A5078249208- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Analytical Methods in Pharmaceuticals
- Mass Spectrometry Techniques and Applications
- Antibiotics Pharmacokinetics and Efficacy
- Pesticide Residue Analysis and Safety
- Protein purification and stability
- Pharmacological Effects and Assays
- Chromatography in Natural Products
- Analytical chemistry methods development
- Analytical Chemistry and Sensors
- Advanced biosensing and bioanalysis techniques
- Metabolomics and Mass Spectrometry Studies
- Advanced Chemical Sensor Technologies
- Biosimilars and Bioanalytical Methods
- Monoclonal and Polyclonal Antibodies Research
- Spectroscopy and Chemometric Analyses
- Crystallization and Solubility Studies
- Lipid Membrane Structure and Behavior
- Amino Acid Enzymes and Metabolism
- Drug Solubulity and Delivery Systems
- Electrochemical sensors and biosensors
- NMR spectroscopy and applications
- Pharmacological Effects and Toxicity Studies
University of Liège
2015-2024
Jinan University
2015-2024
Centre Hospitalier Universitaire de Liège
2009
KU Leuven
1993
Ghent University
1992
Uppsala University
1977
Human monoamine oxidase B (hMAO-B) has emerged as a pivotal therapeutic target for Parkinson's disease. Due to adverse effects and shortage of commercial drugs, there is need novel, highly selective, reversible hMAO-B inhibitors with good blood-brain barrier permeability. In this study, high-throughput at-line nanofractionation screening platform was established extracts from Chuanxiong Rhizoma, which resulted in the discovery 75 active compounds, including phenolic acids, volatile oils,...
Abstract The enantiomers of a series basic drugs were separated in capillary zone electrophoresis (CZE) phosphate buffers, pH 3, containing β‐cyclodextrin or one its derivatives as chiral selectors and uncoated fused silica capillaries thermostated at 15°C. nature the cationic component background electrolyte was found to have significant influence on achiral resolution peak symmetry. best results obtained with triethanolamine, which then used adjust buffer all further experiments. effects...
General strategies for the development of capillary electrophoretic methods enantiomeric separation basic, acidic or neutral drugs were developed. For all kinds compounds, use a buffer made 100 mM phosphoric acid adjusted to pH 3 with triethanolamine and containing anionic and/or uncharged cyclodextrin (CD) derivatives as chiral selectors was recommended. Two different optimization schemes depending on basic character analytes, elaborated. most compounds present in cationic form at 3, could...
In this study an attempt has been made to explain the reasons for changing enantioseparation selectivity in some dual cyclodextrin (CD) systems compared use of single chiral selectors capillary electrophoresis (CE). An explanation changes is proposed based on effect selector mobility analyte. order support mechanism, several were designed basis known recognition pattern enantiomers individual CDs. most cases separation could be adjusted a way. There was no experimental evidence simultaneous...
Separations using CE employing non-aqueous BGE are already as well established separations in aqueous buffers. The separation mechanisms achiral with BGEs most likely similar to those However, for the of enantiomers involving their interaction chiral buffer additives, might be very different and BGEs. While hypothesis regarding distinct enantiomer has been mentioned several papers, no direct proof this reported date. In present study, propranolol were resolved methanolic two single isomer...
In the present study migration order of propranolol enantiomers with various native CDs and neutral charged CD derivatives was examined in capillary electrophoresis (CE). The reversal enantiomer observed due to sulfation beta-CD on its primary hydroxy groups. structures intermolecular selector-select temporary diastereomeric associates solution were elucidated based 1D rotating frame nuclear Overhauser effect spectroscopy (1D ROESY) experiments. Major structural differences between complexes...