SAE-induced oxidative stress and inflammation. Therefore, aim this study was to investigate effects on SAE mice.
Abstract Dysregulated inflammation is closely associated with increased mortality in sepsis. Platelets have emerged as key inflammatory cells implicated the pathology of sepsis, including development thrombosis, thrombocytopenia, and neutrophil extracellular traps (NETs). Platelet’s contributions to rapid clinical deterioration dysregulated sepsis not been defined. In our cohort, incidence thrombocytopathy excessive cytokines released patients severe were significantly increased. Platelet...