A5084708096- RNA Interference and Gene Delivery
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Phase Equilibria and Thermodynamics
- Analytical Chemistry and Chromatography
- Advanced biosensing and bioanalysis techniques
- Analytical Methods in Pharmaceuticals
- Crystallization and Solubility Studies
- Inhalation and Respiratory Drug Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Protein purification and stability
- Protein Interaction Studies and Fluorescence Analysis
- Spectroscopy and Chemometric Analyses
- Polymer Foaming and Composites
- Cervical Cancer and HPV Research
- Cancer Treatment and Pharmacology
- Graphene and Nanomaterials Applications
- Flavonoids in Medical Research
- Surfactants and Colloidal Systems
University of Liège
2015-2024
Gembloux Agro-Bio Tech
2017
In recent year, cationic liposomes have gained a lot of attention for siRNA delivery. Despite this, intracellular barriers as endosomal escape and cytosolic delivery still represent challeng, well the cytotoxicity due to lipids. To address these issues, we developed four liposomal formulations, composed two different lipids (DOTAP DC-Cholesterol) ratio co-lipids (cholesterol DOPE). The objective is dissect impacts on efficacy cytotoxicity. Liposomes were complexed at six N/P molar ratios,...
Polyethylene glycol (PEG) is used in Lipid Nanoparticles (LNPs) formulations to confer stealth properties and traditionally anchored membranes by a lipid moiety whose length significantly impacts the LNPs fate vivo. C18 acyl chains are efficiently membrane, while shorter C14 lipids quickly desorbed replaced protein corona responsible for completely different of LNPs. In this context, method predict biological behavior depending on lipid-PEG dissociation was developed using Nanoparticle...