A5043711843- Neuroinflammation and Neurodegeneration Mechanisms
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- Animal Virus Infections Studies
- Primate Behavior and Ecology
- Multiple Sclerosis Research Studies
- Long-Term Effects of COVID-19
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Polyomavirus and related diseases
- Herpesvirus Infections and Treatments
- Antifungal resistance and susceptibility
- Blood Coagulation and Thrombosis Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cell Adhesion Molecules Research
- Protein Degradation and Inhibitors
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Antenna Design and Analysis
- Coenzyme Q10 studies and effects
- Toxoplasma gondii Research Studies
- Microbial Natural Products and Biosynthesis
- Antimicrobial Peptides and Activities
- Nuclear Receptors and Signaling
- Vitamin K Research Studies
Novartis Institutes for BioMedical Research
2009-2024
Novartis (Switzerland)
2000-2024
University Hospital Heidelberg
2003-2005
Heidelberg University
1995-2005
University Medical Centre Mannheim
2000-2005
École Polytechnique Fédérale de Lausanne
2002
University of Würzburg
1994-1995
We identified the thiomuracins, a novel family of thiopeptides produced by rare-actinomycete bacterium typed as Nonomuraea species, via screen for inhibition growth bacterial pathogen Staphylococcus aureus. Thiopeptides are class macrocyclic, highly modified peptides that decorated thiazoles and defined central six-membered heterocyclic ring system. Mining genomes thiopeptide-producing strains revealed elusive biosynthetic route this antibiotics. The chromosomally encoded, ribosomally...
Visceral leishmaniasis is responsible for up to 30,000 deaths every year. Current treatments have shortcomings that include toxicity and variable efficacy across endemic regions. Previously, we reported the discovery of GNF6702, a selective inhibitor kinetoplastid proteasome, which cleared parasites in murine models leishmaniasis, Chagas disease, human African trypanosomiasis. Here, describe characterization LXE408, structurally related kinetoplastid-selective proteasome currently Phase 1...
Reactivation of BK polyomavirus (BKPyV) can cause significant kidney and bladder disease in immunocompromised patients. There are currently no effective, BKPyV-specific therapies. MAU868 is a novel, human immunoglobulin (Ig) G1 monoclonal antibody that binds the major capsid protein, VP1, BKPyV with picomolar affinity, neutralizes infection by 4 genotypes (EC
Abstract Severe traumatic brain injury stimulates the release of soluble intercellular adhesion molecule‐1 (sICAM‐1) into CSF. Studies in cultured mouse astrocytes suggest that sICAM‐1 induces production macrophage inflammatory protein‐2 (MIP‐2). In present study, we investigated underlying mechanisms for MIP‐2 induction. induced lacking membrane‐bound ICAM‐1, indicating its action is due to heterophilic binding an undescribed receptor rather than homophilic surface ICAM‐1. Signal...
The serine protease factor XI (FXI) is a prominent drug target as it holds promise to deliver efficacious anticoagulation without an enhanced risk of major bleeds. Several efforts have been described targeting the active form enzyme, FXIa. Herein, we disclose our identify potent, selective, and orally bioavailable inhibitors Compound 1, identified from diverse library internal inhibitors, was originally designed complement D inhibitor exhibited submicromolar FXIa activity encouraging...
ABSTRACT Intravenous infection of cats with feline immunodeficiency virus was used as a model system to study activation replication in brain-resident microglial cells vitro. Virus release by ramified isolated from subclinically infected animals detectable cell-free tissue culture supernatant only reverse transcription and nested PCR gag -specific RNA sequences not virion-associated transcriptase activity. In contrast, cocultivation vivo-infected mitogen-activated peripheral blood...
The neurotropic strain of the mouse hepatitis virus (MHV), MHV-IV or JHM virus, causes neurological disorders in rats and mice when given intracerebrally 1,2. Depending on rat age infected animal different courses disease have been observed. Up to 2 weeks post partum Lewis (LEW) develop an acute fatal encephalitis, whereas animals older than 3 usually do not succumb infection but suffer from a subacute paralytic accompanied by multiple disorders. However, majority them recovers completely...