A5000113518- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Fluorine in Organic Chemistry
- Catalytic Cross-Coupling Reactions
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Reactions
- Oxidative Organic Chemistry Reactions
- Chemical Reactions and Isotopes
- Advanced Photocatalysis Techniques
- Asymmetric Hydrogenation and Catalysis
- Advanced Synthetic Organic Chemistry
- Crystallization and Solubility Studies
- Organoboron and organosilicon chemistry
- Advanced Neural Network Applications
- Synthesis of Indole Derivatives
- Synthetic Organic Chemistry Methods
- Computational Drug Discovery Methods
- Chemical Synthesis and Analysis
- CO2 Reduction Techniques and Catalysts
- Mass Spectrometry Techniques and Applications
- Handwritten Text Recognition Techniques
- Spacecraft Design and Technology
- Synthesis of Tetrazole Derivatives
- Click Chemistry and Applications
University of Science and Technology of China
2023-2025
Hefei National Center for Physical Sciences at Nanoscale
2023-2025
Technische Universität Berlin
2022-2024
National University of Singapore
2021-2023
Shenzhen University
2022
University of Science and Technology Beijing
2020
Nanjing University
2015-2019
China University of Geosciences (Beijing)
2009
Abstract The construction of an aryl ketone structural unit by means catalytic carbon–carbon coupling reactions represents the state-of-the-art in organic chemistry. Herein we achieved direct deoxygenative synthesis aqueous solution from readily available aromatic carboxylic acids and alkenes, affording structurally diverse ketones moderate to good yields. Visible-light photoredox catalysis enables deoxygenation as acyl sources with triphenylphosphine a distinct perspective on activation....
We report a general, practical, and scalable means of preparing deuterated aldehydes from aromatic aliphatic carboxylic acids with D2 O as an inexpensive deuterium source. The use Ph3 P O-atom transfer reagent can facilitate the deoxygenation acids, while Ph2 POEt is better for acids. highly precise complex makes this protocol promising late-stage deoxygenative deuteration natural product derivatives pharmaceutical compounds.
The development of a mild, atom- and step-economical catalytic strategy that effectively generates value-added molecules directly from readily available commodity chemicals is central goal organic synthesis. In this context, the thiol–ene click chemistry for carbon–sulfur (C–S) bond construction has found widespread applications in synthesis pharmaceuticals functional materials. contrast, selective carbonyl thiyl radical addition to carbon–carbon multiple bonds remains underdeveloped....
The novel cascade photoredox/iodide catalytic system enables the alkene to serve as a radical acceptor capable of achieving aminodifluoroalkylation alkenes. Cheap iodide salts play vital role in this reaction, which could tune carbocation reactivity through reversible C–I bond formation for controlling reaction selectivity, and series competitive reactions are completely eliminated presence multiple pathways. present dual protocol affords very convenient method direct synthesis various...
Abstract While aldehydes represent a classic class of electrophilic synthons, the corresponding acyl radicals are inherently nucleophilic, which exhibits umpolung reactivity. Generation typically requires noble metal catalysts or excess oxidants to be added. Herein, we report convenient and green approach access radicals, capitalizing on neutral eosin Y-enabled hydrogen atom transfer (HAT) photocatalysis with aldehydes. The generated underwent SOMOphilic substitutions various functionalized...
Given the widespread significance of vicinal diamine units in organic synthesis, pharmaceuticals and functional materials, as well privileged molecular catalysts, an efficient practical strategy that avoids use stoichiometric strong oxidants is highly desirable. We herein report application ligand-to-metal charge transfer (LMCT) excitation to 1,2-diazidation reactions from alkenes TMSN
A visible light mediated radical–radical coupling reaction towards the construction of valuable nitrogen heterocycles has been developed. Piperidine, pyrrolidine, indole, and azetidine scaffolds were synthesized in good to excellent yields from simple substrates.
A hydroacylation reaction of alkenes has been achieved employing readily available carboxylic acids as the acyl source and hydrosilanes a hydrogen via photoredox catalysis. The combination both single electron transfer atom steps dramatically expanded new applications in organic synthesis. protocol also features extremely mild conditions, broad substrate scope, good functional group tolerance, affording novel convenient approach to alkenes.
