A5042706037- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Nanocluster Synthesis and Applications
- Alzheimer's disease research and treatments
- Molecular Sensors and Ion Detection
- X-ray Diffraction in Crystallography
- Carbon and Quantum Dots Applications
- Protein Structure and Dynamics
- Synthesis of Tetrazole Derivatives
- Luminescence and Fluorescent Materials
- Antimicrobial Peptides and Activities
- Advanced biosensing and bioanalysis techniques
- Antimicrobial agents and applications
- Crystallization and Solubility Studies
- Advanced NMR Techniques and Applications
- Essential Oils and Antimicrobial Activity
- Ethnobotanical and Medicinal Plants Studies
- Fluorine in Organic Chemistry
- Electrochemical sensors and biosensors
- Phytochemicals and Antioxidant Activities
- Free Radicals and Antioxidants
- Radiomics and Machine Learning in Medical Imaging
- Phenothiazines and Benzothiazines Synthesis and Activities
- Curcumin's Biomedical Applications
- Supramolecular Chemistry and Complexes
Zhengzhou University
2023-2025
Henan Academy of Sciences
2025
The University of Queensland
2019-2024
Institute of Biophysics
2024
Chinese Academy of Sciences
2024
Northeastern University
2023
National University of Singapore
2023
Tianjin University
2023
Beijing Institute of Fashion Technology
2018-2022
University College Dublin
2015-2018
Abstract Natural antimicrobial peptides (AMPs) and enzymes (AMEs) are promising non-antibiotic candidates against resistance but suffer from low efficiency poor stability. Here, we develop peptide nanozymes which mimic the mode of action AMPs AMEs through de novo design assembly. Through modelling a minimal building block IHIHICI is proposed by combining critical amino acids in hydrophobic isoleucine to conduct Experimental validations reveal that assemble into helical β-sheet nanotubes with...
The mechanism of ethylene polymerization by the widely used Phillips catalyst remains controversial. In this work, we compare initiation, propagation, and termination pathways computationally using small chromasiloxane cluster models for several previously proposed new mechanisms. Where possible, consider complete catalytic cycles predicted kinetics, active site abundances, polymer molecular weights to known properties catalyst. Prohibitively high activation barriers propagation rule out...
The quantitative analysis of trace water in organic solvents has always been a research hotspot, and it is still the development stage needs to be continuously developed. In this study, facile rapid approach was developed for preparation carbon quantum dots (CQDs) with yellow fluorescence emission ultrahigh absolute yields (92.6%). Compared traditional fluorescent molecules, CQDs simpler, faster more environmentally friendly. It found that properties are excellent could quenched by water,...
Abstract Given the challenge of bacterial resistance to antibiotics, there is an urgent need develop alternative antibacterial agents. While some metal sulfides are promising candidates against resistance, their fundamental mechanism action (MoA) remains unclear. Herein, a “coordination‐precipitation” method developed for synthesis sulfide library and evaluation consistency. Employing ethylenediamine as coordination agent thioglycolic acid precipitation agent, 12 different nanocrystals...
A new rhodamine B-based fluorescent probe RL for Cu<sup>2+</sup> has been designed, synthesized, and characterized.
Advanced ScienceVolume 12, Issue 6 2570032 Inside Back CoverOpen Access A Novel "Three-in-One" Copper-Based Metal-Organic Framework Nanozyme Eradicates Colorectal Cancer and Overcomes Chemoresistance for Tumor Therapy (Adv. Sci. 6/2025) Shuohui Dong, DongSearch more papers by this authorHaolin Cao, Haolin CaoSearch authorYe Yuan, Ye YuanSearch authorShuo Liang, Shuo LiangSearch authorZhendong Fu, Zhendong FuSearch authorWei Shi, Wei ShiSearch authorQian Xu, Qian XuSearch authorXiang Zhao,...
Background: Bacterial resistance remains a significant challenge, necessitating the development of new antibacterial strategies. This study introduces rapidly synthesized L-histidine- Fe3O4 (L-His-Fe3O4) nanozyme with enhanced peroxidase (POD)-like activity, designed to improve efficacy and accelerate healing bacteria-infected wounds. Methods: We successfully L-His-Fe3O4 using an ultrafast, room-temperature synthesis method, observed its anti-infection effect explored mechanism through in...
A novel fluorescent sensor for water in organic solvents was proposed based on dynamic quenching of carbon quantum dots.
We report a photoredox platform for constructing styrenyl polyfluoro (hetero)arenes with branch selectivity by taking advantage of sulfinate as both radical-relay precursor and sacrificial nucleofuge. This protocol merges catalysis radical–radical coupling an elimination process in one-pot operation features good functional group tolerance, mild conditions, facile method to access (hetero)aryl derivatives natural products drugs.
A ternary complex among <bold>D2</bold>, DNA and CB[7] can be formed.
Abstract Despite considerable advancements in the treatment of colorectal cancer (CRC), overall survival rate for patients with advanced CRC remains below 50%, primarily due to challenges posed by drug resistance and metastasis. Here, a novel “Three‐in‐One” Cu‐based metal‐organic framework nanozyme peroxidase‐like (POD‐like) activity has been successfully developed, aiming promote cell death dual targeting oxidative stress copper ion homeostasis, which could via apoptosis cuproptosis,...
Human islet amyloid polypeptide (hIAPP), also known as amylin, is a 37-amino-acid peptide, co-secreted with insulin, and widely found in fibril form type-2 diabetes patients. By using all-atom molecular dynamics simulations, we study hIAPP segments (i.e., fibrillar oligomers) formed sequences of naturally occurring variants from cat, rat, pig, presenting different aggregation propensities. We characterize the effect mutations on structural solution-formed models built solid-state NMR data....
In the study, two novel compounds along with new were isolated from Grewia optiva. The have never been reported in any plant source, whereas are for first time studied plant. four characterized as: 5,5,7,7,11,13-hexamethyl-2-(5-methylhexyl)icosahydro-1H-cyclopenta[a]chrysen-9-ol (IX), docosanoic acid (X), methanetriol mano formate (XI) and 2,2’-(1,4-phenylene)bis(3-methylbutanoic (XII). anticholinesterase, antidiabetic, antioxidant potentials of these determined using standard protocols. All...
Herein, based on a coordination-precipitation strategy, we have developed Fe–Mn–S SOD-like nanozyme, which can catalyze the decomposition of ˙O 2 − and exhibited broad-spectrum antibacterial activity against Gram-positive Gram-negative bacterium.