A5072590647- Natural product bioactivities and synthesis
- Coronary Interventions and Diagnostics
- Bioinformatics and Genomic Networks
- Cancer Genomics and Diagnostics
- Lipoproteins and Cardiovascular Health
- Gene expression and cancer classification
- Acute Kidney Injury Research
- Genomics, phytochemicals, and oxidative stress
- Cardiac Ischemia and Reperfusion
- Acute Myocardial Infarction Research
- Liver Disease and Transplantation
- Pharmacological Effects of Natural Compounds
- Atherosclerosis and Cardiovascular Diseases
- AI in cancer detection
- Pharmacology and Obesity Treatment
- Epigenetics and DNA Methylation
- Natural Antidiabetic Agents Studies
- Cardiovascular and Diving-Related Complications
- Autophagy in Disease and Therapy
- Biochemical Acid Research Studies
- Phytochemistry and Biological Activities
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Phytochemicals and Antioxidant Activities
- Machine Learning in Healthcare
Second Affiliated Hospital of Dalian Medical University
2019-2024
Dalian Medical University
2019-2024
Abstract Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid, OA) is a kind of pentacyclic triterpene, which widely distributes in nature. OA possesses powerful anti-cancer effect; however, its low solubility limits bioavailability and application. In this study, new derivative, K73-03, was used to determine effect on liver cancer cells detailed molecular mechanisms. Here, we show that K73-03 may lead the disorder mitochondria HepG2 cells, leading excessive ROS production apoptosis cells....
Rapid progression of non-target lesions (NTLs) leads to a high incidence NTL related cardiac events post-PCI, which accounting half the recurrent events. It is important identify risk factors and establish an accurate clinical prediction model for rapid NTLs post-PCI. PCSK9 inhibitors lower LDL-c levels significantly, also show anti-inflammation effect, may have potential reduce We tried test this hypothesis explore mechanisms.
Abstract The endothelial dysfunction induced by oxidized low‐density lipoprotein (ox‐LDL) plays an important role in the pathogenesis of atherosclerosis, which can lead to oxidative stress and inflammation. autophagy process atherosclerosis has drawn increasing attention. human umbilical vein cells (HUVECs), whose Ras‐related C3 botulinum toxin substrate 1 (Rac1) Rac3 was knockdown, were used detect whether possible molecular mechanisms Rac1 for anti‐inflammatory effected downregulation...
Although computational methods for driver gene identification have progressed rapidly, it is far from the goal of obtaining widely recognized genes all cancer types. The lists predicted by these often lack consistency and stability across different studies or datasets. In addition to analytical performance, some tools may require further improvement regarding operability system compatibility. Here, we developed a user-friendly R package (DriverGenePathway) integrating MutSigCV statistical...
1) To investigate the expression of platelet collagen receptor glycoprotein VI (GPVI) on surface platelets in patients with coronary heart disease (CHD). 2) intercellular adhesion molecule-1 (ICAM-1) and vascular cell (VCAM-1) endothelial cells after exposure to subjects' platelets.Platelets were extracted from blood samples 97 subjects including 43 acute syndrome (ACS), 21 stable angina pectoris (SAP), 33 serving as controls which CHD was excluded. Using flow cytometry, we measured GPVI...
Abstract Background Cancer, a disease with high morbidity and mortality rates, poses significant threat to human health. Driver genes, which harbor mutations accountable for the initiation progression of tumors, play crucial role in cancer development. Identifying driver genes stands as paramount objective research precision medicine. Results In present work, we propose method identifying using Generalized Linear Regression Model (GLM) Shrinkage double-Weighted strategies based on Functional...
(1) Background: In-stent Restenosis (ISR) is a major factor influencing the prognosis and revascularization of target lesions. The plaque composition unclear; therefore, it critical to investigate ISR identify clinical intervention markers. (2) Methods: This study was conducted on 36 patients with drug-eluting stent restenosis. were classified into Low Neutrophil–Lymphocyte Ratio (L-NLR) High (H-NLR) according median NLR level patients. Discrepancies in current information such as baseline...
<title>Abstract</title> Background Rapid progression of non-target lesions (NTLs) leads to a high incidence NTL related cardiac events post-PCI, which accounting half the recurrent events. It is important identify risk factors for rapid NTLs post-PCI. Proprotein convertase subtilisin-kexin 9(PCSK9) inhibitors lower low-density lipoprotein cholesterol(LDL-c) levels significantly, also show anti-inflammation effect, and may have potential reduce Methods This retrospective study included 1250...
Pyruvate dehydrogenase complex (PDH) is an important of three enzymes that transforms pyruvate into acetyl-CoA, subsequently entering the tricarboxylic acid (TCA) cycle to produce ATP and electron donors. As a key regulator energy metabolic homeostasis, PDH considered potential therapeutic target many diseases. On other hand, relationship between obesity not clear. In this study, peripheral blood Pdha1fl/flLyz2-Cre C57BL/6 mice fed high-fat diet (HFD) was collected subjected extensive...
Abstract Background The detachment of the left atrial appendage(LAA) thrombus is major cause cardioembolic stroke(CES)/cardioembolic transient ischemic attack(CETIA). A LAA very infrequently detected in presence sinus rhythm. Patent foramen ovale(PFO) another common reason for CES/CETIA, especially among young and middle-aged people. Case Presentation We reported a case 46-year-old man who presented with TIAs was subsequently found PFO despite being rhythm basically normal structure...
Abstract Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid, OA) is a kind of pentacyclic triterpene, which widely distributes in nature. OA possesses powerful anti-cancer effect; however, its low solubility limits bioavailability and application. In this study, new derivative, K73-03, was used to determine effect on liver cancer cells detailed molecular mechanisms. We found that K73-03 could significantly inhibit the cell viability, migration colony formation SMMC-7721 HepG2 dose-dependent...
Abstract Phosphocreatine (PCr) has been shown to have a cardio-protective effect during cardiopulmonary resuscitation (CPR). However, little is known about its impact on atherosclerosis. In this study, we firstly evaluated the pharmacological effects of PCr antioxidative defenses and mitochondrial protection against hydrogen peroxide (H 2 O ) induced human umbilical vascular endothelial cells (HUVECs) damage. Then investigated hypolipidemic hyperlipidemic rat model. Via in vitro studies, H...
Drug sensitivity prediction plays a crucial role in precision cancer therapy. Collaboration among medical institutions can lead to better performance drug prediction. However, patient privacy and data protection regulation remain severe impediment centralized studies. For the first time, we proposed federated model with high generalization, combining distributed sources while protecting private data. Cell lines are classified into three categories using waterfall method. Focal loss for...
Acute Coronary Syndrome (ACS) is a critical cardiovascular condition often accompanied by comorbidities that can significantly impact disease progression and management. The identification of biomarkers associated with these plays crucial role in ensuring effective patient care. In this study, our objective was to utilize the LassoNet feature selection technique, which combines LASSO neural networks, identify ACS comorbidities. dataset we analyzed comprised patients such as hypertension,...