An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction an enhanced library unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage a stronger C-O bond formation weaker C-C by 1,5-aryl migration under mild reaction conditions. This new protocol is independent substrate redox-potential, electronic, substituent effects. It affords general promising access to 60...
Geminal and vicinal borosilanes are useful building blocks in synthetic chemistry material science. Hydrosilylation/hydroborylation of unsaturated systems offer expedient access to these motifs. In contrast the well-established transition-metal-catalyzed methods, radical approaches rarely explored. Herein we report synthesis geminal from α-selective hydrosilylation alkenyl boronates via photoinduced hydrogen atom transfer (HAT) catalysis. Mechanistic studies implicate that α-selectivity...
Domino-fluorination–protodefluorination decarboxylative cross-coupling of α-keto acids with styrene has been developed via photoredox catalysis. The critical part this strategy is the formation carbon–fluorine (C–F) bond by capture a carbon-centered radical intermediate, which will overcome side reactions during functionalization process. Experimental studies have provided evidence indicating domino-fluorination–protodefluorination pathway acid initiating cycle. present catalytic protocol...
A highly efficient catalytic dearomatization of indoles <italic>via</italic> visible-light photocatalysis is presented. The common indole tethered alcohol at the N1 or C2 position reacts in a cascade fashion, providing facile access to diverse indolone scaffolds.
A practical photoredox and cobalt co-catalyzed C(sp<sup>2</sup>)–H functionalization/C–O bond formation is achieved with dihydrogen as the only by-product.
A novel visible light photoredox catalysis three-component 1,2-difluoroalkylarylation of styrenes was disclosed, and two new C–C bonds were generated in a single step through regioselective incorporation CF<sub>2</sub> group variety indoles to CC bonds.
In view of the widespread significance amide functional groups in organic synthesis and pharmaceutical studies, an efficient practical synthetic protocol that avoids use stoichiometric activating reagents or metallic reductants is highly desirable. A straight-forward pathway to access amides from abundant chemical feedstock would offer a strategic advantage complex amides. We herein disclose direct reductive amidation reaction using readily available aldehydes nitroarenes enabled by...
The reductive single electron transfer (SET) umpolung amination of aldehyde-derived hydrazones has been developed through visible-light-promoted photoredox catalysis. ideal transformation into the corresponding hydrazonamide selective carbon–hydrogen (C–H) bond functionalization represents one most step- and atom-economical methods. This SET strategy features mild conditions a remarkably broad substrate scope, offering an entirely new class to direct C–H amination.
The direct decarboxylative allylation of <italic>N</italic>-arylglycine derivatives has been accomplished <italic>via</italic> visible-light photoredox catalysis.
Abstract We report a general, practical, and scalable means of preparing deuterated aldehydes from aromatic aliphatic carboxylic acids with D 2 O as an inexpensive deuterium source. The use Ph 3 P O‐atom transfer reagent can facilitate the deoxygenation acids, while POEt is better for acids. highly precise complex makes this protocol promising late‐stage deoxygenative deuteration natural product derivatives pharmaceutical compounds.
Diarylmethanes are significant molecules in organic synthesis and play a vital role pharmaceutical development. In this context, we successfully developed visible-light-driven nickel-catalyzed cross-coupling of readily available benzyltrimethylammonium triflates with aryl bromides, enabling the direct various diarylmethane products without need for metal-reducing agents. Mechanistic studies have revealed that benzyl radicals, generated through photocatalysis, may serve as key intermediates,...
An efficient deoxygenative radical cyclization reaction has been reported for the synthesis of fluorenones by employing various biarylcarboxylic acids via photoredox catalysis. Attractive features this process include generation acyl radical, which quickly underdone intramolecular cyclization. This method marks first photocatalytic coupling constructing carbon-carbon bond, further synthesizes valuable fluorenone products with mild conditions, good yields, and functional-group compatibility.
The direct reduction of carboxylic acids to aldehydes with hydrosilane was achieved through visible light photoredox catalysis. combination both single electron transfer and hydrogen atom steps offers a novel convenient approach selective aldehydes. method also features mild conditions, high yields, broad substrate scope, good functional group tolerance, such as alkyne, ester, ketone, amide amine groups.